WormBase Tree Display for Variation: WBVar00249043

WBVar00249043 Evidence: Paper_evidence: WBPaper00035599
  Name: Public_name: sy705
    Other_name: sy704 Paper_evidence: WBPaper00035599
      sy710 Paper_evidence: WBPaper00035599
      F25H8.6.1:c.511C>T
      CE05731:p.Gln171Ter
    HGVSg: CHROMOSOME_IV:g.9917903C>T
  Sequence_details: SMap: S_parent: Sequence: F25H8
    Flanking_sequences: ATGATTCGCCACTTGAGAAGTTGTCATGTT aagagtatcagcttgtccaagaagctcgacagaa
    Mapping_target: F25H8
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00035599
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00030952
      WBStrain00056458
    Laboratory: PS
      CHB
    History: Acquires_merge: WBVar00249042
        WBVar00249044
    Status: Live
  Affects: Gene: WBGene00009133
    Transcript: F25H8.6.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: F25H8.6.1:c.511C>T
        HGVSp: CE05731:p.Gln171Ter
        cDNA_position: 534
        CDS_position: 511
        Protein_position: 171
        Exon_number: 4/10
        Codon_change: Caa/Taa
        Amino_acid_change: Q/*
    Interactor: WBInteraction000504243
  Isolation: Mutagen: EMS Paper_evidence: WBPaper00035599
  Genetics: Interpolated_map_position: IV 4.4464
  Description: Phenotype: WBPhenotype:0000006 Paper_evidence: WBPaper00035599
        Curator_confirmed: WBPerson2021
        Remark: bed-3 mutations caused an Egl (egg-laying defective) phenotype Paper_evidence: WBPaper00035599
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000111 Paper_evidence: WBPaper00035599
        Curator_confirmed: WBPerson2021
        Remark: bed-3(sy705) affected the vulval expression pattern of cdh-3::cfp Paper_evidence: WBPaper00035599
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000239 Paper_evidence: WBPaper00035599
        Curator_confirmed: WBPerson2021
        Remark: Granddaughters of P5.p, P6.p and P7.p often failed to divide in bed-3 mutants. bed-3(sy705) caused a specific loss of the third (terminal) division Paper_evidence: WBPaper00035599
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000638 Paper_evidence: WBPaper00035599
        Curator_confirmed: WBPerson2021
        Remark: bed-3 mutation also caused molting defects Paper_evidence: WBPaper00035599
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000697 Paper_evidence: WBPaper00035599
        Curator_confirmed: WBPerson2021
        Remark: Pvl Paper_evidence: WBPaper00035599
            Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000289 Paper_evidence: WBPaper00035599
        Curator_confirmed: WBPerson2021
        Remark: The gross morphology of the uterus was normal in the strongest bed-3 mutant, bed-3(sy705). No difference in the number of cog-2::gfp expressing cells in the wild type and bed-3 mutants Paper_evidence: WBPaper00035599
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000515 Paper_evidence: WBPaper00035599
        Curator_confirmed: WBPerson2021
        Remark: bed-3 mutations do not affect Pn.a lineages. Paper_evidence: WBPaper00035599
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000701 Paper_evidence: WBPaper00035599
        Curator_confirmed: WBPerson2021
        Remark: Same number of seam cell nuclei in bed-3(sy705) mutants as in the wild type Paper_evidence: WBPaper00035599
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005753 PATO:0000460 Paper_evidence: WBPaper00035599
                Curator_confirmed: WBPerson2021
  Reference: WBPaper00035599
    WBPaper00065979
  Method: Substitution_allele