WormBase Tree Display for Variation: WBVar00088448

WBVar00088448 Evidence: Paper_evidence: WBPaper00004669
  Name: Public_name: ky400
    Other_name: F59A6.1b.1:c.1582A>T
      CE50862:p.Lys528Ter
      CE44901:p.Lys542Ter
      F59A6.1a.1:c.1624A>T
    HGVSg: CHROMOSOME_II:g.5026025A>T
  Sequence_details: SMap: S_parent: Sequence: F33G12
    Flanking_sequences: agatacccagtacttattctggaactcaat aggaattcacaccttcttatctgactctga
    Mapping_target: F33G12
    Type_of_mutation: Substitution: a t
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: CX
    Status: Live
  Affects: Gene: WBGene00003822
    Transcript: F59A6.1a.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: F59A6.1a.1:c.1624A>T
        HGVSp: CE44901:p.Lys542Ter
        cDNA_position: 1781
        CDS_position: 1624
        Protein_position: 542
        Exon_number: 7/12
        Codon_change: Aag/Tag
        Amino_acid_change: K/*
      F59A6.1b.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: F59A6.1b.1:c.1582A>T
        HGVSp: CE50862:p.Lys528Ter
        cDNA_position: 1582
        CDS_position: 1582
        Protein_position: 528
        Exon_number: 6/11
        Codon_change: Aag/Tag
        Amino_acid_change: K/*
    Interactor: WBInteraction000501729
      WBInteraction000504796
      WBInteraction000517982
      WBInteraction000517983
  Genetics: Interpolated_map_position: II -2.59273
  Description: Phenotype: WBPhenotype:0000006 Paper_evidence: WBPaper00003760
        Curator_confirmed: WBPerson2021
        Remark: nsy-1 mutants are egg-laying defective Paper_evidence: WBPaper00003760
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00003760
          Curator_confirmed: WBPerson2021
      WBPhenotype:0000067 Paper_evidence: WBPaper00037959
        Curator_confirmed: WBPerson712
        Remark: Animals had a lower survival rate in the presence of stress-inducing drugs. Paper_evidence: WBPaper00037959
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00002747 Paper_evidence: WBPaper00037959
              Curator_confirmed: WBPerson712
            WBMol:00004565 Paper_evidence: WBPaper00037959
              Curator_confirmed: WBPerson712
            WBMol:00004592 Paper_evidence: WBPaper00037959
              Curator_confirmed: WBPerson712
      WBPhenotype:0001095 Paper_evidence: WBPaper00037959
        Curator_confirmed: WBPerson712
        Remark: Animals had a lower survival rate in the presence of stress-inducing conditions. Paper_evidence: WBPaper00037959
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00003571 Paper_evidence: WBPaper00037959
              Curator_confirmed: WBPerson712
      WBPhenotype:0001351 Paper_evidence: WBPaper00037959
        Curator_confirmed: WBPerson712
        Remark: Anoxia induced PMK-1 activation was suppressed in nsy-1 mutant. Paper_evidence: WBPaper00037959
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00005312 Paper_evidence: WBPaper00037959
              Curator_confirmed: WBPerson712
      WBPhenotype:0001381 Paper_evidence: WBPaper00037959
        Curator_confirmed: WBPerson712
        Remark: nsy-1(ky400) mutant animals showed a higher survival rate than the wild-type ones under anoxic conditions. Paper_evidence: WBPaper00037959
            Curator_confirmed: WBPerson712
      WBPhenotype:0001661 Paper_evidence: WBPaper00003760
        Curator_confirmed: WBPerson2021
        Remark: 2 AWC on Paper_evidence: WBPaper00003760
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00003760
          Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005672 PATO:0000460 Paper_evidence: WBPaper00003760
                Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000424 Paper_evidence: WBPaper00037959
        Curator_confirmed: WBPerson712
        Remark: The total amount of PMK-1 was assessed by an anti-PMK-1 antibody, and little difference was observed between the wild-type and nsy-1(ky400) mutant animals under the basal and stimulated conditions. Paper_evidence: WBPaper00037959
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00005312 Paper_evidence: WBPaper00037959
              Curator_confirmed: WBPerson712
      WBPhenotype:0000631 Paper_evidence: WBPaper00037959
        Curator_confirmed: WBPerson712
        Remark: nsy-1(ky400) mutant animals showed almost the same survival curve as wild-type animals under non-stressed conditions, as in the presence of 5-fluoro-2'-deoxyuridine. Paper_evidence: WBPaper00037959
            Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00003760
        Curator_confirmed: WBPerson2021
        Remark: nsy-1 mutants are coordinated Paper_evidence: WBPaper00003760
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00003760
          Curator_confirmed: WBPerson2021
  Reference: WBPaper00037959
    WBPaper00003760
    WBPaper00004669
  Method: Substitution_allele