WormBase Tree Display for Gene: WBGene00022727

WBGene00022727 SMap: S_parent: Sequence: ZK381
  Identity: Version: 3
    Name: CGC_name: prkl-1 Person_evidence: WBPerson114
      Sequence_name: ZK381.5
      Molecular_name: ZK381.5a
        ZK381.5a.1
        CE41743
        ZK381.5b
        CE41744
        ZK381.5b.1
      Other_name (2)
      Public_name: prkl-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:06 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 15 Mar 2007 17:00:31 WBPerson2970 Name_change: CGC_name: prkl-1
        3 02 Aug 2016 10:45:57 WBPerson2970 Name_change: Other_name: nde-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: prkl
    Allele: WBVar00601042 Inferred_automatically: From strain object: OU100
      WBVar02146578
      WBVar00027131
      WBVar00918811
      WBVar00918812
      WBVar00918813
      WBVar00918814
      WBVar00918815
      WBVar00190365
      WBVar00918816
      WBVar00918817
      WBVar00190367
      WBVar00190368
      WBVar00918818
      WBVar00297449
      WBVar00918819
      WBVar00190369
      WBVar00918820
      WBVar00918821
      WBVar00918822
      WBVar00918823
      WBVar00918824
      WBVar00918825
      WBVar00918826
      WBVar01516349
      WBVar00918827
      WBVar01516350
      WBVar00252121
      WBVar00918828
      WBVar01516351
      WBVar00918829
      WBVar01516352
      WBVar01516353
      WBVar00918830
      WBVar00918831
      WBVar00918832
      WBVar00918833
      WBVar00918834
      WBVar00094255
      WBVar00918835
      WBVar02134103
      WBVar00918836
      WBVar00918837
      WBVar00918838
      WBVar00918839
      WBVar00918840
      WBVar00918841
      WBVar00918842
      WBVar00918843
      WBVar00918844
      WBVar00918845
      WBVar00918846
      WBVar00918847
      WBVar00918848
      WBVar00918849
      WBVar00918850
      WBVar00918851
      WBVar02020849
      WBVar00918852
      WBVar01818832
      WBVar00918853
      WBVar00918854
      WBVar00918855
      WBVar00918856
      WBVar00918857
      WBVar00918858
      WBVar00918859
      WBVar00918860
      WBVar00918861
      WBVar00918862
      WBVar01499395
      WBVar01499396
      WBVar00254781
      WBVar01794760
      WBVar00427854
      WBVar00427855
      WBVar00427856
      WBVar01499633
      WBVar00427857
      WBVar00427858
      WBVar00427859
      WBVar00427860
      WBVar00427861
      WBVar00427862
      WBVar00427863
      WBVar00427864
      WBVar00427865
      WBVar02146579
      WBVar02146580
      WBVar01966498
      WBVar01966499
      WBVar02148021
      WBVar00302047
      WBVar00260553
      WBVar01923737
      WBVar01923738
      WBVar01500245
      WBVar01581551
      WBVar00027126
      WBVar01581552
    Strain: WBStrain00030530
      WBStrain00033022
    RNASeq_FPKM (74)
    GO_annotation: 00005326
      00126723
    Ortholog (47)
    Paralog: WBGene00004112 Caenorhabditis elegans From_analysis: Panther
      WBGene00015217 Caenorhabditis elegans From_analysis: TreeFam
            Panther
    Structured_description: Concise_description: prkl-1 encodes a homolog of Drosophila ESPINAS and PRICKLE, and of humanPRICKLE1, PRICKLE2, and LMO6; prkl-1 enables Wnt-directed planar cellpolarity; prkl-1 is required for the fully asymmetrical division of B.aversus B.p cells, though this requirement is quantitatively weak. Paper_evidence: WBPaper00027345
          Curator_confirmed: WBPerson567
          Date_last_updated: 25 Oct 2006 00:00:00
      Automated_description: Predicted to enable zinc ion binding activity. Expressed in several structures, including QL; egg-laying apparatus; gonad; head; and somatic nervous system. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Is an ortholog of human PRICKLE2 (prickle planar cell polarity protein 2) and PRICKLE3 (prickle planar cell polarity protein 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111448 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17019)
  Molecular_info: Corresponding_CDS: ZK381.5a
      ZK381.5b
    Corresponding_CDS_history: ZK381.5:wp83
      ZK381.5a:wp183
      ZK381.5b:wp183
    Corresponding_transcript: ZK381.5a.1
      ZK381.5b.1
    Other_sequence: BMC13568_1
      JI171960.1
      BM01268
    Associated_feature (14)
    Transcription_factor: WBTranscriptionFactor000259
  Experimental_info: RNAi_result (21)
    Expr_pattern (11)
    Drives_construct: WBCnstr00002499
      WBCnstr00002500
      WBCnstr00009089
      WBCnstr00009093
      WBCnstr00014217
      WBCnstr00024021
    Construct_product: WBCnstr00009089
      WBCnstr00009097
      WBCnstr00009098
      WBCnstr00009099
      WBCnstr00023141
      WBCnstr00024021
    Microarray_results (30)
    Expression_cluster: WBPaper00029359_1124
      WBPaper00029359_1141
      WBPaper00029359_1280
      WBPaper00029359_1304
      WBPaper00029359_1351
      WBPaper00029359_1444
      WBPaper00029359_1497
      WBPaper00029359_1504
      WBPaper00029359_1525
      WBPaper00029359_1604
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035197:fer-1_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00041222:unc-120(st364)_downregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045257:bar-1(ga80)_downregulated
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050743:elli-1(sam-3)_upregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055013:hmg-4(RNAi)_downregulated
      WBPaper00055013:spt-16(RNAi)_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055648:male-vas-deferens_expressed
      WBPaper00056039:ptl-1(ok621)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:ALM_BDU
      WBPaper00061340:DA
      WBPaper00061340:DB
      WBPaper00061340:DD
      WBPaper00061340:Glia
      WBPaper00061340:I5
      WBPaper00061340:mc2
      WBPaper00061340:mc3
      WBPaper00061340:mu_int_mu_anal
      WBPaper00061340:mu_sph
      WBPaper00061340:Z1_Z4
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061479:hda-1(ne4748)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:cfz-2_18944-cfz-2_2268
      WBPaper00061527:dsh-1_3575-C40A11.4
      WBPaper00061651:VC_4_5_enriched
      WBPaper00061902:camt-1(ok515)_regulated_AFD
      WBPaper00062095:unc-4(e120)_upregulated_VA-neuron
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_downregulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00062672:dcp-66(RNAi)_upregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065029:cadmium_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065331:100nM-ivermectin_downregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:6_3
      WBPaper00065841:37_0
      WBPaper00065841:68_0
      WBPaper00065841:98_0
      WBPaper00065841:102_0
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_6_4
      cgc4489_group_18
      cgc4489_group_19
      cgc4489_group_23
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_N2
      WBPaper00027111:rrf-3(pk1426)_downregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035227:heat_shock_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041939:control_vs_UVC-exposed_3h
      WBPaper00045673:colistin_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (78)
  Map_info: Map: IV Position: 3.27518 Error: 0.000766
    Positive: Positive_clone: ZK381 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (18)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene