WormBase Tree Display for Gene: WBGene00003822
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| WBGene00003822 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 4 | |||||||
| Name | CGC_name | nsy-1 | Person_evidence | WBPerson42 | |||||
| Sequence_name | F59A6.1 | ||||||||
| Molecular_name | F59A6.1a | ||||||||
| F59A6.1a.1 | |||||||||
| CE44901 | |||||||||
| F59A6.1b | |||||||||
| CE50862 | |||||||||
| F59A6.1b.1 | |||||||||
| Other_name | esp-8 | ||||||||
| ask-1 | |||||||||
| xts-1 | Person_evidence | WBPerson9709 | |||||||
| srf-6 | |||||||||
| CELE_F59A6.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | nsy-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 25 Oct 2016 10:44:04 | WBPerson2970 | Name_change | Other_name | xts-1 | ||||
| 3 | 02 Mar 2018 10:40:21 | WBPerson4025 | Event | Split_into | WBGene00303064 | ||||
| 4 | 02 Aug 2019 15:22:42 | WBPerson1983 | Name_change | Other_name | srf-6 | ||||
| Split_into | WBGene00303064 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nsy | ||||||||
| Allele (121) | |||||||||
| Legacy_information | ky400 homozygotes lose neuronal asymmetry, express str-2::GFPin both AWC neurons. ky542, ky397 similar.All 3 probable nulls: stop codons in F59A6.1, encoding homolog of Human MAPKKK ASK1. | ||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (59) | |||||||||
| Ortholog (51) | |||||||||
| Paralog | WBGene00004161 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | nsy-1 encodes a MAP kinase kinase kinase (MAP3K) that is orthologous to the mammalian apoptosis signal-regulating kinase (ASK) family of protein kinases; nsy-1 activity is required for chemotaxis, egg laying, pathogen response, and response to anoxia; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; NSY-1 interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons. | Paper_evidence | WBPaper00003760 | |||||
| WBPaper00004610 | |||||||||
| WBPaper00004669 | |||||||||
| WBPaper00005370 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 11 Jan 2011 00:00:00 | ||||||||
| Automated_description | Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and positive regulation of macromolecule biosynthetic process. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Expressed in head; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease and perinatal necrotizing enterocolitis. Is an ortholog of human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:670 | Homo sapiens | Paper_evidence | WBPaper00038418 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 31 May 2019 00:00:00 | ||||||||
| Potential_model | DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6857) | |||||
| DOID:8677 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6857) | ||||||
| Models_disease_asserted | WBDOannot00000693 | ||||||||
| Molecular_info | Corresponding_CDS | F59A6.1a | |||||||
| F59A6.1b | |||||||||
| Corresponding_CDS_history | F59A6.1c:wp264 | ||||||||
| Corresponding_transcript | F59A6.1a.1 | ||||||||
| F59A6.1b.1 | |||||||||
| Other_sequence (29) | |||||||||
| Associated_feature | WBsf657564 | ||||||||
| WBsf987777 | |||||||||
| WBsf987778 | |||||||||
| WBsf987779 | |||||||||
| WBsf987780 | |||||||||
| WBsf1012168 | |||||||||
| WBsf1012169 | |||||||||
| WBsf221219 | |||||||||
| Experimental_info (11) | |||||||||
| Map_info | Map | II | Position | -2.59263 | Error | 0.001611 | |||
| Positive | Inside_rearr | ccDf2 | |||||||
| maDf4 | |||||||||
| Positive_clone | F59A6 | Author_evidence | Sagasti A | ||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Negative | Outside_rearr | ccDf11 | |||||||
| Mapping_data | Pos_neg_data | 10652 | |||||||
| 10653 | |||||||||
| 10654 | |||||||||
| 10655 | |||||||||
| Reference (158) | |||||||||
| Picture | WBPicture0000013079 | ||||||||
| WBPicture0000013081 | |||||||||
| WBPicture0000013093 | |||||||||
| Remark | Sequence connection (nsy-1 = F59A6.1) from Sagasti A and Bargmann C [030204 ck1] | ||||||||
| Method | Gene |
