WormBase Tree Display for Gene: WBGene00020297

WBGene00020297 SMap: S_parent: Sequence: T07A9
  Identity: Version: 3
    Name: CGC_name: nog-1 Paper_evidence: WBPaper00044873
      Sequence_name: T07A9.9
      Molecular_name: T07A9.9
        T07A9.9.1
        CE17218
        T07A9.9.2
        T07A9.9.3
      Other_name: phi-58 Person_evidence: WBPerson2582
        CELE_T07A9.9 Accession_evidence: NDB BX284604
      Public_name: nog-1
    DB_info: Database: AceView gene 4B149
        WormQTL gene WBGene00020297
        WormFlux gene WBGene00020297
        NDB locus_tag CELE_T07A9.9
        Panther gene CAEEL|WormBase=WBGene00020297|UniProtKB=O44411
          family PTHR45759
        NCBI gene 176863
        RefSeq protein NM_171242.6
        SwissProt UniProtAcc O44411
        UniProt_GCRP UniProtAcc O44411
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:02 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 17 Mar 2005 13:54:35 WBPerson2970 Name_change: Other_name: phi-58
        3 28 Jan 2015 11:26:55 WBPerson2970 Name_change: CGC_name: nog-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nog
    Allele (50)
    Strain: WBStrain00051201
    RNASeq_FPKM (74)
    GO_annotation (17)
    Contained_in_operon: CEOP4020
    Ortholog (44)
    Paralog: WBGene00010805 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00012126 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015346 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016145 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: T07A9.9 encodes a GTPase with similarity to the mammalian CRFG proteins and Saccharomyces cerevisiae nucleolar NOG1 involved in biogenesis of the 60S ribosomal subunit; in C. elegans, T07A9.9 plays a role in regulating growth, development, lifespan, and fat metabolism; T07A9.9::GFP reporter fusions expressed ubiquitously throughout the life cycle and localizes to the nucleus; in intestinal cells, a T07A9.9 reporter fusion localizes to the nucleolus. Paper_evidence: WBPaper00044873
          Curator_confirmed: WBPerson1843
          Date_last_updated: 22 Jan 2015 00:00:00
      Automated_description: Predicted to enable GTPase activity and RNA binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of lipid storage; and regulation of reproductive process. Located in nucleolus. Expressed in several structures, including excretory cell; germ cell; intestine; pharynx; and vulva. Is an ortholog of human GTPBP4 (GTP binding protein 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T07A9.9
    Corresponding_CDS_history: T07A9.9b:wp261
      T07A9.9c:wp239
      T07A9.9c:wp261
    Corresponding_transcript: T07A9.9.1
      T07A9.9.2
      T07A9.9.3
    Other_sequence (82)
    Associated_feature: WBsf645755
      WBsf659874
      WBsf659875
      WBsf995139
      WBsf1016545
      WBsf227838
      WBsf227839
  Experimental_info: RNAi_result (26)
    Expr_pattern: Expr12046
      Expr12047
      Expr12048
      Expr1029145
      Expr1038842
      Expr1156319
      Expr2014347
      Expr2032588
    Drives_construct: WBCnstr00020132
      WBCnstr00020133
      WBCnstr00025236
    Construct_product: WBCnstr00020133
      WBCnstr00020280
      WBCnstr00025236
    Microarray_results (45)
    Expression_cluster: WBPaper00028451:Abundant_spermatogenesis_enriched
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032528:L3_enriched
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040990:PA14_upregulated
      WBPaper00041257:irradiation_upregulated
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00048810:CoQ-deficiency_upregulated
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_downregulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00055013:HMG-3_interacting_protein
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00059605:MUT-16_interacting
      WBPaper00059895:wounding_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061340:M_cell
      WBPaper00061527:B0511.6_180-Y54E10BR.4_1509
      WBPaper00061651:Germline_enriched
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062590:Aging_upregulated_neuron
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-3(bn199)_downregulated_PGCs
      WBPaper00064315:mes-4(bn73)_downregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064871:hypoxia_downregulated_F3
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:11_0
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_transcript
      WBPaper00065945:global-rpoa-2(-)_upregulated_transcript
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      cgc4489_group_12
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025032:cluster_2
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031060:2-deoxy-D-glucose_upregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp3
      WBPaper00035227:heat_shock_regulated
      WBPaper00037695:WC_5-day
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00047070:DAF-16-dependent_UV_response
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00050538:Fasting_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      [cgc5767]:cluster_16
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:oogenesis-enriched
    Interaction (229)
    WBProcess: WBbiopr:00000001
      WBbiopr:00000121
  Map_info: Map: IV Position: -26.208
    Positive: Positive_clone: T07A9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00028451
    WBPaper00038491
    WBPaper00044873
    WBPaper00049828
    WBPaper00055090
    WBPaper00057242
    WBPaper00065861
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene