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WormBase Tree Display for Gene: WBGene00020397

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Name Class

WBGene00020397SMapS_parentSequenceT10B11
IdentityVersion2
NameCGC_namepcbd-1Person_evidenceWBPerson384
Sequence_nameT10B11.1
Molecular_nameT10B11.1
T10B11.1.1
CE39768
Other_nameCELE_T10B11.1Accession_evidenceNDBBX284601
Public_namepcbd-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:03WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
228 Sep 2005 14:40:43WBPerson2970Name_changeCGC_namepcbd-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpcbd
Allele (17)
StrainWBStrain00024122
RNASeq_FPKM (74)
GO_annotation00098023
00098024
00098025
00098026
00125037
00125038
Ortholog (36)
Structured_descriptionConcise_descriptionpcbd-1 is orthologous to the human gene PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE (PCBD or TCF1; OMIM:126090), which when mutated leads to hyperphenylalaninemia with primapterinuria.Person_evidenceWBPerson384
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated24 May 2010 00:00:00
Automated_descriptionPredicted to enable 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. Predicted to be involved in tetrahydrobiopterin biosynthetic process. Expressed in head; hypodermis; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia D. Is an ortholog of human PCBD1 (pterin-4 alpha-carbinolamine dehydratase 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0081131Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:8646)
Molecular_infoCorresponding_CDST10B11.1
Corresponding_CDS_historyT10B11.1:wp154
Corresponding_transcriptT10B11.1.1
Other_sequence (73)
Associated_featureWBsf643418
WBsf655782
WBsf217926
Experimental_infoRNAi_resultWBRNAi00052994Inferred_automaticallyRNAi_primary
WBRNAi00081099Inferred_automaticallyRNAi_primary
WBRNAi00004194Inferred_automaticallyRNAi_primary
WBRNAi00035408Inferred_automaticallyRNAi_primary
WBRNAi00117094Inferred_automaticallyRNAi_primary
Expr_patternExpr11445
Expr12167
Expr1027403
Expr1038892
Expr1156597
Expr2014773
Expr2033007
Drives_constructWBCnstr00020338
WBCnstr00020345
WBCnstr00025171
Construct_productWBCnstr00025171
Microarray_results (18)
Expression_clusterWBPaper00031040:TGF-beta_adult_upregulated
WBPaper00033065:isp-1-1(qm150)_upregulated
WBPaper00035073:mitochondria_protein
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:dopaminergic-neurons_larva_enriched
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:hypodermis_larva_enriched
WBPaper00038118:aak-2(gt33)_downregulated
WBPaper00038168:lin-15B(n744)_downregulated
WBPaper00038237:age-1_upregulated_intestine_rescue
WBPaper00038237:age-1_upregulated_neuron_rescue
WBPaper00038237:age-1_upregulated_nontransgenic
WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
WBPaper00044005:DAF-16_upregulated
WBPaper00044638:daf-2(e1370)rsks-1(ok1255)_regulated
WBPaper00044736:flat_dev_expression
WBPaper00045316:prg-1_downregulated_L2
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_upregulated
WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046337:monosomal_N2_vs_daf-2_downregulated
WBPaper00046805:csr-1(RNAi)_upregulated_Set1
WBPaper00048923:Aging_regulated
WBPaper00048926:miaserin_upregulated_adult-day5
WBPaper00048988:neuron_expressed
WBPaper00049368:daf-2(e1370)_upregulated
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
WBPaper00049942:HeatShock_upregulated_hsf-1(+)
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050801:DPY-21_dauer_regulome
WBPaper00050990:intestine_enriched
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00051558:fog-2(q71)_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053388:dauer_regulated_Cluster3
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055386:daf-2(e1370)_upregulated
WBPaper00055482:pmt-2(RNAi)_downregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00056034:pals-25(jy9)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium
WBPaper00057288:Cold_downregulated_transcript
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_protein
WBPaper00059471:EGL-43_interacting
WBPaper00059816:crh-1(n3315)_downrgulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060100:SiNP_downregulated_mRNA
WBPaper00060278:atp-2(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061274:hypergravity_15xg_downregulated
WBPaper00061340:AIY
WBPaper00061340:hyp4_hyp5_hyp6
WBPaper00061340:hyp7_AB_lineage
WBPaper00061340:hyp7_C_lineage
WBPaper00061340:P_cell
WBPaper00061340:Tail_hypodermis
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061527:F54D5.3_7003-F54D5.3_7004
WBPaper00061651:ADE_enriched
WBPaper00061651:AWC_OFF_enriched
WBPaper00061651:AWC_ON_enriched
WBPaper00061651:CAN_enriched
WBPaper00061651:CEP_enriched
WBPaper00061651:FLP_enriched
WBPaper00061651:HSN_enriched
WBPaper00061651:NSM_enriched
WBPaper00061651:PDE_enriched
WBPaper00061651:PVD_enriched
WBPaper00061651:VC_4_5_enriched
WBPaper00061651:VC_enriched
WBPaper00061699:daf-18(ok480)_downregulated
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064130:Beta-Amyloid_downregulated_protein
WBPaper00064315:mes-4(bn73)_upregulated_EGCs
WBPaper00064769:him-17(me24)_upregulated
WBPaper00064992:Eugenol_downregulated
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066038:mip-1(how5)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
cgc4386_cluster_2_6
cgc4489_group_9
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Enriched_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00030839:Embryo_A_Class
WBPaper00032948:StarveUp2
WBPaper00034757:down_by_oxidative_stress
WBPaper00036286:Pattern_I
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
WBPaper00040210:Chlorpyrifos_24C_regulated
WBPaper00040858:eQTL_regulated_old
WBPaper00040858:eQTL_regulated_reproductive
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00041960:N2_fasting_upregulated_anytime
WBPaper00045015:acs-3(ft5)_downregulated
WBPaper00045015:nhr-25(RNAi)_downregulated
WBPaper00045960:L1-L4-lethargus_downregulated
WBPaper00045960:L4-lethargus_downregulated
WBPaper00053236:daf-16(mgDF50)_regulated_Starved
WBPaper00053236:Starvation_regulated_GR1307
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
Interaction (16)
Map_infoMapIPosition1.5698Error0.011368
PositivePositive_cloneT10B11Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5509
Pseudo_map_position
ReferenceWBPaper00034518
WBPaper00034662
WBPaper00038491
WBPaper00046585
WBPaper00055090
WBPaper00064339
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene