WormBase Tree Display for Gene: WBGene00000794
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| WBGene00000794 | Evidence | Paper_evidence | WBPaper00005857 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y47G6A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | crn-1 | Person_evidence | WBPerson1606 | |||||
| Sequence_name | Y47G6A.8 | ||||||||
| Molecular_name | Y47G6A.8 | ||||||||
| Y47G6A.8.1 | |||||||||
| CE22109 | |||||||||
| Other_name | fen-1 | Paper_evidence | WBPaper00036708 | ||||||
| CELE_Y47G6A.8 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | crn-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | crn | ||||||||
| Allele (53) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (37) | |||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00009731 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00020442 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019004 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | crn-1 encodes a cell death-related nuclease and is a 5'-3' exonuclease, a protein homologous to mammalian flap endonuclease 1 (FEN1); crn-1 also has endonuclease activity; crn-1 is essential for embryonic development and promotes cell death; CRN-1 binds the endonuclease CPS-6 in interaction experiments and each of these proteins can enhance the others's endonuclease activity; crn-1 is believed to function in a large multinuclease complex, the degradeosome, whose components include the protein products of cps-6, crn-5, crn-4, cpy-13 and other non-nuclease components like wah-1, to promote apoptotic DNA degradation; crn-1 is ubiquitously expressed and localizes to the nucleus. | Paper_evidence | WBPaper00005857 | |||||
| WBPaper00005978 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 22 Oct 2010 00:00:00 | ||||||||
| Automated_description | Enables flap endonuclease activity. Involved in apoptotic DNA fragmentation. Located in nucleus. Expressed widely. Human ortholog(s) of this gene implicated in breast cancer. Is an ortholog of human FEN1 (flap structure-specific endonuclease 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3650) | ||||
| Molecular_info | Corresponding_CDS | Y47G6A.8 | |||||||
| Corresponding_transcript | Y47G6A.8.1 | ||||||||
| Other_sequence (45) | |||||||||
| Associated_feature | WBsf656120 | ||||||||
| WBsf217401 | |||||||||
| WBsf217402 | |||||||||
| Experimental_info | RNAi_result (51) | ||||||||
| Expr_pattern | Expr2585 | ||||||||
| Expr11817 | |||||||||
| Expr1025800 | |||||||||
| Expr1030493 | |||||||||
| Expr1160283 | |||||||||
| Expr2010536 | |||||||||
| Expr2028776 | |||||||||
| Drives_construct | WBCnstr00010862 | ||||||||
| WBCnstr00019439 | |||||||||
| WBCnstr00037272 | |||||||||
| Construct_product | WBCnstr00010862 | ||||||||
| WBCnstr00019439 | |||||||||
| WBCnstr00037272 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (145) | |||||||||
| Interaction (190) | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| WBbiopr:00000103 | |||||||||
| Map_info | Map | I | Position | -3.20961 | Error | 0.004142 | |||
| Positive | Positive_clone | Y47G6A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
