WormBase Tree Display for Gene: WBGene00004729

WBGene00004729 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: sax-3 Person_evidence: WBPerson42
      Sequence_name: ZK377.2
      Molecular_name: ZK377.2a
        ZK377.2a.1
        CE25688
        ZK377.2b
        CE31267
        ZK377.2b.1
      Other_name: CELE_ZK377.2 Accession_evidence: NDB BX284606
      Public_name: sax-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 02 Mar 2018 11:09:16 WBPerson4025 Event: Split_into: WBGene00303098
      Split_into: WBGene00303098
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sax
    Allele: WBVar00088418 Inferred_automatically: From strain object: CX3171
      WBVar00088406 Inferred_automatically: From strain object: CX3198
          From strain object: IC361
          From strain object: IC459
          From strain object: IC464
          From strain object: IC476
          From strain object: IC699
      WBVar00499132
      WBVar01133888
      WBVar00499133
      WBVar01133889
      WBVar01133890
      WBVar00499134
      WBVar01133891
      WBVar00499135
      WBVar00499136
      WBVar01825047
      WBVar01133892
      WBVar00499137
      WBVar01133893
      WBVar00499138
      WBVar01133894
      WBVar00499139
      WBVar01133895
      WBVar01133896
      WBVar00499140
      WBVar01133897
      WBVar00499141
      WBVar00499142
      WBVar02056360
      WBVar01133898
      WBVar01133899
      WBVar00499143
      WBVar00077121
      WBVar00499144
      WBVar01133900
      WBVar00077122
      WBVar00499145
      WBVar01133901
      WBVar00077123
      WBVar00088416
      WBVar01133902
      WBVar00499146
      WBVar00499147
      WBVar01133903
      WBVar00088420
      WBVar01133904
      WBVar01133905
      WBVar01133906
      WBVar01133907
      WBVar01133908
      WBVar01133909
      WBVar01133910
      WBVar01133911
      WBVar01133912
      WBVar01133913
      WBVar01133914
      WBVar01133915
      WBVar01133916
      WBVar01133917
      WBVar01133918
      WBVar01133919
      WBVar01133920
      WBVar01133921
      WBVar01133922
      WBVar01133923
      WBVar01133924
      WBVar01133925
      WBVar01133926
      WBVar01819554
      WBVar01133927
      WBVar01133928
      WBVar01133929
      WBVar01133930
      WBVar01133931
      WBVar01133932
      WBVar01945140
      WBVar01133933
      WBVar01133934
      WBVar01133935
      WBVar01133936
      WBVar01133937
      WBVar01133938
      WBVar02026922
      WBVar02026923
      WBVar01133939
      WBVar02111081
      WBVar01133940
      WBVar01133941
      WBVar01133942
      WBVar02153697
      WBVar01133943
      WBVar01133944
      WBVar01133945
      WBVar01133946
      WBVar01133947
      WBVar01133948
      WBVar01486695
      WBVar02044495
      WBVar01133949
      WBVar02044496
      WBVar01133950
      WBVar01133951
      WBVar01133952
      WBVar01133953
      WBVar01133954
      WBVar01133955
      WBVar01133956
      WBVar01133957
      WBVar01133958
      WBVar01980154
      WBVar01133959
      WBVar01133960
      WBVar01133961
      WBVar01133962
      WBVar01133963
      WBVar01133964
      WBVar01133965
      WBVar01133966
      WBVar01133967
      WBVar01133968
      WBVar01133969
      WBVar01133970
      WBVar01133971
      WBVar01133972
      WBVar01133973
      WBVar01133974
      WBVar01133975
      WBVar01133976
      WBVar01133977
      WBVar01133978
      WBVar01133979
      WBVar01133980
      WBVar01133981
      WBVar01496664
      WBVar01133982
      WBVar01133983
      WBVar02152624
      WBVar01133984
      WBVar01133985
      WBVar01133986
      WBVar01601369
      WBVar01601370
      WBVar01601371
      WBVar01998626
      WBVar01499636
      WBVar01661389
      WBVar01468283
      WBVar01468284
      WBVar01468285
      WBVar01468286
      WBVar01468287
      WBVar02139019
      WBVar02139020
      WBVar00499117
      WBVar00499118
      WBVar00499119
      WBVar00499120
      WBVar00499121
      WBVar00499122
      WBVar00499123
      WBVar00499124
      WBVar00499125
      WBVar02148417
      WBVar00499126
      WBVar00499127
      WBVar02048722
      WBVar01133884
      WBVar00499128
      WBVar01133885
      WBVar00499129
      WBVar00499130
      WBVar01133886
      WBVar01500067
      WBVar01133887
      WBVar00499131
    Legacy_information: [Zallen JA] ky123 recessive, homozygotes exhibit aberrant anterior position of nerve ring, many ring axons misrouted, ventral nerve cord neurons often misrouted, cross midline. Encodes three isoforms, longest 1273 aa with 5 Ig repeats, 3 FNIII repeats, TM domain, large cytoplasmic domain. ky123 deletes signal sequence and first exon, probable null. Predicted gene ZK377.3 + ZK377.2
    Strain (11)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog: WBGene00034790 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00051982 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00148619 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00128991 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00104171 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00227726 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2329 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g12021 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g3884 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g10471 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g5898 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g8996 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g5061 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g9460 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g25465 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g16259 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00024.g1476 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_09429.g22059 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-sax-3 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_X.g23886 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g18177 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00313.g9231 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_00818.g15761 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_00829 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_00830 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_024104 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12222 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12223 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g8691 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0269800 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g18763 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00242200 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00267281 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00302741 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0041097 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
      FB:FBgn0005631 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      FB:FBgn0002543 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            PhylomeDB
      ZFIN:ZDB-GENE-000209-3 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-000209-4 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-001019-1 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1874 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:10249 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:10250 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:13433 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:1343102 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:1274781 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:1890110 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:61941 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:620167 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:1311018 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
    Paralog (22)
    Structured_description: Concise_description: sax-3 encodes, by alternative splicing, two isoforms of an ortholog of Drosophila ROUNDABOUT, ROBO3, and LEAK, and of human ROBO1, ROBO2 (OMIM:602431, mutated in vesicoureteral reflux), and ROBO3 (OMIM:608630, mutated in horizontal gaze palsy with progressive scoliosis); in larval hermaphrodites, SAX-3 is required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. Paper_evidence: WBPaper00003665
            WBPaper00004362
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 24 Jan 2008 00:00:00
      Automated_description: Enables axon guidance receptor activity. Involved in generation of neurons and regulation of sensory neuron axon guidance. Located in plasma membrane. Expressed in several structures, including QR.a; QR.p; body wall musculature; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital nystagmus; hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human ROBO1 (roundabout guidance receptor 1); ROBO2 (roundabout guidance receptor 2); and ROBO3 (roundabout guidance receptor 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (11)
  Molecular_info: Corresponding_CDS: ZK377.2a
      ZK377.2b
    Corresponding_CDS_history: ZK377.2c:wp264
    Corresponding_transcript: ZK377.2a.1
      ZK377.2b.1
    Other_sequence (32)
    Associated_feature (39)
  Experimental_info: RNAi_result: WBRNAi00086088 Inferred_automatically: RNAi_primary
      WBRNAi00086133 Inferred_automatically: RNAi_primary
      WBRNAi00009468 Inferred_automatically: RNAi_primary
      WBRNAi00009467 Inferred_automatically: RNAi_primary
      WBRNAi00067130 Inferred_automatically: RNAi_primary
      WBRNAi00059385 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram406
      Expr716
      Expr3685
      Expr7210
      Expr11154
      Expr13291
      Expr13760
      Expr13762
      Expr13763
      Expr14627
      Expr15406
      Expr15970
      Expr1011333
      Expr1032333
      Expr1162812
      Expr2015608
      Expr2033843
    Drives_construct: WBCnstr00001914
      WBCnstr00003185
      WBCnstr00006455
      WBCnstr00009445
      WBCnstr00012503
      WBCnstr00016209
      WBCnstr00035424
      WBCnstr00039977
      WBCnstr00041184
    Construct_product (15)
    Microarray_results (28)
    Expression_cluster (134)
    Interaction (262)
    Anatomy_function: WBbtf0177
  Map_info: Map: X Position: -10.3398 Error: 0.007528
    Well_ordered
    Positive: Inside_rearr: mnDp57
      Positive_clone: R06A1
        ZK377 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3695
        3696
        4758
      Pos_neg_data: 9401
  Reference (143)
  Remark: Inferred from Zallen et al. (1998)
    2 predicted genes (see phenotype) have been merged. [sdm 05/00]
  Method: Gene