WormBase Tree Display for Gene: WBGene00020442
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| WBGene00020442 | SMap | S_parent | Sequence | T12A2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gen-1 | Paper_evidence | WBPaper00036708 | |||||
| Person_evidence | WBPerson195 | ||||||||
| Sequence_name | T12A2.8 | ||||||||
| Molecular_name | T12A2.8 | ||||||||
| T12A2.8.1 | |||||||||
| CE01401 | |||||||||
| Other_name | CELE_T12A2.8 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | gen-1 | ||||||||
| DB_info | Database | AceView | gene | 3H336 | |||||
| WormQTL | gene | WBGene00020442 | |||||||
| WormFlux | gene | WBGene00020442 | |||||||
| NDB | locus_tag | CELE_T12A2.8 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00020442|UniProtKB=Q22418 | |||||||
| family | PTHR11081 | ||||||||
| NCBI | gene | 175885 | |||||||
| RefSeq | protein | NM_065960.5 | |||||||
| TREEFAM | TREEFAM_ID | TF101235 | |||||||
| TrEMBL | UniProtAcc | Q22418 | |||||||
| UniProt_GCRP | UniProtAcc | Q22418 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:03 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 03 Aug 2010 10:05:58 | WBPerson2970 | Name_change | CGC_name | gen-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gen | ||||||||
| Allele (42) | |||||||||
| Strain | WBStrain00034666 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Contained_in_operon | CEOP3360 | ||||||||
| Ortholog (22) | |||||||||
| Paralog | WBGene00000794 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00009731 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019004 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | gen-1 encodes the C. elegans homolog of the human GEN1 Holliday Junction resolving enzyme; in C. elegans, GEN-1 activity is required for DNA double-strand break repair and ionizing radiation-induced cell cycle arrest and apoptosis, independent of the CEP-1/p53 pathway, as part of a DNA damage signaling response; GEN-1 exhibits in vitro nuclease activity consistent with it functioning as a junction-resolving enzyme. | Paper_evidence | WBPaper00036708 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Jan 2012 00:00:00 | ||||||||
| Automated_description | Enables crossover junction DNA endonuclease activity. Involved in DNA damage response and negative regulation of nematode larval development. Predicted to be located in cytoplasm and nucleus. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T12A2.8 | |||||||
| Corresponding_transcript | T12A2.8.1 | ||||||||
| Other_sequence | CJC11994_1 | ||||||||
| CRC01733_1 | |||||||||
| Dviv_contig26186 | |||||||||
| Oden_isotig10028 | |||||||||
| Oden_isotig10029 | |||||||||
| CR04857 | |||||||||
| Oden_isotig10027 | |||||||||
| Associated_feature | WBsf651109 | ||||||||
| WBsf651110 | |||||||||
| WBsf976164 | |||||||||
| WBsf976165 | |||||||||
| WBsf992691 | |||||||||
| WBsf1015055 | |||||||||
| WBsf226791 | |||||||||
| WBsf226792 | |||||||||
| Experimental_info | RNAi_result (28) | ||||||||
| Expr_pattern | Expr1024502 | ||||||||
| Expr1038917 | |||||||||
| Expr1156757 | |||||||||
| Expr2012020 | |||||||||
| Expr2030256 | |||||||||
| Drives_construct | WBCnstr00025138 | ||||||||
| Construct_product | WBCnstr00025138 | ||||||||
| Antibody | WBAntibody00002201 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (87) | |||||||||
| Interaction | WBInteraction000051783 | ||||||||
| WBInteraction000051784 | |||||||||
| WBInteraction000051785 | |||||||||
| WBInteraction000198930 | |||||||||
| WBInteraction000201909 | |||||||||
| WBInteraction000277157 | |||||||||
| WBInteraction000449622 | |||||||||
| WBInteraction000563416 | |||||||||
| WBInteraction000563417 | |||||||||
| WBInteraction000563418 | |||||||||
| Map_info | Map | III | Position | -1.40795 | Error | 9.2e-05 | |||
| Positive | Positive_clone | T12A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
