WormBase Tree Display for Gene: WBGene00018285
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| WBGene00018285 | SMap | S_parent | Sequence | F41E6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | smk-1 | Paper_evidence | WBPaper00027157 | |||||
| Sequence_name | F41E6.4 | ||||||||
| Molecular_name | F41E6.4a | ||||||||
| F41E6.4a.1 | |||||||||
| CE41239 | |||||||||
| F41E6.4b | |||||||||
| CE41240 | |||||||||
| F41E6.4b.1 | |||||||||
| F41E6.4b.2 | |||||||||
| F41E6.4c | |||||||||
| Other_name | rad-2 | Paper_evidence | WBPaper00031061 | ||||||
| CELE_F41E6.4 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | smk-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 03 Apr 2006 17:19:49 | WBPerson2970 | Name_change | CGC_name | smk-1 | ||||
| 3 | 22 Oct 2007 11:48:38 | WBPerson2970 | Event | Acquires_merge | WBGene00004289 | ||||
| Name_change | Other_name | rad-2 | |||||||
| Acquires_merge | WBGene00004289 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | smk | ||||||||
| Reference_allele | WBVar00089072 | ||||||||
| Allele (93) | |||||||||
| Strain | WBStrain00002686 | ||||||||
| WBStrain00034248 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (49) | |||||||||
| Structured_description | Concise_description | smk-1 encodes a novel, evolutionarily conserved protein that is orthologous to the mammalian and Dictyostelium discoideum SMEK (suppressor of MEK null) proteins; smk-1 activity is essential for several aspects of DAF-16-mediated longevity namely, the defense response to pathogenic bacteria and increased resistance to oxidative and UV-induced damage; in regulating DAF-16 activity, SMK-1 appears to act by affecting the transcription of DAF-16 target genes, such as sod-3, ctl-1, and lys-8; SMK-1 is present in the nucleus of intestinal cells, many head and tail neurons, and some hypodermal cells throughout development. | Paper_evidence | WBPaper00027157 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Sep 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein phosphatase activator activity. Involved in several processes, including defense response to bacterium; negative regulation of mitotic DNA damage checkpoint; and response to radiation. Located in nucleus. Expressed in hypodermis; intestine; and tail. Is an ortholog of human PPP4R3A (protein phosphatase 4 regulatory subunit 3A) and PPP4R3B (protein phosphatase 4 regulatory subunit 3B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F41E6.4a | |||||||
| F41E6.4b | |||||||||
| Corresponding_CDS_history | F41E6.4a:wp137 | ||||||||
| F41E6.4a:wp177 | |||||||||
| F41E6.4b:wp177 | |||||||||
| F41E6.4c:wp254 | |||||||||
| Corresponding_transcript | F41E6.4c | ||||||||
| F41E6.4a.1 | |||||||||
| F41E6.4b.1 | |||||||||
| F41E6.4b.2 | |||||||||
| Other_sequence (35) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result (50) | ||||||||
| Expr_pattern | Expr3839 | ||||||||
| Expr3840 | |||||||||
| Expr6028 | |||||||||
| Expr1010585 | |||||||||
| Expr1037875 | |||||||||
| Expr1150858 | |||||||||
| Expr2015919 | |||||||||
| Expr2034152 | |||||||||
| Drives_construct | WBCnstr00003227 | ||||||||
| WBCnstr00011690 | |||||||||
| WBCnstr00026637 | |||||||||
| Construct_product | WBCnstr00011690 | ||||||||
| WBCnstr00026637 | |||||||||
| Microarray_results (40) | |||||||||
| Expression_cluster (121) | |||||||||
| Interaction (333) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | V | Position | 1.48475 | Error | 0.002222 | |||
| Positive | Positive_clone | F41E6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 362 | |||||||
| 363 | |||||||||
| 5716 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (48) | |||||||||
| Remark | |||||||||
| Method | Gene |
