WormBase Tree Display for Gene: WBGene00023416

WBGene00023416 SMap: S_parent: Sequence: R10H1
  Identity: Version: 3
    Name: CGC_name: spi-1 Paper_evidence: WBPaper00029343
          Person_evidence: WBPerson390
      Sequence_name: R10H1.4
      Molecular_name: R10H1.4
        R10H1.4.1
        CE31821
        R10H1.4.2
      Other_name: isl-1
        CELE_R10H1.4 Accession_evidence: NDB BX284602
      Public_name: spi-1
    DB_info: Database: AceView gene 2H785
        WormQTL gene WBGene00023416
        WormFlux gene WBGene00023416
        NDB locus_tag CELE_R10H1.4
        NCBI gene 174219
        RefSeq protein NM_182250.4
        SwissProt UniProtAcc Q8MPZ7
        UniProt_GCRP UniProtAcc Q8MPZ7
    Species: Caenorhabditis elegans
    History: Version_change: 1 02 Jul 2004 16:55:44 WBPerson1971 Event: Created
        2 15 Nov 2004 13:56:33 WBPerson2970 Event: Acquires_merge: WBGene00020001
        3 04 Mar 2014 10:56:22 WBPerson2970 Name_change: CGC_name: spi-1
                Other_name: isl-1
      Acquires_merge: WBGene00020001
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: spi
    Allele (27)
    Strain: WBStrain00032690
    RNASeq_FPKM (74)
    GO_annotation: 00084456
      00084457
      00084458
      00084459
    Ortholog (25)
    Structured_description: Concise_description: isl-1 encodes a putative secreted TIL-domain protease inhibitorparalogous to SWM-1 and the products of 13 other C. elegans genes; ISL-1and its relatives are collectively similar to other TIL-domain proteaseinhibitors from nematodes, insects, and vertebrates, such as Ascarissuum trypsin inhibitor ATI and Onchocerca volvulus SPI-1. Paper_evidence: WBPaper00027081
            WBPaper00029338
            WBPaper00029339
            WBPaper00029340
            WBPaper00029341
            WBPaper00029342
            WBPaper00029343
          Curator_confirmed: WBPerson567
          Date_last_updated: 09 May 2007 00:00:00
      Automated_description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: R10H1.4
    Corresponding_transcript: R10H1.4.1
      R10H1.4.2
    Other_sequence: CJC14454_1
      Dviv_isotig35784
    Associated_feature: WBsf657203
  Experimental_info: RNAi_result: WBRNAi00051734 Inferred_automatically: RNAi_primary
      WBRNAi00051735 Inferred_automatically: RNAi_primary
      WBRNAi00034833 Inferred_automatically: RNAi_primary
      WBRNAi00017725 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1019518
      Expr1040130
      Expr1155401
      Expr2016056
      Expr2034291
    Drives_construct: WBCnstr00037817
    Construct_product: WBCnstr00037817
    Microarray_results (17)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00037946:MAB-5_interacting
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00042477:prp-8(RNAi)_downregulated_RNAseq
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00043945:MeHg_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00044786:emr-1(gk119)_upregulated
      WBPaper00044786:lem-2(tm1582)_upregulated
      WBPaper00045257:bar-1(ga80)_downregulated
      WBPaper00045390:ubc-9(RNAi)_upregulated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00048611:MnCl2_upregulated
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00054410:set-9(rw5)_downregulated
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056169:rrf-3(pk1426)_upregulated_L2
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056617:adr-1_upregulated_L4_transcript
      WBPaper00056826:SGP_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060273:vrk-1(RNAi)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060445:ikb-1(nr2027)_downregulated_L4
      WBPaper00060445:nfki-1(cer1)_downregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_downregulated_L4
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061340:AMso
      WBPaper00061340:Anterior_arcade_cell
      WBPaper00061340:B
      WBPaper00061340:CEPso
      WBPaper00061340:Excretory_duct_and_pore
      WBPaper00061340:F_U
      WBPaper00061340:Glia
      WBPaper00061340:hyp1V_and_ant_arc_V
      WBPaper00061340:hyp1_hyp2
      WBPaper00061340:hyp3
      WBPaper00061340:K_Kprime
      WBPaper00061340:M4_parent
      WBPaper00061340:mc1
      WBPaper00061340:Neuroblast_I6_M5
      WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V
      WBPaper00061340:Parent_of_MI_pm1DR
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061340:pm3_pm4_pm5
      WBPaper00061340:RME_LR_parent
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061527:F54D5.3_7003-F54D5.3_7004
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061651:AMso_enriched
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064532:pals-25(icb98)_downregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065225:nhr-42(tm1375)_upregulated_uninfected
      WBPaper00065392:P.pentosaceus_downregulated
      WBPaper00065841:79_2
      WBPaper00065841:82_1
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_1_3
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00034739:N2lessDR1350
      WBPaper00034739:RIL17lessRIL14
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00036286:Pattern_G
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00041002:HQ_3d_0.2mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041609:hpl-1_hpl-2_upregulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00045015:nhr-25(RNAi)_upregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00046548:dafachronic-acid_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00050538:Fasting_upregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc6390]:Cluster_A
  Map_info: Map: II Position: 0.503423 Error: 2.5e-05
    Positive: Positive_clone: R10H1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00014293
    WBPaper00056840
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene