WormBase Tree Display for Gene: WBGene00020887

WBGene00020887 SMap: S_parent: Sequence: T28B4
  Identity: Version: 2
    Name: CGC_name: hic-1 Person_evidence: WBPerson3235
      Sequence_name: T28B4.4
      Molecular_name: T28B4.4
        T28B4.4.1
        CE33711
        T28B4.4.2
      Other_name: CELE_T28B4.4 Accession_evidence: NDB BX284606
      Public_name: hic-1
    DB_info: Database: AceView gene XH216
        WormQTL gene WBGene00020887
        WormFlux gene WBGene00020887
        NDB locus_tag CELE_T28B4.4
        NCBI gene 189029
        RefSeq protein NM_076710.8
        TREEFAM TREEFAM_ID TF317021
        TrEMBL UniProtAcc O17346
        UniProt_GCRP UniProtAcc O17346
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:03 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 11 Oct 2017 16:33:09 WBPerson1983 Name_change: CGC_name: hic-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hic
    Allele (16)
    Strain: WBStrain00033187
    RNASeq_FPKM (74)
    GO_annotation: 00029648
    Ortholog (21)
    Paralog: WBGene00044574 Caenorhabditis elegans From_analysis: TreeFam
    Structured_description: Concise_description: T28B4.4 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; T28B4.4 is worm-specific, weakly similar to CLC-1; T28B4.4 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water. Paper_evidence: WBPaper00004961
            WBPaper00005654
            WBPaper00005946
            WBPaper00005975
            WBPaper00012856
            WBPaper00018356
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to be located in membrane. Expressed in cholinergic neurons; head; tail; and ventral nerve cord. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T28B4.4
    Corresponding_CDS_history: T28B4.4:wp97
    Corresponding_transcript: T28B4.4.1
      T28B4.4.2
    Other_sequence: CJC07086_1
    Associated_feature: WBsf654072
      WBsf1005600
      WBsf1005601
      WBsf1023118
      WBsf237498
      WBsf237499
      WBsf237500
  Experimental_info: RNAi_result: WBRNAi00036070 Inferred_automatically: RNAi_primary
      WBRNAi00054381 Inferred_automatically: RNAi_primary
      WBRNAi00099692 Inferred_automatically: RNAi_primary
      WBRNAi00099288 Inferred_automatically: RNAi_primary
      WBRNAi00019382 Inferred_automatically: RNAi_primary
      WBRNAi00099894 Inferred_automatically: RNAi_primary
      WBRNAi00099490 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr14244
      Expr14245
      Expr1020454
      Expr1157929
      Expr2006598
      Expr2024815
    Drives_construct: WBCnstr00024810
      WBCnstr00040677
      WBCnstr00040678
    Construct_product: WBCnstr00024810
      WBCnstr00040678
    Microarray_results (19)
    Expression_cluster: WBPaper00024505:pharyngeal_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046805:P-granule-RNAi_upregulated_Set1
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_enriched
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00053020:sid-3(ok973)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:nerve-ring_expressed
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056586:kri-1(ok1251)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00057143:ztf-11(RNAi)_upregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059987:Wounding_upregulated
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060764:swsn-9(ok1354)_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061340:AVB
      WBPaper00061340:Pharyngeal_intestinal_valve
      WBPaper00061340:RIM
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:syd-1_2945-unc-41_2170
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061651:AVA_enriched
      WBPaper00061651:AVB_enriched
      WBPaper00061651:Rectal_gland_enriched
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062590:Aging_upregulated_intestine
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064494:postdauer_upregulated_AWA
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
      WBPaper00065158:AFD_enriched
      WBPaper00065331:100nM-ivermectin_upregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065623:64
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:3_4
      WBPaper00065841:26_0
      WBPaper00065841:26_2
      WBPaper00065841:30_0
      WBPaper00065841:30_4
      WBPaper00065841:61_0
      WBPaper00065841:86_0
      WBPaper00065841:109_0
      WBPaper00065841:118_0
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_transcript
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066204:CdCl2_upregulated_mRNA
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4489_group_14
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026980:intestine_enriched
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00032948:FedUp
      WBPaper00035227:heat_shock_regulated
      WBPaper00036383:ash-2_Day8_regulated
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040876:mir-35_downregulated
      WBPaper00040963:TA300_up
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00044091:Bpseudomallei_induced_4h
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00045015:nhr-25(RNAi)_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
    Interaction: WBInteraction000220885
      WBInteraction000262568
      WBInteraction000288199
      WBInteraction000383031
      WBInteraction000426567
      WBInteraction000559801
  Map_info: Map: X Position: -2.74936
    Positive: Positive_clone: T28B4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00055660
    WBPaper00065331
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene