WormBase Tree Display for Gene: WBGene00000591

WBGene00000591 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: K08A8
  Identity: Version: 1
    Name: CGC_name: coh-1
      Sequence_name: K08A8.3
      Molecular_name (12)
      Other_name: rad-21.2
        CELE_K08A8.3 Accession_evidence: NDB BX284606
      Public_name: coh-1
    DB_info: Database: AceView gene XI84
        WormQTL gene WBGene00000591
        WormFlux gene WBGene00000591
        NDB locus_tag CELE_K08A8.3
        Panther gene CAEEL|Gene_ORFName=CELE_K08A8.3|UniProtKB=A0A131MBD0
          family PTHR12585
        NCBI gene 181003
        RefSeq protein NM_001322622.4
            NM_076861.8
            NM_001322623.4
            NM_001381024.1
        TrEMBL UniProtAcc A0A131MBB4
            A0A131MBD0
            A0A131MCR9
            A0A131MBV3
        UniProt_GCRP UniProtAcc A0A131MBD0
        OMIM gene 606462
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: coh
    Allele: WBVar01526860
      WBVar00508516
      WBVar02152161
      WBVar00508517
      WBVar01526861
      WBVar00508518
      WBVar00508519
      WBVar00508520
      WBVar00508521
      WBVar00508522
      WBVar00508523
      WBVar00508524
      WBVar01160981
      WBVar00508525
      WBVar01160982
      WBVar01160983
      WBVar00599139
      WBVar01160984
      WBVar00599140
      WBVar01160985
      WBVar01160986
      WBVar01160987
      WBVar01160988
      WBVar01160989
      WBVar01160990
      WBVar01160991
      WBVar01160992
      WBVar01160993
      WBVar01160994
      WBVar01160995
      WBVar01160996
      WBVar01160997
      WBVar01160998
      WBVar01160999
      WBVar01161000
      WBVar01487215
      WBVar01161001
      WBVar01161002
      WBVar01161003
      WBVar01161004
      WBVar01883500
      WBVar01161005
      WBVar01883501
      WBVar01161006
      WBVar01883502
      WBVar01161007
      WBVar01883503
      WBVar01161008
      WBVar01883504
      WBVar01161009
      WBVar01883505
      WBVar01161010
      WBVar01883506
      WBVar01161011
      WBVar01161012
      WBVar00099061
      WBVar01161013
      WBVar01161014
      WBVar00099062
      WBVar00099063
      WBVar01161015
      WBVar00099064
      WBVar01161016
      WBVar01161017
      WBVar00099065
      WBVar01161018
      WBVar00099066
      WBVar01161019
      WBVar01161020
      WBVar01499933
      WBVar01161021
      WBVar01161022
      WBVar01499934
      WBVar01161023
      WBVar01161024
      WBVar00276917
      WBVar01161025
      WBVar01161026
      WBVar01161027
      WBVar01161028
      WBVar01161029
      WBVar01161030
      WBVar01161031
      WBVar00236393
      WBVar01499760
      WBVar01161032
      WBVar02046548
      WBVar01499761
      WBVar02046549
      WBVar01494253
      WBVar02111473
      WBVar00233654
      WBVar00049401
      WBVar00049406
      WBVar00049411
      WBVar00317111
      WBVar00049416
      WBVar00049421
      WBVar01835728
      WBVar01497959
      WBVar01835729
      WBVar00049426
      WBVar01980924
      WBVar01980925
      WBVar00249617
      WBVar00049431
      WBVar01980926
      WBVar00249619
      WBVar00049436
      WBVar02064763
      WBVar02064764
      WBVar00049446
      WBVar00049451
      WBVar00049456
      WBVar01601945
      WBVar01550502
      WBVar00080522
      WBVar00080523
      WBVar00080524
      WBVar00080525
      WBVar00080526
      WBVar00256480
      WBVar01849143
      WBVar01758761
      WBVar01758762
      WBVar00245504
      WBVar01849144
      WBVar02047766
      WBVar01849145
      WBVar01849146
      WBVar01849147
      WBVar02027214
      WBVar01815980
      WBVar01927300
      WBVar01927301
      WBVar01927302
      WBVar01927303
      WBVar01499867
      WBVar00508499
      WBVar00508500
      WBVar00508501
      WBVar01499869
      WBVar00508502
      WBVar00508503
      WBVar00508504
      WBVar00508505
      WBVar00508506
      WBVar00508507
      WBVar00508508
      WBVar00508509
      WBVar00508510
      WBVar00508511
      WBVar00508512
      WBVar00508513
      WBVar01526858
      WBVar00508514
      WBVar01526859
      WBVar01500067
      WBVar00508515
    Legacy_information: Paralogue of S.pombe rad21
      [J. Loidl] RNAi phenotypes\: ~80% embryo lethality, HIM (~2% males); protein localizes to somatic nuclei of the embryo and the distal tip cell of the gonad
      (K08A8.3) is homolog to the Rad21/Scc1/Rec8 family of cohesion proteins with known members in S. cerevisiae, S. pombe, A. thaliana and vertebrates. R-S-R is the acronym of the founder family
    RNASeq_FPKM (74)
    GO_annotation: 00001983
      00001984
      00001985
      00001986
      00001991
      00001992
      00107606
      00107607
    Ortholog (36)
    Paralog: WBGene00004737 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
    Structured_description: Concise_description: coh-1 encodes a RAD21 homolog that affects embryonic viability and is believed to affect cohesion of sister chromatids in somatic cells; expressed in the distal tip cells of the gonad, embryonic, and somatic cells Paper_evidence: WBPaper00004722
          Curator_confirmed: WBPerson48
          Date_last_updated: 09 Aug 2004 00:00:00
      Automated_description: Predicted to enable chromatin binding activity. Predicted to be involved in replication-born double-strand break repair via sister chromatid exchange and sister chromatid cohesion. Predicted to be located in nucleus. Predicted to be part of cohesin complex. Expressed in several structures, including anterior distal tip cell; anterior gonad arm; germ line; and posterior distal tip cell. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; carcinoma (multiple); and endometrial cancer. Is an ortholog of human RAD21 (RAD21 cohesin complex component) and RAD21L1 (RAD21 cohesin complex component like 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080508 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9811)
      DOID:0050866 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9811)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9811)
      DOID:0080199 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9811)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9811)
      DOID:1380 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9811)
  Molecular_info: Corresponding_CDS: K08A8.3a
      K08A8.3b
      K08A8.3c
      K08A8.3d
    Corresponding_CDS_history: K08A8.3:wp252
    Corresponding_transcript: K08A8.3a.1
      K08A8.3b.1
      K08A8.3c.1
      K08A8.3d.1
    Other_sequence (18)
    Associated_feature: WBsf670724
      WBsf1005848
      WBsf1005849
      WBsf1005850
      WBsf1005851
      WBsf1005852
      WBsf1023254
      WBsf1023255
      WBsf1023256
      WBsf1023257
  Experimental_info: RNAi_result (14)
    Expr_pattern: Expr1349
      Expr2580
      Expr13113
      Expr1026085
      Expr1030346
      Expr1153915
      Expr2010297
      Expr2028539
    Drives_construct: WBCnstr00037443
    Construct_product: WBCnstr00037443
    Antibody: WBAntibody00000372
      WBAntibody00000643
      WBAntibody00000644
    Microarray_results (26)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050094:glp-1(gf)_upregulated
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00052987:UV_upregulated_xpc-1;csb-1
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056855:his-72(uge40)_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061340:ABarpaaa_lineage
      WBPaper00061340:Glia
      WBPaper00061340:Neuroblast_IL1_IL2
      WBPaper00061340:Parent_of_AMsh_URB
      WBPaper00061340:Parent_of_hyp3_ILsoDx
      WBPaper00061340:RME
      WBPaper00061340:RMED
      WBPaper00061340:RME_LR_parent
      WBPaper00061340:URA_parent
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00061527:tub-2_4713-daf-2_5288
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_downregulated_protein
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-3(bn199)_upregulated_PGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065158:AFD_enriched
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066093:E.coli-purE_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      cgc4489_group_23
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_3
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Cadmium_regulated
      WBPaper00036286:Pattern_F
      WBPaper00037611:GLD-2-associated
      WBPaper00040963:TA100_down
      WBPaper00040963:TA300_down
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00045263:0.1mM-paraquat_upregulated
    Interaction (81)
  Map_info: Map: X Position: -1.6802 Error: 0.004761
    Positive: Positive_clone: K08A8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4486
        5066
        5498
    Pseudo_map_position
  Reference: WBPaper00005937
    WBPaper00012000
    WBPaper00018377
    WBPaper00026804
    WBPaper00027033
    WBPaper00031300
    WBPaper00038491
    WBPaper00055090
  Remark: Sequence connection from [Sugimoto A]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene