WormBase Tree Display for Gene: WBGene00021070

WBGene00021070 SMap: S_parent: Sequence: W07B8
  Identity: Version: 2
    Name: CGC_name: cpr-8
      Sequence_name: W07B8.1
      Molecular_name: W07B8.1a
        W07B8.1a.1
        CE14674
        W07B8.1b
      Other_name: drd-3 Paper_evidence: WBPaper00044557
          Person_evidence: WBPerson10050
        CELE_W07B8.1 Accession_evidence: NDB BX284605
      Public_name: cpr-8
    DB_info: Database: AceView gene 5B617
        WormQTL gene WBGene00021070
        WormFlux gene WBGene00021070
        NDB locus_tag CELE_W07B8.1
        Panther gene CAEEL|WormBase=WBGene00021070|UniProtKB=O16289
          family PTHR12411
        NCBI gene 178613
        RefSeq protein NM_070983.7
            NR_132498.1
        TrEMBL UniProtAcc O16289
        UniProt_GCRP UniProtAcc O16289
        RNAcentral URSid URS0000843C85
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:04 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 29 Apr 2015 12:07:40 WBPerson2970 Name_change: CGC_name: cpr-8
                Other_name: drd-3
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cpr
    Allele (84)
    Strain: WBStrain00032862
    RNASeq_FPKM (74)
    GO_annotation: 00027684
      00027685
      00027686
      00125538
      00125539
    Ortholog (39)
    Paralog (28)
    Structured_description: Automated_description: Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of the nervous system (multiple); carcinoma (multiple); and type 2 diabetes mellitus. Is an ortholog of human CTSB (cathepsin B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9351 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2527)
      DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2527)
      DOID:2671 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2527)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2527)
      DOID:2377 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2527)
      DOID:10941 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2527)
      DOID:12842 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2527)
      DOID:3068 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2527)
      DOID:4914 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2527)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2527)
  Molecular_info: Corresponding_CDS: W07B8.1a
    Corresponding_transcript: W07B8.1b
      W07B8.1a.1
    Associated_feature: WBsf999258
      WBsf999259
      WBsf1019135
      WBsf1019136
      WBsf231385
  Experimental_info: RNAi_result: WBRNAi00115176 Inferred_automatically: RNAi_primary
      WBRNAi00089178 Inferred_automatically: RNAi_primary
      WBRNAi00076746 Inferred_automatically: RNAi_primary
      WBRNAi00019692 Inferred_automatically: RNAi_primary
      WBRNAi00036358 Inferred_automatically: RNAi_primary
      WBRNAi00054940 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1014103
      Expr1158475
      Expr2010508
      Expr2028748
    Microarray_results (19)
    Expression_cluster: WBPaper00032479:CB4856vsN2_LifeStageProfile_Variation
      WBPaper00036738:4uM_Heme_upregulated
      WBPaper00036738:500uM_Heme_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00040412:germline-regulated_daf-16_target
      WBPaper00042215:wdr-23(tm1817)_downregulated
      WBPaper00042561:smg-2(RNAi)_downregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044260:nicotinc-acid_upregulated
      WBPaper00044557:DietaryRestriction_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045390:ubc-9(RNAi)_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00047131:daf-2(e1370)_downregulated_N2-background
      WBPaper00048923:Aging_regulated
      WBPaper00048952:glucose_induced
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049134:hpk-1(pk1393)_downregulated
      WBPaper00049217:TCER-1_upregulated
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050193:cec-4(ok3124)_downregulated_L1
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050801:SET-4_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051265:F4_hrde-1(tm1200)_downregulated
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053814:15C_upregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00054796:cav-1(RNAi)_upregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055944:C.butyricum_vs_OP50_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056169:rrf-3(pk1426)_upregulated_adult
      WBPaper00056169:rrf-3(pk1426)_upregulated_L3
      WBPaper00056169:rrf-3(pk1426)_upregulated_L4
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:flcn-1(ok975)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057196:raga-1(ok386)_downregulated)
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00059253:sucrose_stearic-acid_upregulated
      WBPaper00059253:sucrose_upregulated
      WBPaper00059373:stt-3(RNAi)_downregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059895:wounding_downregulated
      WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060661:hypoxia_upregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060764:swsn-1(os22ts)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:HB115_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061340:ALN
      WBPaper00061340:RIH
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061424:Diet_MYb120_downregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:W07B8.1-C15C8.3
      WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_downregulated
      WBPaper00061823:mex-3(spr9)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062590:Aging_downregulated_body-wall-muscle
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065158:25C_vs_15C_downregulated_AFD
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065392:Lb.delbrueckii_upregulated
      WBPaper00065392:Lb.gasseri_upregulated
      WBPaper00065392:Lb.plantarum_upregulated
      WBPaper00065392:Lb.reuteri_upregulated
      WBPaper00065392:Lb.rhamnosus_upregulated
      WBPaper00065392:P.pentosaceus_upregulated
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066038:mip-1(how5)_downregulated
      cgc4489_group_7
      WBPaper00025099:MA_specific
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00029437:dcr-1_downregulated
      WBPaper00030985:Erwinia_carotovora_upregulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031703:heme_responsive_1
      WBPaper00032165:differentially_expressed_with_age_medoid_4
      WBPaper00032948:FedUp
      WBPaper00035479:daf-16(RNAi)_upregulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036286:Pattern_G
      WBPaper00037695:WC_5-day
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038231:Cry5B_2-fold_downregulated
      WBPaper00039866:ClassComp_daf-19_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
      WBPaper00040210:Chlorpyrifos_16C_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041906:I-3690_vs_OP50_10d
      WBPaper00041906:I-4317_vs_OP50_10d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00044535:male_downregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
      WBPaper00053550:daf-19(m86)_downregulated_L1
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc6390]:Cluster_C
    Interaction: WBInteraction000108869
      WBInteraction000227593
      WBInteraction000292392
      WBInteraction000382485
      WBInteraction000455274
      WBInteraction000459558
      WBInteraction000503272
  Map_info: Map: V Position: -19.8519
    Positive: Positive_clone: W07B8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00044557
    WBPaper00055090
    WBPaper00059755
    WBPaper00061178
    WBPaper00064130
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene