WormBase Tree Display for Gene: WBGene00018285

WBGene00018285 SMap: S_parent: Sequence: F41E6
  Identity: Version: 3
    Name: CGC_name: smk-1 Paper_evidence: WBPaper00027157
      Sequence_name: F41E6.4
      Molecular_name: F41E6.4a
        F41E6.4a.1
        CE41239
        F41E6.4b
        CE41240
        F41E6.4b.1
        F41E6.4b.2
        F41E6.4c
      Other_name: rad-2 Paper_evidence: WBPaper00031061
        CELE_F41E6.4 Accession_evidence: NDB BX284605
      Public_name: smk-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 03 Apr 2006 17:19:49 WBPerson2970 Name_change: CGC_name: smk-1
        3 22 Oct 2007 11:48:38 WBPerson2970 Event: Acquires_merge: WBGene00004289
              Name_change: Other_name: rad-2
      Acquires_merge: WBGene00004289
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: smk
    Reference_allele: WBVar00089072
    Allele (93)
    Strain: WBStrain00002686
      WBStrain00034248
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog: WBGene00062053 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00024707 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            Inparanoid_8
            WormBase-Compara
      WBGene00156217 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00132704 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00191156 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00116514 Pristionchus pacificus From_analysis: Inparanoid_8
      CBOVI.g75 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g13146 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g20864 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g1990 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g19937 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g16429 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g7257 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g12821 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g12617 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g12618 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g22729 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g25188 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g6674 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g2804 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00027.g1651 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-smk-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold541.g3389 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00857.g16161 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_00857.g16162 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_21769 Caenorhabditis latens From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g00378 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g09501 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g12663 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50116900 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g15031 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00082505 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00243528 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00280588 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00265283 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00288975 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000005145 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0024555 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-8142 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-030131-3958 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:20219 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:29267 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:33146 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1915984 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2144474 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:3588287 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:3588286 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1309059 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1309450 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Structured_description: Concise_description: smk-1 encodes a novel, evolutionarily conserved protein that is orthologous to the mammalian and Dictyostelium discoideum SMEK (suppressor of MEK null) proteins; smk-1 activity is essential for several aspects of DAF-16-mediated longevity namely, the defense response to pathogenic bacteria and increased resistance to oxidative and UV-induced damage; in regulating DAF-16 activity, SMK-1 appears to act by affecting the transcription of DAF-16 target genes, such as sod-3, ctl-1, and lys-8; SMK-1 is present in the nucleus of intestinal cells, many head and tail neurons, and some hypodermal cells throughout development. Paper_evidence: WBPaper00027157
          Curator_confirmed: WBPerson1843
          Date_last_updated: 12 Sep 2006 00:00:00
      Automated_description: Predicted to enable protein phosphatase activator activity. Involved in several processes, including defense response to bacterium; negative regulation of mitotic DNA damage checkpoint; and response to radiation. Located in nucleus. Expressed in hypodermis; intestine; and tail. Is an ortholog of human PPP4R3A (protein phosphatase 4 regulatory subunit 3A) and PPP4R3B (protein phosphatase 4 regulatory subunit 3B). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F41E6.4a
      F41E6.4b
    Corresponding_CDS_history: F41E6.4a:wp137
      F41E6.4a:wp177
      F41E6.4b:wp177
      F41E6.4c:wp254
    Corresponding_transcript: F41E6.4c
      F41E6.4a.1
      F41E6.4b.1
      F41E6.4b.2
    Other_sequence (35)
    Associated_feature (15)
  Experimental_info: RNAi_result (50)
    Expr_pattern: Expr3839
      Expr3840
      Expr6028
      Expr1010585
      Expr1037875
      Expr1150858
      Expr2015919
      Expr2034152
    Drives_construct: WBCnstr00003227
      WBCnstr00011690
      WBCnstr00026637
    Construct_product: WBCnstr00011690
      WBCnstr00026637
    Microarray_results (40)
    Expression_cluster (121)
    Interaction (333)
    WBProcess: WBbiopr:00000001
      WBbiopr:00000039
  Map_info: Map: V Position: 1.48475 Error: 0.002222
    Positive: Positive_clone: F41E6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 362
        363
        5716
    Pseudo_map_position
  Reference (48)
  Remark
  Method: Gene