WormBase Tree Display for Gene: WBGene00000991

WBGene00000991 SMap: S_parent: Sequence: M03A8
  Identity: Version: 1
    Name: CGC_name: dhs-28 Person_evidence: WBPerson651
      Sequence_name: M03A8.1
      Molecular_name: M03A8.1
        M03A8.1.1
        CE04770
      Other_name: CELE_M03A8.1 Accession_evidence: NDB BX284606
      Public_name: dhs-28
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dhs
    Allele: WBVar02146417
      WBVar02159306
      WBVar01498964
      WBVar02124851
      WBVar02122483
      WBVar02146407
      WBVar02146408
      WBVar02146409
      WBVar02146410
      WBVar02146411
      WBVar02146412
      WBVar02146413
      WBVar02146414
      WBVar02146415
      WBVar02146416
      WBVar02146418
      WBVar02146419
      WBVar02146420
      WBVar02146421
      WBVar01156822
      WBVar00251445
      WBVar01156823
      WBVar01156824
      WBVar01156825
      WBVar01156826
      WBVar01156827
      WBVar01820160
      WBVar01156828
      WBVar01156829
      WBVar00087888
      WBVar01156830
      WBVar00034941
      WBVar00087889
      WBVar00087890
      WBVar00087891
      WBVar02120886
      WBVar02122728
      WBVar00091741
      WBVar00506998
      WBVar00506999
      WBVar00507000
      WBVar02064447
      WBVar01815814
      WBVar01500067
    Strain: WBStrain00035626
      WBStrain00040189
      WBStrain00050737
      WBStrain00050738
      WBStrain00050736
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (37)
    Paralog (38)
    Structured_description: Concise_description: dhs-28 encodes an ortholog of human 17-BETA-HYDROXYSTEROID DEHYDROGENASE 4 (HSD17B4; OMIM:601860, mutated in D-bifunctional protein deficiency), which contains a C-terminal SCP-2 sterol transfer domain; the deletion allele dhs-28(ok450) is superficially wild-type. Paper_evidence: WBPaper00004424
          Curator_confirmed: WBPerson48
            WBPerson1823
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable oxidoreductase activity. Involved in several processes, including carbohydrate derivative metabolic process; dauer entry; and positive regulation of developmental process. Located in peroxisome. Expressed in hypodermis. Used to study obesity. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Is an ortholog of human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9970 Homo sapiens Paper_evidence: WBPaper00035972
          Curator_confirmed: WBPerson38202
          Date_last_updated: 29 Jun 2018 00:00:00
    Potential_model: DOID:13366 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5213)
      DOID:0090031 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5213)
      DOID:0050857 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5213)
  Models_disease_asserted: WBDOannot00000570
    WBDOannot00000571
  Molecular_info: Corresponding_CDS: M03A8.1
    Corresponding_transcript: M03A8.1.1
    Other_sequence (107)
    Associated_feature: WBsf648263
      WBsf648264
      WBsf662918
      WBsf235872
      WBsf235873
  Experimental_info: RNAi_result: WBRNAi00108444 Inferred_automatically: RNAi_primary
      WBRNAi00008998 Inferred_automatically: RNAi_primary
      WBRNAi00050847 Inferred_automatically: RNAi_primary
      WBRNAi00034393 Inferred_automatically: RNAi_primary
      WBRNAi00025981 Inferred_automatically: RNAi_primary
      WBRNAi00092604 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8991
      Expr1020554
      Expr1030616
      Expr1154542
      Expr2010912
      Expr2029151
    Drives_construct: WBCnstr00013659
      WBCnstr00037154
    Construct_product: WBCnstr00013659
      WBCnstr00023002
      WBCnstr00037154
    Antibody: WBAntibody00001955
      WBAntibody00002918
    Microarray_results (27)
    Expression_cluster: WBPaper00028451:Low_abundance_spermatogenesis_enriched
      WBPaper00028802:intestine_unique
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032031:DConiospora_downregulated_OligoArray_24h
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033444:BacteriaDiet_regulated
      WBPaper00035073:mitochondria_protein
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_CoreEnriched
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_embryo_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00044260:1-methylnicotinamide_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_Day5
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00046121:endoderm_unique
      WBPaper00046303:P.aeruginosa_upregulated_protein
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00046691:P1_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050448:KGB-1-induced
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_HighSalt
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053094:adr-2(ok735)_neuron_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053318:mir-71(n4115)_upregulated_mRNA
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053615:SMO-1_target
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053814:OP50_vs_PY79_downregulated_PY79
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Rapamycin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056284:ints-1(RNAi)_upregulated
      WBPaper00056284:ints-4(RNAi)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056900:PID-3_interacting
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00056997:NMAD-1_interacting
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00060683:hlh-11(overexpression)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00060911:prx-5(RNAi)_upregulated_protein
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061045:Y56A3A.22(cck200)_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061221:H4K8ac_interacting
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061340:Intestine
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:MYRF-2_interacting
      WBPaper00061527:C24A3.4_16071-ech-8
      WBPaper00061527:dhs-28_22199-acs-14
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062590:Aging_downregulated_hypodermis
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064122:vulva_transcriptome
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064257:UNG-1_interacting
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064871:PA14_upregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065746:eat-2(ad1113)_downregulated
      WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:33_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_1_4
      cgc4489_group_8
      WBPaper00005124:estrogen_10-5M_regulated
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025032:cluster_12
      WBPaper00025032:cluster_16
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028789:PA14_vs_OP50_upregulated_4hr
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031850:mdt-15(RNAi)_downregulated
      WBPaper00034661:AgNPs_upregulated
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00036286:Pattern_C
      WBPaper00037695:WC_5-day
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00045015:acs-3(ft5)_upregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045673:colistin_upregulated
      [cgc5767]:cluster_5
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(83_min)
      [cgc6390]:Cluster_C
    Interaction (99)
  Map_info: Map: X Position: -2.40245 Error: 0.010942
    Positive: Positive_clone: M03A8 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4258
        4343
        5031
    Pseudo_map_position
  Reference (31)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene