WormBase Tree Display for Gene: WBGene00002066

WBGene00002066 Evidence: Person_evidence: WBPerson1666
  SMap: S_parent: Sequence: M110
  Identity: Version: 1
    Name: CGC_name: ifg-1 Person_evidence: WBPerson1666
      Sequence_name: M110.4
      Molecular_name (15)
      Other_name: CELE_M110.4 Accession_evidence: NDB BX284602
      Public_name: ifg-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ifg
    Allele: WBVar00092465
      WBVar01499702
      WBVar01626915
      WBVar00226145
      WBVar01498435
      WBVar01695769
      WBVar01695770
      WBVar01695771
      WBVar00748865
      WBVar00748866
      WBVar00748867
      WBVar00748868
      WBVar00748869
      WBVar00748870
      WBVar00748871
      WBVar00748872
      WBVar00748873
      WBVar00748874
      WBVar01438730
      WBVar01949201
      WBVar00748875
      WBVar01438731
      WBVar00748876
      WBVar01438733
      WBVar00748877
      WBVar01438734
      WBVar00748878
      WBVar00748879
      WBVar00748880
      WBVar00748881
      WBVar00748882
      WBVar00748883
      WBVar00748884
      WBVar00748885
      WBVar00748886
      WBVar00748887
      WBVar00748888
      WBVar00748889
      WBVar00748890
      WBVar00748891
      WBVar00748892
      WBVar00748893
      WBVar00748894
      WBVar00748895
      WBVar00748896
      WBVar00748897
      WBVar00748898
      WBVar00748899
      WBVar00748900
      WBVar00748901
      WBVar00748902
      WBVar00748903
      WBVar00748904
      WBVar00748905
      WBVar00748906
      WBVar00748907
      WBVar00104630
      WBVar01242104
      WBVar00070909
      WBVar01242107
      WBVar00371735
      WBVar00371736
      WBVar00371737
      WBVar00371738
      WBVar00371739
      WBVar00371740
      WBVar00371741
      WBVar00371742
      WBVar00371743
      WBVar00371744
      WBVar00371745
      WBVar00371746
      WBVar02069267
      WBVar01498940
      WBVar02151769
      WBVar00551727
    Strain: WBStrain00001270
      WBStrain00024079
      WBStrain00036060
      WBStrain00024080
    RNASeq_FPKM (74)
    GO_annotation: 00003642
      00003643
      00003644
      00003645
      00003646
      00006169
      00006170
      00109964
      00109965
    Ortholog (59)
    Structured_description: Concise_description: ifg-1 encodes, by alternative splicing, two orthologs of the translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G); by homology, IFG-1 is predicted to function in poly(A) tail-dependent translation initiation; loss of ifg-1 activity in adult animals extends lifespan. Paper_evidence: WBPaper00005068
            WBPaper00012788
            WBPaper00012830
            WBPaper00012882
            WBPaper00012897
            WBPaper00013003
            WBPaper00029008
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 25 Jul 2007 00:00:00
      Automated_description: Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Located in cytosol. Part of eukaryotic translation initiation factor 4F complex. Expressed in several structures, including gonad. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Is an ortholog of human EIF4G3 (eukaryotic translation initiation factor 4 gamma 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060892 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3296)
  Molecular_info: Corresponding_CDS: M110.4a
      M110.4b
      M110.4c
      M110.4d
      M110.4e
    Corresponding_CDS_history: M110.4d:wp270
      M110.4e:wp261
    Corresponding_transcript: M110.4a.1
      M110.4b.1
      M110.4c.1
      M110.4d.1
      M110.4e.1
    Other_sequence: CGC01168_1
      CBC07565_1
    Associated_feature (24)
  Experimental_info: RNAi_result (88)
    Expr_pattern: Chronogram1630
      Expr2003
      Expr4023
      Expr1021338
      Expr1031219
      Expr1154648
      Expr2012694
      Expr2030930
    Drives_construct: WBCnstr00002165
      WBCnstr00036481
    Construct_product: WBCnstr00036481
    Regulate_expr_cluster: WBPaper00039835:ifg-1_downregulated
      WBPaper00039835:ifg-1_upregulated
      WBPaper00050015:ifg-1(RNAi)_downregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
    Antibody: WBAntibody00001408
      WBAntibody00001409
      WBAntibody00001410
      WBAntibody00001654
    Microarray_results (36)
    Expression_cluster: WBPaper00028451:Oogenic_protein
      WBPaper00029359_1280
      WBPaper00029359_1310
      WBPaper00029359_1364
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1578
      WBPaper00029359_1604
      WBPaper00032425:up_in_rde-4
      WBPaper00032425:up_in_zfp-1
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00035073:mitochondria_protein
      WBPaper00036291:ung-1_regulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044616:alg-3-4_downregulated_gene
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049736:15deg-then-25deg(12hr)_downregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050015:ifg-1(RNAi)_downregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050514:CEBP-1_interacting
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051310:LIN-41_interacting
      WBPaper00051555:atm-1(gk186)_regulated_protein
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055013:HMG-3_interacting_protein
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055648:germline_expressed
      WBPaper00055969:electromagnetic-field_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00059174:MEG-3_interacting
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00060908:TEBP-2_interacting
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061466:nath-10(icb99)_downregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:mtr-4_1623-W03F9.10_103
      WBPaper00061527:utx-1_2886-swan-1_2192
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062123:GLH-1_interacting
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_upregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00064315:mes-3(bn199)_downregulated_EGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F2
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066085:hda-3(ok1991)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_8
      WBPaper00025032:cluster_48
      WBPaper00025032:cluster_70
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00027758:Group_IV
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00036286:Pattern_G
      WBPaper00037695:LD_DD_6-day
      WBPaper00037695:WC_5-day
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
      WBPaper00040821:Au-NP_regulated
      WBPaper00040823:alg-1(gk214)_downregulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00040876:mir-35_upregulated
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042548:miRISC_enriched
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047070:DAF-16-dependent_UV_response
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_7
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(83_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SET
      [cgc5767]:expression_class_SE_pi(53_min)
    Interaction (263)
    WBProcess: WBbiopr:00000001
  Map_info: Map: II Position: 0.750204 Error: 0.00036
    Positive: Positive_clone: M110 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5120
        4617
        5014
    Pseudo_map_position
  Reference (33)
  Remark: ifg-1 related ESTs: Longest EST's: yk450c12, yk1009e02. Many other partial EST's. Person_evidence: WBPerson1666
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene