WormBase Tree Display for Interaction: WBInteraction000558284

WBInteraction000558284 Interaction_type: Regulatory: Change_of_localization
  Interactor: Interactor_overlapping_gene: WBGene00006882 Interactor_type: Trans_regulated
        Transgene: WBTransgene00000736
        Construct: WBCnstr00000732
      WBGene00006876 Interactor_type: Trans_regulator
    Variation_interactor: WBVar00088173 Interactor_type: Trans_regulator
  Interaction_summary: "In Myotactin (let-805) mutants, VAB-19::GFP was normally localized to muscle-adjacent regions of the epidermis but never became distributed into circumferential stripes. Within 15-20 minutes of muscle contraction starting (~430 minutes), VAB-19::GFP became dispersed into puncta within epidermal cells (Fig. 6B). Thus, VAB-19 requires Myotactin for its subcellular localization in epidermal cells. By contrast, in vab-10A(ju281ts) mutants, VAB-19::GFP remained confined to the regions of epidermal cells overlying muscle (Fig. 6D) but never became localized to attachment structures."
  Detection_method: Construct
    Reporter_gene: [VAB-19::GFP]
    Transgene
  Regulation_level: Post_translational
  Regulation_result: Positive_regulate: Life_stage: WBls:0000003
      Anatomy_term: WBbt:0005733
      Subcellular_localization: attachment structures
  Paper: WBPaper00006290
  Remark: Fig. 6d