WormBase Tree Display for Gene: WBGene00000857
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WBGene00000857 | SMap | S_parent | Sequence | K10B4 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | cwn-1 | Person_evidence | WBPerson1157 | |||||
Sequence_name | K10B4.6 | ||||||||
Molecular_name | K10B4.6a | ||||||||
K10B4.6a.1 | |||||||||
CE12072 | |||||||||
K10B4.6b | |||||||||
Other_name | Wnt-1 | Accession_evidence | EMBL | X72942 | |||||
X72941 | |||||||||
CELE_K10B4.6 | Accession_evidence | NDB | BX284602 | ||||||
Public_name | cwn-1 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | cwn | ||||||||
Allele | WBVar00091833 | Inferred_automatically (20) | |||||||
WBVar00089232 | |||||||||
WBVar00089231 | |||||||||
WBVar02122081 | |||||||||
WBVar00354175 | |||||||||
WBVar00354176 | |||||||||
WBVar00354177 | |||||||||
WBVar00354178 | |||||||||
WBVar01500106 | |||||||||
WBVar00262453 | |||||||||
WBVar00262459 | |||||||||
WBVar01498661 | |||||||||
WBVar00009016 | |||||||||
WBVar01532481 | |||||||||
WBVar01532482 | |||||||||
WBVar01532483 | |||||||||
WBVar00696793 | |||||||||
WBVar00696794 | |||||||||
WBVar00696795 | |||||||||
WBVar00696796 | |||||||||
WBVar00696797 | |||||||||
WBVar00696798 | |||||||||
WBVar00696799 | |||||||||
WBVar00162852 | |||||||||
WBVar00696800 | |||||||||
WBVar00162853 | |||||||||
WBVar01988568 | |||||||||
WBVar00696801 | |||||||||
WBVar00696802 | |||||||||
WBVar00696803 | |||||||||
WBVar00696804 | |||||||||
WBVar00696805 | |||||||||
WBVar00696806 | |||||||||
WBVar00696807 | |||||||||
WBVar01715444 | |||||||||
WBVar01291054 | |||||||||
WBVar01291055 | |||||||||
WBVar01291056 | |||||||||
WBVar01291057 | |||||||||
Legacy_information | [Shivakumar S, Jongeward G] early embryonic arrest. psoralen screen for lethals rescued by transgene including R180. encodes CeWnt1, a C. elegans wnt homolog. | ||||||||
[C.elegansII] mu109 : embryonic lethal, early arrest as disorganized embryo at 2-3 fold stage; allele obtained by psoralen screen for lethals rescued by cwn-1 transgene. OA1: mu110.Cloned: 1.4 kb transcript, transspliced; most abundant in embryo; encodes 372 aa Wnt homolog[Shackleford et al. 1993; CF] | |||||||||
Strain (21) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (55) | |||||||||
Ortholog (41) | |||||||||
Paralog | WBGene00003029 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00001188 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00000858 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00003395 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | cwn-1 encodes one of five C. elegans Wnt signaling ligands; during embryogenesis cwn-1 likely functions as a downstream target of the PAL-1 homeodomain protein in the regulatory network that specifies cell fates in the C lineage that gives rise to ectodermal and muscle tissue; consistent with this role, loss of cwn-1 activity via RNAi results in rare larval tail defects that may result, in part, from abnormal morphogenesis of C lineage descendants; a cwn-1 reporter is expressed in C and D muscle cells, as well as in two posterior C ectodermal cells; cwn-1 mRNA is detectable at all developmental stages, with highest levels of expression seen in embryonic stages. | Paper_evidence (3) | ||||||
Curator_confirmed | WBPerson1823 | ||||||||
WBPerson567 | |||||||||
WBPerson1843 | |||||||||
Date_last_updated | 27 Apr 2009 00:00:00 | ||||||||
Automated_description | Enables receptor tyrosine kinase binding activity. Involved in several processes, including neuroblast migration; neuron migration; and positive regulation of axon guidance. Predicted to be located in extracellular space. Expressed in several structures, including CAN; hypodermal cell; intestine; muscle cell; and somatic nervous system. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism and endometrial carcinoma. Is an ortholog of human WNT4 (Wnt family member 4). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:2871 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12783) | ||||
DOID:0111526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12783) | ||||||
Molecular_info | Corresponding_CDS | K10B4.6a | |||||||
Corresponding_CDS_history | K10B4.6b:wp247 | ||||||||
Corresponding_transcript | K10B4.6b | ||||||||
K10B4.6a.1 | |||||||||
Other_sequence (37) | |||||||||
Associated_feature (7) | |||||||||
Experimental_info | RNAi_result | WBRNAi00101447 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00069526 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069525 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069516 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069530 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00030250 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00101484 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069529 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069515 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069519 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00098908 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00101687 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00101703 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069521 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00101684 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069523 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069527 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069520 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00050490 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069524 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00101697 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069522 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069518 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00101779 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069517 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00101346 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00101682 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00069528 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00101692 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091573 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (20) | |||||||||
Drives_construct | WBCnstr00000557 | ||||||||
WBCnstr00008853 | |||||||||
WBCnstr00008923 | |||||||||
WBCnstr00009125 | |||||||||
WBCnstr00009817 | |||||||||
WBCnstr00012521 | |||||||||
WBCnstr00013047 | |||||||||
WBCnstr00014375 | |||||||||
WBCnstr00015214 | |||||||||
WBCnstr00016103 | |||||||||
WBCnstr00016629 | |||||||||
WBCnstr00016630 | |||||||||
WBCnstr00016635 | |||||||||
WBCnstr00016636 | |||||||||
WBCnstr00016637 | |||||||||
WBCnstr00018201 | |||||||||
WBCnstr00019091 | |||||||||
WBCnstr00020124 | |||||||||
WBCnstr00037246 | |||||||||
WBCnstr00042481 | |||||||||
Construct_product (15) | |||||||||
Microarray_results (23) | |||||||||
Expression_cluster (165) | |||||||||
Interaction (67) | |||||||||
WBProcess | WBbiopr:00000017 | ||||||||
WBbiopr:00000023 | |||||||||
WBbiopr:00000073 | |||||||||
Map_info | Map | II | Position | -15.9676 | Error | 0.013997 | |||
Positive | Positive_clone | K10B4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
R180 | |||||||||
Mapping_data | Multi_point | 4244 | |||||||
Pseudo_map_position | |||||||||
Reference (89) | |||||||||
Remark | replaces int-12, pcr clone isolated by Sasha Kamb. the accession numbers for these genes X72941 cwn-1 mRNA X72942 cwn-1 gene (introns included) | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |