WormBase Tree Display for Interaction: WBInteraction000543612

WBInteraction000543612 Interaction_type: Regulatory: Change_of_expression_level
  Interactor: Interactor_overlapping_gene: WBGene00004809 Interactor_type: Trans_regulated
      WBGene00004810 Interactor_type: Trans_regulated
      WBGene00004811 Interactor_type: Trans_regulated
      WBGene00000841 Interactor_type: Trans_regulated
    Molecule_interactor: WBMol:00005300 Interactor_type: Trans_regulator
  Interaction_summary: "To perturb UPS function pharmacologically, we used the proteasome inhibitor MG-132 and similarly saw that this led to dramatic increase in C17H1.6 and F26F2.1 expression (Figure S8A-C). Because C17H1.6 and F26F2.1 are genes of unknown function, we extended these analyses to genes upregulated by intracellular infection that have predicted function, namely the genes that encode the SCF ubiquitin ligase components skr-3, skr-4, skr-5 and cul-6 (Figure 6C, Figure S8C). Similar to other infection response genes, we found that these genes were also induced by RNAi against the UPS, while another SCF component, skr-1, whose expression was not altered during microsporidia infection, was not affected (Figure 6C, Figure S8C)."
  Detection_method: RT_PCR
  Regulation_level: Transcriptional
  Paper: WBPaper00045401
  Remark: Fig. 6c, Fig. S8