WormBase Tree Display for Gene: WBGene00000534

WBGene00000534 SMap: S_parent: Sequence: R01B10
  Identity: Version: 2
    Name: CGC_name: cpi-2 Paper_evidence: WBPaper00026724
            WBPaper00005846
            WBPaper00024997
          Person_evidence: WBPerson4368
            WBPerson390
      Sequence_name: R01B10.1
      Molecular_name: R01B10.1a
        R01B10.1a.1
        CE25962
        R01B10.1b
      Other_name: cli-1
        CELE_R01B10.1 Accession_evidence: NDB BX284605
      Public_name: cpi-2
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 04 Jan 2006 11:04:12 WBPerson2970 Name_change: CGC_name: cpi-2
                Other_name: cli-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cpi
    Allele: WBVar00210049
      WBVar00092502
      WBVar01499528
      WBVar01499173
      WBVar01499174
      WBVar01499740
      WBVar01500129
      WBVar00310175
      WBVar00459692
      WBVar00459693
      WBVar00459694
      WBVar00459695
      WBVar01740410
      WBVar00598901
      WBVar02124237
      WBVar01499496
      WBVar01016008
      WBVar01499316
      WBVar01016009
      WBVar01016010
      WBVar01016011
      WBVar01973713
      WBVar01016012
      WBVar01016013
      WBVar01016014
      WBVar01016015
      WBVar01016016
      WBVar01651823
      WBVar02122250
      WBVar01500066
    Strain: WBStrain00031908
      WBStrain00054915
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (48)
    Paralog: WBGene00000535 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016523 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00023486 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Enables cysteine-type endopeptidase inhibitor activity. Involved in positive regulation of vitellogenesis; regulation of oocyte development; and regulation of protein processing. Located in extracellular space and yolk granule. Expressed in hypodermis; pharyngeal gland cell; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; CST3-related cerebral amyloid angiopathy; artery disease (multiple); and autoimmune disease of the nervous system (multiple). Is an ortholog of several human genes including CST1 (cystatin SN); CST2 (cystatin SA); and CST3 (cystatin C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (17)
  Molecular_info: Corresponding_CDS: R01B10.1a
    Corresponding_transcript: R01B10.1b
      R01B10.1a.1
    Other_sequence (85)
    Associated_feature: WBsf028073
      WBsf646851
      WBsf655095
      WBsf661303
      WBsf661304
      WBsf661305
      WBsf1000163
      WBsf231832
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr3711
      Expr7868
      Expr7869
      Expr1020802
      Expr1030320
      Expr1154795
      Expr2010490
      Expr2028730
    Drives_construct: WBCnstr00012962
    Construct_product: WBCnstr00012962
    Antibody: WBAntibody00001122
    Microarray_results (31)
    Expression_cluster: WBPaper00005700:secreted_protein
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_Day5
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00045420:fertilization_downregulated_protein
      WBPaper00045521:Gender_Neutral
      WBPaper00045971:tunicamycin_upregulated_RtcB(null)
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046497:B.thuringiensis_upregulated_protein
      WBPaper00048926:miaserin_upregulated_adult-day5
      WBPaper00048988:neuron_expressed
      WBPaper00049018:ham-3(RNAi)_downregulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053289:DREAM-target
      WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_upregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_protein
      WBPaper00059471:EGL-43_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00061274:hypergravity_15xg_downregulated
      WBPaper00061340:Coelomocyte
      WBPaper00061340:DD
      WBPaper00061340:g1A_g1P
      WBPaper00061340:GLR
      WBPaper00061340:hmc
      WBPaper00061340:hmc_and_homolog
      WBPaper00061340:hmc_homolog
      WBPaper00061340:Parent_of_PVP_and_rect_V
      WBPaper00061340:rect_D
      WBPaper00061340:RMED
      WBPaper00061340:Z1_Z4
      WBPaper00061527:172183_at-176110_at
      WBPaper00061527:fbxc-28-sdz-28
      WBPaper00061651:CAN_enriched
      WBPaper00061651:Coelomocyte_enriched
      WBPaper00061651:DVB_enriched
      WBPaper00061651:VC_4_5_enriched
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064716:paraquat_downregulated
      WBPaper00064735:bet-1(RNAi)_vs_N2_upregulated
      WBPaper00064952:Day5_vs_L4_upregulated_25C
      WBPaper00064952:Day10_vs_L4_upregulated_25C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_21
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026980:intestine_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036286:Pattern_F
      WBPaper00037113:CPF_16C_down-regulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
    Interaction: WBInteraction000143932
      WBInteraction000306622
      WBInteraction000552020
      WBInteraction000577508
  Map_info: Map: V Position: -0.400385 Error: 0.008156
    Positive: Positive_clone: R01B10 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4964
        4240
    Pseudo_map_position
  Reference (12)
  Remark: Sequence connection from [Hashmi S, Lustigan S], [krb 020711]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene