WormBase Tree Display for Gene: WBGene00006882
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| WBGene00006882 | SMap | S_parent | Sequence | T22D2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | vab-19 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T22D2.1 | ||||||||
| Molecular_name | T22D2.1 | ||||||||
| T22D2.1.1 | |||||||||
| CE34375 | |||||||||
| Other_name | T22D2.a | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_T22D2.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | vab-19 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vab | ||||||||
| Allele (208) | |||||||||
| Legacy_information | Variable abnormal morphology | ||||||||
| Strain | WBStrain00005381 | ||||||||
| WBStrain00005348 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (47) | |||||||||
| Structured_description | Concise_description | vab-19 encodes an ankyrin repeat-containing protein that is a member of a conserved family of proteins that includes human Kank, a predicted tumor suppressor; during embryonic morphogenesis, vab-19 activity is essential for epidermal elongation and proper attachment of muscle to the epidermis, specifically the localization of attachment structures to muscle-adjacent regions of epidermal cells and normal epidermal actin organization; a VAB-19::GFP fusion protein is expressed in dorsal and ventral epidermal cells where it organizes into circumferential bands and colocalizes with components of epidermal attachment structures; VAB-19::GFP is also detected in mechanosensory neuronal processes; recruitment of VAB-19 to epidermal attachment structures requires activity of VAB-10/Spectraplakin, while VAB-19 and LET-805/Myotactin are mutually required for localization into circumferential stripes. | Paper_evidence | WBPaper00006290 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 28 Feb 2007 00:00:00 | ||||||||
| Automated_description | Involved in several processes, including actin cytoskeleton organization; cell-cell junction maintenance; and embryo development. Located in cell-cell junction; hemidesmosome; and intermediate filament. Expressed in hypodermis; marginal cell; uterus; and vulD. Used to study cancer. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16; renal cell carcinoma; and spastic quadriplegic cerebral palsy 2. Is an ortholog of human KANK2 (KN motif and ankyrin repeat domains 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00038447 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Oct 2022 00:00:00 | ||||||||
| Potential_model | DOID:0081360 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19309) | |||||
| DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19309) | ||||||
| DOID:0080272 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29300) | ||||||
| Models_disease_asserted | WBDOannot00001340 | ||||||||
| Molecular_info | Corresponding_CDS | T22D2.1 | |||||||
| Corresponding_CDS_history | T22D2.1:wp102 | ||||||||
| Corresponding_transcript | T22D2.1.1 | ||||||||
| Other_sequence (27) | |||||||||
| Associated_feature (20) | |||||||||
| Experimental_info | RNAi_result (28) | ||||||||
| Expr_pattern | Expr2823 | ||||||||
| Expr9306 | |||||||||
| Expr1013608 | |||||||||
| Expr1032918 | |||||||||
| Expr1157382 | |||||||||
| Expr2017947 | |||||||||
| Expr2036083 | |||||||||
| Drives_construct | WBCnstr00000732 | ||||||||
| WBCnstr00000733 | |||||||||
| WBCnstr00000734 | |||||||||
| WBCnstr00000735 | |||||||||
| WBCnstr00000736 | |||||||||
| WBCnstr00005432 | |||||||||
| WBCnstr00008709 | |||||||||
| WBCnstr00008710 | |||||||||
| WBCnstr00008756 | |||||||||
| Construct_product | WBCnstr00008709 | ||||||||
| WBCnstr00008756 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (127) | |||||||||
| Interaction (38) | |||||||||
| Anatomy_function | WBbtf0453 | ||||||||
| WBbtf0454 | |||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| Map_info | Map | II | Position | -13.8053 | Error | 0.066585 | |||
| Positive | Inside_rearr | nDf2 | |||||||
| nDf3 | |||||||||
| Positive_clone | T22D2 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 7112 | |||||||
| 7113 | |||||||||
| 7115 | |||||||||
| 7117 | |||||||||
| Multi_point | 3907 | ||||||||
| 5452 | |||||||||
| 3908 | |||||||||
| Pos_neg_data | 10542 | ||||||||
| 10543 | |||||||||
| Reference (23) | |||||||||
| Method | Gene |
