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WormBase Tree Display for Gene: WBGene00020867

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Name Class

WBGene00020867SMapS_parentSequenceT27F7
IdentityVersion2
NameCGC_nameshc-2Paper_evidenceWBPaper00004558
Person_evidenceWBPerson842
WBPerson50
Sequence_nameT27F7.2
Molecular_name (11)
Other_nameCELE_T27F7.2Accession_evidenceNDBBX284602
Public_nameshc-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:03WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
218 Oct 2006 16:47:14WBPerson2970Name_changeCGC_nameshc-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classshc
Allele (275)
RNASeq_FPKM (74)
Ortholog (32)
ParalogWBGene00006508Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionT27F7.2 encodes three proteins by multiple splicing, two of which (T27F7.2A-B) are fully orthologous to vertebrate Shc proteins (e.g., p52/p46SHC and p66SHC); like their orthologs, T27F7.2A-B have a PTB and an SH2 domain in N- to C-terminal order; T27F7.2 is expressed in gastrulating embryos (probably in neural precursors); T27F7.2 might be involved in RAS signal transduction or regulation of apoptosis.Paper_evidenceWBPaper00004558
WBPaper00004651
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnriched in several structures, including ABalpapaap; excretory gland cell; g1; neurons; and somatic gonad precursor based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-2; hsf-1; and sir-2.1 based on RNA-seq and microarray studies. Is affected by eleven chemicals including 1-methylnicotinamide; Zidovudine; and Psoralens based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: SH2 domain superfamily and SH2 domain. Is an ortholog of human SH2D5 (SH2 domain containing 5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDST27F7.2a
T27F7.2b
T27F7.2c
Corresponding_CDS_historyT27F7.2a:wp227
T27F7.2b:wp227
Corresponding_transcriptT27F7.2a.1
T27F7.2b.1
T27F7.2b.2
T27F7.2c.1
T27F7.2c.2
Other_sequence (18)
Associated_feature (31)
Experimental_infoRNAi_resultWBRNAi00054347Inferred_automaticallyRNAi_primary
WBRNAi00054348Inferred_automaticallyRNAi_primary
WBRNAi00036052Inferred_automaticallyRNAi_primary
Expr_patternExpr417
Expr1011838
Expr1039096
Expr1157894
Expr2015807
Expr2034040
Microarray_results (34)
Expression_clusterWBPaper00031040:Cluster_6
WBPaper00032031:DConiospora_upregulated_OligoArray_24h
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:dopaminergic-neurons_larva_enriched
WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
WBPaper00037950:hypodermis_larva_enriched
WBPaper00037950:hypodermis_larva_SelectivelyEnriched
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00040731:Static_Magnetic_Field_upregulated
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:flat_dev_expression
WBPaper00045521:Spermatogenic
WBPaper00045571:germline-ablation_upregulated
WBPaper00046121:mesoderm_unique
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
WBPaper00046805:csr-1(RNAi)_upregulated_Set1
WBPaper00048988:neuron_expressed
WBPaper00049018:ham-3(RNAi)_upregulated
WBPaper00049018:swsn-2.2(RNAi)_upregulated
WBPaper00049098:heat-induced_hrde-1(tm1200)
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049626:UNC-75_target
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050053:muscle_enriched_Day4
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051311:VGLN-1-interacting
WBPaper00051352:Long-Term-Association-Memory_upregulated
WBPaper00051404:alg-1(gk214)_downregulated
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster3
WBPaper00053599:female_vs_male_downregulated
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056161:male_enriched_siRNA
WBPaper00056443:DietaryRestriction_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056809:smn-1(ok355)_upregulated
WBPaper00056826:SGP_biased
WBPaper00056855:his-72(uge40)_upregulated
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059224:tph-1(mg280)_upregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059763:neuron_expressed
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00060014:set-2(zr2012)_downregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:ADA_ADE_grandparent
WBPaper00061340:AIM
WBPaper00061340:AVJ
WBPaper00061340:CAN
WBPaper00061340:Ciliated_non_amphid_neuron
WBPaper00061340:DVC_parent
WBPaper00061340:Excretory_cell_parent
WBPaper00061340:Excretory_gland
WBPaper00061340:g1A_g1P
WBPaper00061340:g1A_parent
WBPaper00061340:I2_grandparent
WBPaper00061340:M4_parent
WBPaper00061340:Neuroblast_AIZ_FLP_RMG
WBPaper00061340:Neuroblast_ALM_BDU
WBPaper00061340:Neuroblast_IL1_IL2
WBPaper00061340:Neuroblast_PVC_LUA
WBPaper00061340:OLQ_grandparent
WBPaper00061340:Parent_of_AMsh_URB
WBPaper00061340:Parent_of_g1P_I3
WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V
WBPaper00061340:Pharyngeal_intestinal_valve
WBPaper00061340:Pharyngeal_neuron
WBPaper00061340:PLM_ALN_great_grandparent
WBPaper00061340:RIA
WBPaper00061340:SIA
WBPaper00061340:URX
WBPaper00061340:Z1_Z4
WBPaper00061527:uggt-1_21889-tag-320_20312
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
WBPaper00064716:paraquat_downregulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065258:anchor-cell_enriched
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065835:mtH2S-AP39-D0-treatment_downregulated_Day11
WBPaper00065841:11_2
WBPaper00065841:36_2
WBPaper00065841:36_3
WBPaper00065841:75_0
WBPaper00065841:100_0
WBPaper00065841:108_0
WBPaper00065841:132_0
WBPaper00066085:sin-3(syb2172)_upregulated
cgc4489_group_21
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00027111:rde-3(ne298)_upregulated
WBPaper00029437:dcr-1_upregulated
WBPaper00030985:Erwinia_carotovora_upregulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031252:AIN-1_IP_enriched
WBPaper00035084:embryo_enriched_AIN-2_IP
WBPaper00040116:pRJ-FR.5_up_regulated
WBPaper00040210:Chlorpyrifos_24C_regulated
WBPaper00040858:eQTL_regulated_old
WBPaper00040963:Q50_down
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:cluster_55
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(53_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
InteractionWBInteraction000304431
WBInteraction000383016
WBInteraction000448874
WBInteraction000543056
Map_infoMapIIPosition-2.60871Error0.002114
PositivePositive_cloneT27F7Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00027580
WBPaper00055090
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene