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WormBase Tree Display for Gene: WBGene00004210

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Name Class

WBGene00004210EvidenceCGC_data_submission
SMapS_parentSequenceY110A2AL
IdentityVersion1
NameCGC_nameptc-3Person_evidenceWBPerson349
Sequence_nameY110A2AL.8
Molecular_nameY110A2AL.8a
Y110A2AL.8a.1
CE37163
Y110A2AL.8b
CE37164
Y110A2AL.8c
CE42182
Y110A2AL.8b.1
Y110A2AL.8c.1
Other_nameY110A2AL.jCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_Y110A2AL.8Accession_evidenceNDBBX284602
Public_nameptc-3
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:34WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classptc
AlleleWBVar01846596
WBVar01499702
WBVar01576570
WBVar01993906
WBVar01790569
WBVar01790570
WBVar01790571
WBVar01790572
WBVar01790573
WBVar01790574
WBVar01826530
WBVar00265925
WBVar00265926
WBVar02113443
WBVar01412949
WBVar01412950
WBVar01412952
WBVar02084557
WBVar01490712
WBVar02028966
WBVar02121367
WBVar02092107
WBVar01915927
WBVar02092108
WBVar01915928
WBVar01500106
WBVar02097634
WBVar01243252
WBVar01243263
WBVar01499387
WBVar01499388
WBVar01243274
WBVar02119923
WBVar02124159
WBVar00251790
WBVar01365407
WBVar00167996
WBVar00167997
WBVar01365416
WBVar02108705
WBVar00167998
WBVar00167999
WBVar00168000
WBVar00360286
WBVar00168001
WBVar00360287
WBVar00168002
WBVar00360288
WBVar00168003
WBVar00714992
WBVar00360289
WBVar00168004
WBVar00714993
WBVar00360290
WBVar00168005
WBVar00168006
WBVar00360291
WBVar00714994
WBVar00360292
WBVar00168007
WBVar00714995
WBVar00360293
WBVar00714996
WBVar00168008
WBVar00714997
WBVar00360294
WBVar02017709
WBVar00268316
WBVar00714998
WBVar00360295
WBVar00360296
WBVar00714999
WBVar00715000
WBVar00360297
WBVar00715001
WBVar00360298
WBVar00236971
WBVar00360299
WBVar01493346
WBVar00715002
WBVar00236972
WBVar00360300
WBVar01765138
WBVar00715003
WBVar01765139
WBVar00715004
WBVar00360301
WBVar01765140
WBVar00715005
WBVar00360302
WBVar00360303
WBVar00715006
WBVar00360304
WBVar00715007
WBVar00715008
WBVar00277520
WBVar01393071
WBVar00715009
WBVar00715010
WBVar01393074
WBVar01959558
WBVar00715011
WBVar01234165
WBVar01959559
WBVar01234166
WBVar00715012
WBVar01959560
WBVar01234168
WBVar00715013
WBVar01234169
WBVar00715014
WBVar01234170
WBVar00715015
WBVar00715016
WBVar01234173
WBVar00715017
WBVar00715018
WBVar01300081
WBVar01234176
WBVar00715019
WBVar01234178
WBVar01300103
WBVar01234183
WBVar00715020
WBVar02122912
WBVar00715021
WBVar01234186
WBVar00715022
WBVar01234189
WBVar00715023
WBVar00715024
WBVar00715025
WBVar00715026
WBVar00715028
WBVar00715029
WBVar00547330
WBVar00715030
WBVar02068108
WBVar01503679
WBVar00715031
WBVar02111696
WBVar00248319
WBVar01503680
WBVar00715032
WBVar00715033
WBVar01503681
WBVar01503682
WBVar00715034
WBVar00715035
WBVar01503683
WBVar00715036
WBVar01503684
WBVar02129565
WBVar01503685
WBVar00715037
WBVar02129566
WBVar01503686
WBVar00715038
WBVar00715039
WBVar00715040
WBVar01988956
WBVar00715041
WBVar01718930
WBVar00715042
WBVar01718931
WBVar02052763
WBVar01718932
WBVar00715043
WBVar01536745
WBVar00715044
WBVar01536746
WBVar00715045
WBVar00715046
WBVar01817611
WBVar01817612
WBVar00305119
WBVar01894888
WBVar01894889
WBVar01894890
WBVar01404429
WBVar01436716
WBVar01436718
WBVar00215119
WBVar00215120
WBVar00215121
WBVar02123883
WBVar00215122
WBVar00215123
WBVar00215124
WBVar00215125
WBVar02045532
WBVar01934081
WBVar02035537
WBVar00100750
WBVar00100751
RNASeq_FPKM (74)
GO_annotation (14)
Ortholog (41)
Paralog (31)
Structured_descriptionConcise_descriptionptc-3 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH(OMIM:601309, mutated in basal cell nevus syndrome), which defines oneof seven paralogous families of sterol sensing domain (SSD) proteins;PTC-3 is strongly required for normal molting from L1 to L3 larvalstages; PTC-3 is also required for normal growth to full size and forviability.Paper_evidenceWBPaper00004265
WBPaper00026841
WBPaper00027263
Curator_confirmedWBPerson567
Date_last_updated08 Nov 2006 00:00:00
Automated_descriptionPredicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in molting cycle. Located in apical plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CEP; cloaca; egg-laying apparatus; excretory duct; and preanal ganglion. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and holoprosencephaly 7. Is an ortholog of human PTCH1 (patched 1) and PTCH2 (patched 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:4195Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:2512Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:0070365Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:10534Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:0050860Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:0110876Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:5522Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:4948Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:3910Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:3748Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:0050902Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9586)
DOID:10460Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:2513Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585,HGNC:9586)
DOID:1793Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:0080016Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:3907Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
DOID:4621Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:9585)
Molecular_infoCorresponding_CDSY110A2AL.8a
Y110A2AL.8b
Y110A2AL.8c
Corresponding_CDS_historyY110A2AL.8a:wp127
Y110A2AL.8b:wp127
Corresponding_transcriptY110A2AL.8a.1
Y110A2AL.8b.1
Y110A2AL.8c.1
Other_sequence (34)
Associated_feature (13)
Experimental_infoRNAi_result (14)
Expr_patternExpr9231
Expr9232
Expr1017786
Expr1032067
Expr1158842
Expr2015145
Expr2033383
Drives_constructWBCnstr00008494
WBCnstr00008496
WBCnstr00035634
Construct_productWBCnstr00008494
WBCnstr00008495
WBCnstr00008496
WBCnstr00008497
WBCnstr00008498
WBCnstr00008502
WBCnstr00035634
AntibodyWBAntibody00002998
Microarray_results (31)
Expression_clusterWBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037682:sma-2_sma-4_upregulated
WBPaper00037950:germline-precursors_embryo_enriched
WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
WBPaper00037950:hypodermis_CoreEnriched
WBPaper00037950:hypodermis_embryo_enriched
WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
WBPaper00037950:hypodermis_larva_enriched
WBPaper00037950:hypodermis_larva_SelectivelyEnriched
WBPaper00038168:lin-15B(n744)_downregulated
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00040209:B.thuringiensis_downregulated_MY18
WBPaper00041954:ethanol_upregulated
WBPaper00043945:MeHg_upregulated
WBPaper00044260:1-methylnicotinamide_upregulated
WBPaper00044736:oscillating_dev_expression
WBPaper00045417:128Q-huntingtin_downreglated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Oogenic
WBPaper00046121:ecdoderm_unique
WBPaper00046499:AMPK_regulated
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048690:gonad-male-biased
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049018:swsn-2.2(RNAi)_downregulated
WBPaper00049594:osm-9(ok1677)_upregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00050370:dpy-21(e428)_L3_downregulated
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050990:hypodermis_enriched
WBPaper00050990:hypodermis_expressed
WBPaper00051021:4-bromodiphenyl-ether_upregulated
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051265:F4_hrde-1(tm1200)_upregulated
WBPaper00053020:OrsayVirus-infection_downregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster5
WBPaper00053615:SMO-1_target
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00055013:hmg-3(bar24)_downregulated
WBPaper00055013:spt-16(RNAi)_downregulated
WBPaper00055049:S.gordonii_upregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056169:rrf-3(pk1426)_downregulated_L4
WBPaper00056218:daf-16(mu86)_upregulated_Day7
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056290:mdt-15(mg584)_upregulated
WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
WBPaper00056330:glycine_downregulated
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
WBPaper00057068:numr-1(RNAi)_downregulated
WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00058725:sftb-1(cer39)_downregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059231:alh-6(lax105)_L4_upregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
WBPaper00059604:fluvastatin_downregulated_N2
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060445:nfki-1(cer1)_downregulated_L4
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061007:HB101_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:B_F_K_Kp_U_Y
WBPaper00061340:Hypodermis
WBPaper00061340:ILso
WBPaper00061340:Tail_hypodermis
WBPaper00061341:28C_24h_upregulated
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061479:hda-1(ne4748)_upregulated
WBPaper00061527:lon-8-C18D11.1_11630
WBPaper00061692:acivicin_upregulated
WBPaper00062118:neural-HSF-1_downregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062456:doxycycline_upregulated_CB4856_protein
WBPaper00062456:doxycycline_upregulated_N2_protein
WBPaper00062498:PPM-1.D_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mes-3(bn199)_upregulated_EGCs
WBPaper00064315:mes-4(bn73)_upregulated_EGCs
WBPaper00064532:pals-25(icb98)_downregulated
WBPaper00064539:nhr-114(gk849)_downregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065258:anchor-cell_enriched
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065841:0_0
WBPaper00065841:30_2
WBPaper00065841:33_0
WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
cgc4386_cluster_4_6
cgc4386_cluster_5_6
cgc4489_group_8
cgc4489_group_20
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:Resveratrol_regulated_N2
WBPaper00026980:intestine_enriched
WBPaper00028789:PA14_vs_OP50_upregulated_4hr
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031832:slr-2_regulated
WBPaper00032948:FedUp
WBPaper00032948:MoltOssilate
WBPaper00035084:embryo_enriched_AIN-2_IP
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035084:L2_enriched_AIN-2_IP
WBPaper00035084:L3_enriched_AIN-2_IP
WBPaper00035084:L4_enriched_AIN-2_IP
WBPaper00035227:heat_shock_regulated
WBPaper00035560:ahr-1_downregulated
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-8_regulated
WBPaper00035905:FBF-1_Associated
WBPaper00036130:mir-243_up_regulated
WBPaper00038172:crh-1null_down_regulated
WBPaper00038172:tax-6null_down_regulated
WBPaper00038304:octr-1_regulated
WBPaper00038427:lin-54_embryo_changed
WBPaper00040185:nhr-23(RNAi)_downregulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040876:mir-35_downregulated
WBPaper00040985:AIN-2_asynchronous_intestine
WBPaper00041174:genotypic
WBPaper00041174:genotypic_prime
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045673:colistin_upregulated
WBPaper00046083:oga-1(ok1207)_OP50_downregulated
WBPaper00046083:pmk-1(km25)_OP50_downregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00047070:N2_UV_downregulated
WBPaper00047070:xpa-1_UV_downregulated
WBPaper00048929:ethosuximide_upregulated
WBPaper00056330:mrps-5(RNAi)_upregulated
[cgc6390]:Cluster_B
[cgc6390]:male_soma-enriched
Interaction (78)
WBProcessWBbiopr:00000123
Map_infoMapIIPosition-9.82406Error0.084736
PositivePositive_cloneY110A2ALInferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (21)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene