WormBase Tree Display for Gene: WBGene00004862

WBGene00004862 Evidence: Paper_evidence: WBPaper00013343
  SMap: S_parent: Sequence: T05A10
  Identity: Version: 1
    Name: CGC_name: sma-9 Person_evidence: WBPerson261
      Sequence_name: T05A10.1
      Molecular_name (38)
      Other_name: CELE_T05A10.1 Accession_evidence: NDB BX284606
      Public_name: sma-9
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sma
    Allele: WBVar00275186
      WBVar00275183
      WBVar00275174
      WBVar00275179
      WBVar00275185
      WBVar00241220
      WBVar00082794
      WBVar01183464
      WBVar00082795
      WBVar01183465
      WBVar01183466
      WBVar00082796
      WBVar01897923
      WBVar01183467
      WBVar00082797
      WBVar01897924
      WBVar01183468
      WBVar00082799
      WBVar01183469
      WBVar00082800
      WBVar00082801
      WBVar01183470
      WBVar00082802
      WBVar01183471
      WBVar01183472
      WBVar01183473
      WBVar00092836
      WBVar01183474
      WBVar01183475
      WBVar01183476
      WBVar01183477
      WBVar01183478
      WBVar01183479
      WBVar00258008
      WBVar00515891
      WBVar00515892
      WBVar00515893
      WBVar01552045
      WBVar00515894
      WBVar01552046
      WBVar00515895
      WBVar00515896
      WBVar00515897
      WBVar00515898
      WBVar00515899
      WBVar00275575
      WBVar00515900
      WBVar00515901
      WBVar00275169
      WBVar00515902
      WBVar00064534
      WBVar00275579
      WBVar00515903
      WBVar00515904
      WBVar00515905
      WBVar00064539
      WBVar00515906
      WBVar00515907
      WBVar00515908
      WBVar00515909
      WBVar01489244
      WBVar00064544
      WBVar00515910
      WBVar00515911
      WBVar00515912
      WBVar00515913
      WBVar00515914
      WBVar00515915
      WBVar00515916
      WBVar01711118
      WBVar00515917
      WBVar00236742
      WBVar00515918
      WBVar00515919
      WBVar01946070
      WBVar02140027
      WBVar02140028
      WBVar01498845
      WBVar01496646
      WBVar01820520
      WBVar01183368
      WBVar01981279
      WBVar01981280
      WBVar01183369
      WBVar01183370
      WBVar01183371
      WBVar01183372
      WBVar01183373
      WBVar01183374
      WBVar01183375
      WBVar01183376
      WBVar00249609
      WBVar00069164
      WBVar01183377
      WBVar01183378
      WBVar01183379
      WBVar01183380
      WBVar01183381
      WBVar02066045
      WBVar02066046
      WBVar01183382
      WBVar02066047
      WBVar01183383
      WBVar01183384
      WBVar02066048
      WBVar01183385
      WBVar01183386
      WBVar01183387
      WBVar01183388
      WBVar01183389
      WBVar00241221
      WBVar01183390
      WBVar01620398
      WBVar01620399
      WBVar01183391
      WBVar01183392
      WBVar01620400
      WBVar01183393
      WBVar01620401
      WBVar01183394
      WBVar01183395
      WBVar01183396
      WBVar01183397
      WBVar01183398
      WBVar01183399
      WBVar01183400
      WBVar01183401
      WBVar01183402
      WBVar01183403
      WBVar01183404
      WBVar01183405
      WBVar01183406
      WBVar01183407
      WBVar01183408
      WBVar00277183
      WBVar01183409
      WBVar01183410
      WBVar01183411
      WBVar01183412
      WBVar01183413
      WBVar01183414
      WBVar01183415
      WBVar01183416
      WBVar01183417
      WBVar01183418
      WBVar01183419
      WBVar01470943
      WBVar01889127
      WBVar01470944
      WBVar01183420
      WBVar01889128
      WBVar01183421
      WBVar01889129
      WBVar02069069
      WBVar01183422
      WBVar01889130
      WBVar01183423
      WBVar01889131
      WBVar01889132
      WBVar01183424
      WBVar01889133
      WBVar01183425
      WBVar01183426
      WBVar01889134
      WBVar01602153
      WBVar01889135
      WBVar01183427
      WBVar01602154
      WBVar00099898
      WBVar01183428
      WBVar01889136
      WBVar01889137
      WBVar01183429
      WBVar01183430
      WBVar01889138
      WBVar01183431
      WBVar01183432
      WBVar01183433
      WBVar01183434
      WBVar01183435
      WBVar01183436
      WBVar01183437
      WBVar01759319
      WBVar01759320
      WBVar01183438
      WBVar01759321
      WBVar01183439
      WBVar01183440
      WBVar01183441
      WBVar01183442
      WBVar01183443
      WBVar01183444
      WBVar01183445
      WBVar01928230
      WBVar01183446
      WBVar01183447
      WBVar01183448
      WBVar01183449
      WBVar01183450
      WBVar01183451
      WBVar01183452
      WBVar01183453
      WBVar01183454
      WBVar01183455
      WBVar01183456
      WBVar01183457
      WBVar01183458
      WBVar01183459
      WBVar01183460
      WBVar01498960
      WBVar01183461
      WBVar01183462
      WBVar00082792
      WBVar01500067
      WBVar01183463
      WBVar00082793
    Legacy_information: [Savage-Dunn C] Small and Mab (sensory ray and spicule abnormalities).
    Complementation_data: [Savage-Dunn C] complements sma-5(n678)
    Strain (18)
    RNASeq_FPKM (74)
    GO_annotation (41)
    Contained_in_operon: CEOPX001
    Ortholog (43)
    Structured_description: Concise_description: sma-9 encodes, by extensive alternative splicing, at least 13 isoforms, a number of which are large (~2000-residue) proteins with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain; SMA-9 is orthologous to the Drosophila Smad cofactor Schnurri (FBgn0003396) and the vertebrate HIVEP proteins (Human Immunodeficiency Virus Type 1 Enhancer-Binding Proteins, OMIM:194540, OMIM:143054, and OMIM:606649); in C. elegans, sma-9 functions in a subset of the TGF-beta-mediated signaling pathways that regulate body size and male tail patterning and morphogenesis; sma-9, through this pathway, also regulates reproductive aging; studies have shown that a reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; sma-9 also functions antagonistically to the TGF-beta signaling pathway, and in parallel to the lin-12/Notch pathway, to effect proper cell fate specification in the postembryonic mesodermal lineage, the M lineage; SMA-9 is widely expressed and localizes to nuclei. Paper_evidence: WBPaper00005858
            WBPaper00006346
            WBPaper00027702
            WBPaper00029226
            WBPaper00035079
            WBPaper00035556
            WBPaper00037682
          Curator_confirmed: WBPerson1843
            WBPerson324
            WBPerson567
          Date_last_updated: 18 Jan 2011 00:00:00
      Automated_description: Enables transcription coactivator activity and transcription corepressor activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and regulation of gene expression. Acts upstream of or within cellular response to heat. Located in nucleus. Expressed in several structures, including excretory cell; intestine; spermatheca; ventral cord neurons; and vulva. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 43. Is an ortholog of human HIVEP1 (HIVEP zinc finger 1); HIVEP2 (HIVEP zinc finger 2); and HIVEP3 (HIVEP zinc finger 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:10652 Homo sapiens Paper_evidence: WBPaper00046027
          Curator_confirmed: WBPerson324
          Date_last_updated: 21 Sep 2018 00:00:00
    Potential_model: DOID:0070073 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4921)
  Models_disease_in_annotation: WBDOannot00000341
  Molecular_info: Corresponding_CDS (11)
    Corresponding_CDS_history (13)
    Corresponding_transcript: T05A10.1a.1
      T05A10.1b.1
      T05A10.1c.1
      T05A10.1c.2
      T05A10.1d.1
      T05A10.1e.1
      T05A10.1f.1
      T05A10.1g.1
      T05A10.1h.1
      T05A10.1h.2
      T05A10.1i.1
      T05A10.1j.1
      T05A10.1j.2
      T05A10.1j.3
      T05A10.1j.4
      T05A10.1m.1
    Other_sequence (328)
    Associated_feature (25)
    Gene_product_binds (41)
    Transcription_factor: WBTranscriptionFactor000847
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr2782
      Expr2783
      Expr3995
      Expr10436
      Expr1011744
      Expr1032413
      Expr1156052
      Expr1200018
      Expr2015897
      Expr2034130
    Drives_construct (15)
    Construct_product (11)
    Antibody: WBAntibody00000885
    Microarray_results (83)
    Expression_cluster (163)
    Interaction (82)
    WBProcess: WBbiopr:00000025
      WBbiopr:00000026
      WBbiopr:00000033
  Map_info: Map: X Position: 2.51785 Error: 0.028298
    Positive: Inside_rearr: nDf19
        yDp9
      Positive_clone: T05A10 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: mnDp1
        mnDf1
        yDp5
    Mapping_data: 2_point: 7096
        7097
        7099
      Pos_neg_data: 10243
        10244
        10245
        10246
        10247
  Reference (61)
  Picture: WBPicture0000013077
  Method: Gene