| WBGene00020891 | SMap | S_parent | Sequence | T28C12 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | cest-24 | Person_evidence | WBPerson36909 |
| | | | | | WBPerson7188 |
| | | Sequence_name | T28C12.4 |
| | | Molecular_name | T28C12.4a |
| | | | T28C12.4a.1 |
| | | | CE14343 |
| | | | T28C12.4b |
| | | | CE14345 |
| | | | T28C12.4a.2 |
| | | | T28C12.4b.1 |
| | | | T28C12.4b.2 |
| | | Other_name | CELE_T28C12.4 | Accession_evidence | NDB | BX284605 |
| | | Public_name | cest-24 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:31:03 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 20 May 2019 14:10:26 | WBPerson1983 | Name_change | CGC_name | cest-24 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cest |
| | Allele (128) |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00028487 |
| | | 00028488 |
| | | 00028489 |
| | | 00028490 |
| | Ortholog (36) |
| | Paralog (41) |
| | Structured_description | Concise_description | T28C12.4 encodes a protein with visible similarity to human neuroligin 4 (mutated in autism), but also belongs to a large family of carboxylesterases that happen to include NLG-1; normally, T28C12.4 is expressed in hypodermal cells; transcription of T28C12.4 is immediately induced by exposure to ethanol, and with glr-2 is one of a few genes that may be specifically responsive to ethanol (as opposed to other stresses, which are expected to typically induce heat shock genes); the 5' flank of T28C12.4 contains a single ethanol- and stress-responsive element that is required in a T28C12.4::GFP transgene for transcriptional induction by ethanol. | Paper_evidence | WBPaper00006465 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 11 Feb 2007 00:00:00 |
| | | Automated_description | Predicted to enable carboxylic ester hydrolase activity. Expressed in hypodermis and seam cell. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Disease_relevance | Human liver carboxylesterases, CES1, CES2 and CES3 (orthologous to C. elegans T28C12.4), metabolize and detoxify drugs and toxins; CESs metabolize ester, thioester, carbamate and amide compounds to acid, alcohol and amine products; mutations in CES1 are associated with Carboxylesterase 1 deficiency. | Homo sapiens | Accession_evidence | OMIM | 114835 |
| | | | | | | 605278 |
| | | | | | | 605279 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 26 Jun 2012 00:00:00 |
| Molecular_info | Corresponding_CDS | T28C12.4a |
| | | T28C12.4b |
| | Corresponding_transcript | T28C12.4a.1 |
| | | T28C12.4a.2 |
| | | T28C12.4b.1 |
| | | T28C12.4b.2 |
| | Other_sequence (41) |
| | Associated_feature | WBsf646872 |
| | | WBsf646873 |
| | | WBsf661326 |
| | | WBsf661327 |
| | | WBsf661328 |
| | | WBsf661329 |
| | | WBsf1000225 |
| | | WBsf1000226 |
| | | WBsf231867 |
| | | WBsf231868 |
| Experimental_info | RNAi_result | WBRNAi00054391 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00019384 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089171 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00036074 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr2907 |
| | | Expr1019072 |
| | | Expr1039101 |
| | | Expr1157938 |
| | | Expr2006605 |
| | | Expr2024821 |
| | Drives_construct | WBCnstr00011018 |
| | | WBCnstr00024806 |
| | Construct_product | WBCnstr00024806 |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:germline-precursors_embryo_enriched |
| | | WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_larva_enriched |
| | | WBPaper00037950:hypodermis_larva_SelectivelyEnriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042165:let-7_upregulated |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044260:1-methylnicotinamide_upregulated |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00044743:wdr-23_neuron_upregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049217:TCER-1_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(+) |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050903:mir-35-41(nDf50)_25C_upregulated |
| | | WBPaper00050990:hypodermis_enriched |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051021:4-bromodiphenyl-ether_upregulated |
| | | WBPaper00051388:Glucose-diet_upregulated |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_upregulated |
| | | WBPaper00053814:15C_downregulated_PY79 |
| | | WBPaper00054872:egl-9(sa307)_upregulated |
| | | WBPaper00055013:hmg-3(bar24)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_downregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055941:nuo-6(qm200)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056039:efa-6(tm3124)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057068:Cadmium_upregulated |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058958:10mGy-irradiation-72h_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_downregulated |
| | | WBPaper00059224:tph-1(mg280)_upregulated |
| | | WBPaper00059253:stearic-acid_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059598:HeatShock_upregulated |
| | | WBPaper00059604:fluvastatin_downregulated_N2 |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059735:glucose_upregulated_lpin-1(RNAi) |
| | | WBPaper00059735:glucose_upregulated_N2 |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_OP50 |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060278:atp-2(RNAi)_upregulated |
| | | WBPaper00060434:pH4.33_vs_pH6.33_downrgulated |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L1 |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060526:plp-1(ok2155)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(overexpression)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:hyp4_hyp5_hyp6 |
| | | WBPaper00061340:hyp7_AB_lineage |
| | | WBPaper00061340:hyp7_C_lineage |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:C25E10.12-F17H10.2 |
| | | WBPaper00061590:CGP37157_upregulated |
| | | WBPaper00061651:AMso_enriched |
| | | WBPaper00061651:CEP_enriched |
| | | WBPaper00061651:PHso_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:daf-16(RNAi)_downregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_upregulated_N2 |
| | | WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13) |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062354:H.zoospora_12h_regulated |
| | | WBPaper00062440:crh-1(n3315)_upregulated |
| | | WBPaper00062440:crh-1(syb385)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064762:freezing-thaw_regulated |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00064999:miR-229-64-65-66_downregulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C |
| | | WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal |
| | | WBPaper00065225:nhr-42(tm1375)_downregulated_S.aureus-infected |
| | | WBPaper00065749:Heat-Shock_upregulated_N2 |
| | | WBPaper00065841:0_0 |
| | | WBPaper00065841:21_1 |
| | | WBPaper00065841:30_1 |
| | | WBPaper00065841:30_2 |
| | | WBPaper00065841:33_0 |
| | | WBPaper00065841:33_1 |
| | | WBPaper00065841:64_0 |
| | | WBPaper00065841:79_0 |
| | | WBPaper00065841:79_2 |
| | | WBPaper00065877:rege-1(imm070)_upregulated_PA14 |
| | | WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4489_group_25 |
| | | WBPaper00006465:I_ethanol_rapid_induction |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030985:Photorhabdus_luminescens_upregulated |
| | | WBPaper00030985:Serratia_marcesens_upregulated |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00032948:FedUp |
| | | WBPaper00034661:AgNPs_upregulated |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035084:L2_enriched_AIN-2_IP |
| | | WBPaper00035084:L3_enriched_AIN-2_IP |
| | | WBPaper00035084:L4_enriched_AIN-2_IP |
| | | WBPaper00035560:ahr-1_downregulated |
| | | WBPaper00035873:osmotically_regulated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00038172:crh-1null_up_regulated |
| | | WBPaper00038172:tax-6null_up_regulated |
| | | WBPaper00039792:TempShiftDecrease |
| | | WBPaper00040210:Chlorpyrifos_16C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HF_11d_0.2mM_Up |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041211:RPW-24_Up |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042067:Cu2+_upregulated_WT |
| | | WBPaper00042234:xpa-1_upregulated |
| | | WBPaper00042236:flcn-1(ok975)_upregulated |
| | | WBPaper00044091:Bpseudomallei_induced_2h |
| | | WBPaper00044091:Bpseudomallei_induced_8h |
| | | WBPaper00044091:Bpseudomallei_induced_12h |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00046548:dafachronic-acid_downregulated |
| | | WBPaper00047021:MWCNT_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00047070:N2_UV_upregulated |
| | | WBPaper00047070:xpa-1_UV_upregulated |
| | | WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00053827:pyoverdine_upregulated |
| | | WBPaper00055899:2,4-Dinitroanisole_regulated |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | WBPaper00057098:SiO2-nanoparticles_downregulated |
| | Interaction (33) |
| Map_info | Map | V | Position | -0.18384 |
| | Positive | Positive_clone | T28C12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00006465 |
| | WBPaper00010030 |
| | WBPaper00016665 |
| | WBPaper00032322 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
