WormBase Tree Display for Gene: WBGene00022856
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| WBGene00022856 | SMap | S_parent | Sequence | ZK1127 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cth-2 | Person_evidence | WBPerson1711 | |||||
| Sequence_name | ZK1127.10 | ||||||||
| Molecular_name | ZK1127.10 | ||||||||
| ZK1127.10.1 | |||||||||
| CE07648 | |||||||||
| Other_name | CELE_ZK1127.10 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | cth-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:06 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 10 Sep 2008 16:37:04 | WBPerson2970 | Name_change | CGC_name | cth-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cth | ||||||||
| Allele (15) | |||||||||
| Strain | WBStrain00007972 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00007533 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00009048 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cth-2 encodes a putative cystathionine gamma-lyase; CTH-2 is orthologous to human CTH (OMIM:607657, mutated in cystathioninuria), extremely similar to its paralog CTH-1, and also paralogous to CBL-1; either CTH-2, or CTH-1, or both proteins weakly inhibitDHC-1 in vivo; CTH-2 is expressed in both larval and adult hypodermis, anal depressor muscle, and body wall muscle, as well as in adult vulval muscle and reproductive system; CTH-2 binds SMN-1 in yeast two-hybrid assays. | Paper_evidence | WBPaper00006525 | |||||
| WBPaper00028478 | |||||||||
| WBPaper00030897 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 15 Sep 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in cysteine biosynthetic process via cystathionine and transsulfuration. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in cystathioninuria. Is an ortholog of human CTH (cystathionine gamma-lyase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9252 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2501) | ||||
| DOID:0090142 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2501) | ||||||
| Molecular_info | Corresponding_CDS | ZK1127.10 | |||||||
| Corresponding_transcript | ZK1127.10.1 | ||||||||
| Other_sequence (100) | |||||||||
| Associated_feature | WBsf650204 | ||||||||
| WBsf655366 | |||||||||
| WBsf655367 | |||||||||
| WBsf665670 | |||||||||
| WBsf988344 | |||||||||
| WBsf1012482 | |||||||||
| WBsf223280 | |||||||||
| WBsf223281 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Chronogram527 | ||||||||
| Expr7188 | |||||||||
| Expr9561 | |||||||||
| Expr1017288 | |||||||||
| Expr1040112 | |||||||||
| Expr1162551 | |||||||||
| Expr2010574 | |||||||||
| Expr2028814 | |||||||||
| Drives_construct | WBCnstr00002589 | ||||||||
| WBCnstr00023917 | |||||||||
| WBCnstr00040868 | |||||||||
| Construct_product | WBCnstr00014126 | ||||||||
| WBCnstr00023917 | |||||||||
| WBCnstr00040868 | |||||||||
| WBCnstr00040869 | |||||||||
| WBCnstr00040870 | |||||||||
| WBCnstr00040871 | |||||||||
| WBCnstr00040872 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (250) | |||||||||
| Interaction (91) | |||||||||
| Map_info | Map | II | Position | 0.361481 | Error | 0.004775 | |||
| Positive | Positive_clone | ZK1127 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
