WormBase Tree Display for Gene: WBGene00016541

WBGene00016541 SMap: S_parent: Sequence: C39H7
  Identity: Version: 2
    Name: CGC_name: ttbk-8.2 Person_evidence: WBPerson555
            WBPerson298
          Laboratory_evidence: GNW
          Remark: A Wormbase user kindly pointed out the similarity between TTBK-2 and R13H9.5, which led us to review the entire class, resulting in several re-naming events
      Sequence_name: C39H7.1
      Molecular_name: C39H7.1
        C39H7.1.1
        CE06942
      Other_name: CELE_C39H7.1 Accession_evidence: NDB BX284604
      Public_name: ttbk-8.2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 22 Jun 2022 09:37:14 WBPerson21950 Name_change: CGC_name: ttbk-8.2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ttbk
    Allele (26)
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (52)
    Paralog (93)
    Structured_description: Automated_description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in signal transduction. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Is an ortholog of human TTBK1 (tau tubulin kinase 1) and TTBK2 (tau tubulin kinase 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050961 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:19141)
  Molecular_info: Corresponding_CDS: C39H7.1
    Corresponding_transcript: C39H7.1.1
    Other_sequence (41)
    Associated_feature: WBsf996559
      WBsf996560
      WBsf1017404
      WBsf228324
  Experimental_info: RNAi_result: WBRNAi00011799 Inferred_automatically: RNAi_primary
      WBRNAi00042233 Inferred_automatically: RNAi_primary
      WBRNAi00002170 Inferred_automatically: RNAi_primary
      WBRNAi00029698 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1027068
      Expr1146223
      Expr2001545
      Expr2019766
    Microarray_results (22)
    Expression_cluster: WBPaper00028451:Abundant_spermatogenesis_enriched
      WBPaper00029047:atx-3_upregulated
      WBPaper00031070:rrf-3_eri-1_upregulated
      WBPaper00032479:CB4856vsN2_LifeStageProfile_Variation
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:isp-1-1(qm150)_downregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00040560:hpl-2_embryo_downregulated
      WBPaper00041954:ethanol_upregulated
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00043945:MeHg_downregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044260:nicotinc-acid_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044616:alg-3-4_downregulated_gene
      WBPaper00044736:rising_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00044760:germline_specific
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045521:Spermatogenic
      WBPaper00045729:gld-2(RNAi)_upregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00045809:rsd-2(yp10)_downregulated
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00046421:cdc-48.2(tm659)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046741:Garlic-Extract_downregulated_mRNA
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00046805:csr-1(RNAi)_upregulated_Set2
      WBPaper00046805:P-granule-RNAi_upregulated_Set1
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048762:FOG-3_associated
      WBPaper00048988:neuron_expressed
      WBPaper00049290:rsks-1(sv31)_downregulated
      WBPaper00049417:B.animalis_upregulated
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049498:npr-1(ur89)_regulated_2
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr)
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050231:male_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051265:F1_hrde-1(tm1200)_upregulated
      WBPaper00051265:F1_morc-1(tm6048)_upregulated
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051404:alg-2(ok304)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053318:mir-71(n4115)_downregulated_mRNA
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053657:JU2519_M.humicola-infection_24hr
      WBPaper00053664:ins-11(tm1053)_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00054410:set-9(rw5)_downregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055648:sperm_expressed
      WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056039:ptl-1(ok621)_downregulated
      WBPaper00056039:ptrn-1(tm5597)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:flcn-1(ok975)_downregulated
      WBPaper00056586:kri-1(ok1251)_upregulated
      WBPaper00056731:human-amylin_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057068:numr-1(RNAi)_upregulated
      WBPaper00057068:numr-1(RNAi)_upregulated_Cadmium
      WBPaper00057347:nhr-14(tm1473)_upreglated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_upregulated
      WBPaper00058955:heatshock_upregulated_CE
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059175:hlh-17p-XBP-1_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059426:Ag-nanoparticles_upregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059605:mut-16(pk710)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060224:atf-6(ok551)_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060526:plp-1(ok2155)_upregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060911:prx-5(RNAi)_downregulated_mRNA
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00060921:tbh-1(ok1196)_downregulated
      WBPaper00061040:eat-2(ad1116)_downregulated
      WBPaper00061045:Y56A3A.22(cck200)_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061340:ADE
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061479:hda-1(ne4747)_upregulated
      WBPaper00061479:hda-1(ne4748)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:F07A5.2-R10E9.2
      WBPaper00061572:oleic-acid-specific_mating_upregulated
      WBPaper00061651:Sperm_enriched
      WBPaper00061853:osm-3(dh441)_downregulated
      WBPaper00061853:osm-3(dh441)_downregulated_tunicamycin
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062456:doxycycline_upregulated_CB4856_transcript
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064158:xpo-1(RNAi)_downregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064473:ets-4(rrr16)_upregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_upregulated_starved
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064999:miR-229-64-65-66_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C
      WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065734:unc-25(e156)_downregulated
      WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_upregulated_N2
      WBPaper00065841:3_3
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066085:hda-3(ok1991)_upregulated
      WBPaper00066093:E.coli-purE_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066118:cyclobutrifluram_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      cgc4489_group_11
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00028948:cep-1(gk138)+UV_downregulated
      WBPaper00028948:cep-1(gk138)_upregulated
      WBPaper00029437:rde-4_upregulated
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00031184:acrylamide_upregulated
      WBPaper00033101:spr-5_regulated
      WBPaper00034661:AgNPs_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00035891:zip-2(RNAi)_downregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_E
      WBPaper00037113:CPF_16C_down-regulated
      WBPaper00038172:aak-2overexpression_up_regulated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040963:Q50_up
      WBPaper00040963:Q100_up
      WBPaper00040963:Q200_up
      WBPaper00040963:TA100_up
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HQ_3d_0.2mM_Up
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00042178:hlh-29(tm284)_upregulated
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045263:ProLongevity-mtROS_downregulated
      WBPaper00045673:colistin_downregulated
      WBPaper00046639:tyrosol_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00051387:Triclosan_downregulated
      [cgc6390]:Cluster_D
      [cgc6390]:spermatogenesis-enriched
    Interaction (244)
  Map_info: Map: IV Position: 1.97401
    Positive: Positive_clone: C39H7 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027258
    WBPaper00057218
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene