WBGene00006369 | SMap | S_parent | Sequence | R03E1 |
| Identity | Version | 1 |
| | Name | CGC_name | sym-4 | Person_evidence | WBPerson252 |
| | | Sequence_name | R03E1.1 |
| | | Molecular_name | R03E1.1 |
| | | | R03E1.1.1 |
| | | | CE18901 |
| | | Other_name | CELE_R03E1.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | sym-4 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | sym |
| | Allele | WBVar00089187 |
| | | WBVar01206498 |
| | | WBVar01206499 |
| | | WBVar01206500 |
| | | WBVar01499887 |
| | | WBVar01206501 |
| | | WBVar01499519 |
| | | WBVar01206502 |
| | | WBVar01499888 |
| | | WBVar01206503 |
| | | WBVar01206504 |
| | | WBVar01206505 |
| | | WBVar00523612 |
| | | WBVar01206506 |
| | | WBVar00523613 |
| | | WBVar01206507 |
| | | WBVar01499710 |
| | | WBVar01206508 |
| | | WBVar00523614 |
| | | WBVar01206509 |
| | | WBVar00523615 |
| | | WBVar00523616 |
| | | WBVar01206510 |
| | | WBVar01206511 |
| | | WBVar00523617 |
| | | WBVar01206512 |
| | | WBVar00523618 |
| | | WBVar01206513 |
| | | WBVar00523619 |
| | | WBVar01206514 |
| | | WBVar00523620 |
| | | WBVar00523621 |
| | | WBVar01206515 |
| | | WBVar01206516 |
| | | WBVar00523622 |
| | | WBVar00523623 |
| | | WBVar01206517 |
| | | WBVar01206518 |
| | | WBVar00523624 |
| | | WBVar00523625 |
| | | WBVar01206519 |
| | | WBVar02027629 |
| | | WBVar00523626 |
| | | WBVar00523627 |
| | | WBVar00523628 |
| | | WBVar00300597 |
| | | WBVar00302514 |
| | | WBVar00101795 |
| | | WBVar00084631 |
| | | WBVar00084632 |
| | | WBVar00084633 |
| | | WBVar00084634 |
| | | WBVar00084635 |
| | | WBVar00084636 |
| | | WBVar00084637 |
| | | WBVar00084638 |
| | | WBVar00084639 |
| | | WBVar00084640 |
| | | WBVar00084641 |
| | | WBVar00084642 |
| | | WBVar01941935 |
| | | WBVar01941936 |
| | | WBVar01941937 |
| | | WBVar01679397 |
| | | WBVar01679398 |
| | | WBVar01760155 |
| | | WBVar01679399 |
| | | WBVar01499041 |
| | | WBVar01946292 |
| | | WBVar01946293 |
| | | WBVar01946294 |
| | | WBVar00217993 |
| | | WBVar01946295 |
| | | WBVar00217996 |
| | | WBVar01787894 |
| | | WBVar00237348 |
| | | WBVar01552674 |
| | | WBVar01552675 |
| | | WBVar00299238 |
| | | WBVar01472372 |
| | | WBVar01472373 |
| | | WBVar01472375 |
| | | WBVar01472376 |
| | | WBVar02125208 |
| | | WBVar01572837 |
| | | WBVar01704012 |
| | | WBVar01572838 |
| | | WBVar01704013 |
| | | WBVar01622089 |
| | | WBVar01622090 |
| | | WBVar01488073 |
| | | WBVar00089186 |
| | | WBVar01497277 |
| | | WBVar01206482 |
| | | WBVar00310474 |
| | | WBVar01206483 |
| | | WBVar01206484 |
| | | WBVar01206485 |
| | | WBVar01955196 |
| | | WBVar01206486 |
| | | WBVar01955197 |
| | | WBVar01206487 |
| | | WBVar02122980 |
| | | WBVar01206488 |
| | | WBVar02122981 |
| | | WBVar01206489 |
| | | WBVar01206490 |
| | | WBVar01206491 |
| | | WBVar01206492 |
| | | WBVar01206493 |
| | | WBVar01206494 |
| | | WBVar01498960 |
| | | WBVar01206495 |
| | | WBVar01206496 |
| | | WBVar01500067 |
| | | WBVar01206497 |
| | Legacy_information | [Herman RK] sym-4(mn619) or sym-4(mn620) by itself is essentially wild type but is synthetic lethal with any mec-8 loss-of-function mutation |
| | Strain | WBStrain00003499 |
| | | WBStrain00034406 |
| | RNASeq_FPKM (74) |
| | Contained_in_operon | CEOPX128 |
| | Ortholog (37) |
| | Structured_description | Concise_description | sym-4 encodes a large (1,043-residue) protein that is required for viability in a mec-8 mutant background, and is also required by itself for normally rapid growth and locomotion; SYM-4 is orthologous to human WDR44, and has a nondescript N-terminal domain, with a C-terminal domain containing seven WD repeats; SYM-4 is broadly expressed, in larval and adult pharynx, digestive tract, neurons, vulva, body wall muscle, and coelomocytes; sym-4 is synthetically lethal with mec-8, with double mutants showing an abnormally buccal cavity between the anterior end of the embryo and the internal anterior end of the pharyngeal primordium; mec-8;sym-4 embryos arrest development at hatching, are unable to eat, and thus die; SYM-4 may function in concert with SYM-3, since sym-3 mutants have the same synthetic lethal phenotype as sym-4. | Paper_evidence | WBPaper00003663 |
| | | | | | WBPaper00006395 |
| | | | | | WBPaper00006525 |
| | | | | | WBPaper00024639 |
| | | | | | WBPaper00031006 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 03 Jan 2008 00:00:00 |
| | | Automated_description | Enriched in several structures, including ABalapapap; ABalapppap; excretory cell; head mesodermal cell; and neurons based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-12; hsf-1; and sir-2.1 based on microarray; tiling array; and RNA-seq studies. Is affected by four chemicals including rotenone; stavudine; and fluvastatin based on RNA-seq and microarray studies. Human WDR44 enables molecular sequestering activity and small GTPase binding activity. Is predicted to encode a protein with the following domains: WD repeat-containing protein WDR44/Dgr2; WD domain, G-beta repeat; WD40-repeat-containing domain superfamily; WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; and Phosphorylation site. Is an ortholog of human WDR44 (WD repeat domain 44). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | R03E1.1 |
| | Corresponding_transcript | R03E1.1.1 |
| | Other_sequence (31) |
| | Associated_feature | WBsf654560 |
| | | WBsf671239 |
| | | WBsf982278 |
| | | WBsf1007841 |
| | | WBsf1007842 |
| | | WBsf238203 |
| | | WBsf238204 |
| Experimental_info | RNAi_result | WBRNAi00062558 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00000324 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00017353 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00026014 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00034557 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00051178 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027424 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00062557 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Chronogram453 |
| | | Expr6450 |
| | | Expr1025719 |
| | | Expr1032568 |
| | | Expr1154885 |
| | | Expr2017182 |
| | | Expr2035318 |
| | Drives_construct | WBCnstr00003957 |
| | | WBCnstr00034385 |
| | Construct_product | WBCnstr00034385 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:excretory-cell_larva_enriched |
| | | WBPaper00037950:excretory-cell_larva_SelectivelyEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051265:F1_morc-1(tm6048)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_upregulated_ClassI |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059604:fluvastatin_downregulated_dlk-1(km12) |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:OLQ_grandparent |
| | | WBPaper00061527:nrde-3-tra-4_10484 |
| | | WBPaper00061527:utx-1_2886-swan-1_2192 |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_PGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | cgc4489_group_3 |
| | | WBPaper00025032:cluster_13 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00040985:AIN-2_L4_intestine |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (27) |
| Map_info | Map | X | Position | 16.6582 | Error | 0.012267 |
| | Positive | Inside_rearr | mnDp1 |
| | | Positive_clone | R03E1 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | mnDf19 |
| | Mapping_data | 2_point | 7094 |
| | | | 7095 |
| | | Multi_point | 4152 |
| | | Pos_neg_data | 10233 |
| | | | 10234 |
| Reference (14) |
| Method | Gene |