WormBase Tree Display for Gene: WBGene00021311

WBGene00021311 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 2
    Name: CGC_name: thoc-5 Person_evidence: WBPerson1521
      Sequence_name: Y32H12A.2
      Molecular_name: Y32H12A.2a
        Y32H12A.2a.1
        CE43676
        Y32H12A.2b
        CE43711
        Y32H12A.2b.1
      Other_name: CELE_Y32H12A.2 Accession_evidence: NDB BX284603
      Public_name: thoc-5
    DB_info: Database: AceView gene 3G436
        WormQTL gene WBGene00021311
        WormFlux gene WBGene00021311
        NDB locus_tag CELE_Y32H12A.2
        Panther gene CAEEL|WormBase=WBGene00021311|UniProtKB=C2BR94
          family PTHR13375
        NCBI gene 175735
        RefSeq protein NM_001267997.3
            NM_001267998.4
        TREEFAM TREEFAM_ID TF314812
        TrEMBL UniProtAcc H2L0N5
            C2BR94
        UniProt_GCRP UniProtAcc C2BR94
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:04 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 02 May 2017 10:45:03 WBPerson2970 Name_change: CGC_name: thoc-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: thoc
    Allele (41)
    RNASeq_FPKM (74)
    GO_annotation: 00006811
      00006812
      00006813
      00006814
      00006815
      00006816
      00006817
    Contained_in_operon: CEOP3292
    Ortholog (33)
    Structured_description: Concise_description: Y32H12A.2 encodes the C. elegans ortholog of mammalian THOC5, a subunit of the THO complex involved in mRNP biogenesis as part of transcription elongation, mRNA maturation, and export. Paper_evidence: WBPaper00041879
          Curator_confirmed: WBPerson1843
          Date_last_updated: 09 Jan 2013 00:00:00
      Automated_description: Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus and positive regulation of DNA-templated transcription, elongation. Predicted to be located in nucleus. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in breast carcinoma. Is an ortholog of human THOC5 (THO complex subunit 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3459 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:19074)
  Molecular_info: Corresponding_CDS: Y32H12A.2a
      Y32H12A.2b
    Corresponding_CDS_history: Y32H12A.2:wp202
    Corresponding_transcript: Y32H12A.2a.1
      Y32H12A.2b.1
    Other_sequence (23)
    Associated_feature: WBsf651042
      WBsf666901
      WBsf226663
      WBsf226664
      WBsf226665
      WBsf226666
  Experimental_info: RNAi_result (13)
    Expr_pattern: Expr13875
      Expr1019175
      Expr1039290
      Expr1159336
      Expr2017392
      Expr2035531
    Drives_construct: WBCnstr00024587
    Construct_product: WBCnstr00024587
      WBCnstr00040172
    Regulate_expr_cluster: WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055103:thoc-5(wy822)_upregulated
    Microarray_results (29)
    Expression_cluster: WBPaper00028451:Low_abundance_spermatogenesis_enriched
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045420:fertilization_downregulated_protein
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055648:germline_expressed
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00059194:KLF-1_interacting
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:RID_parent
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
      WBPaper00061527:dpy-26-B0205.1
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064505:tamoxifen_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_6_3
      cgc4489_group_2
      WBPaper00025032:cluster_38
      WBPaper00025032:cluster_172
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00035873:dpy-9_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037695:CC_3-day
      WBPaper00038060:SUMO-1_upregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_3
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(66_min)
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_E_pi(186_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:Cluster_E
      [cgc6390]:intrinsic
    Interaction (16)
  Map_info: Map: III Position: -1.80654
    Positive: Positive_clone: Y32H12A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00037145
    WBPaper00038491
    WBPaper00041069
    WBPaper00041879
    WBPaper00052341
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene