WormBase Tree Display for Gene: WBGene00015648

WBGene00015648 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 3
    Name: CGC_name: orai-1 Person_evidence: WBPerson1851
      Sequence_name: C09F5.2
      Molecular_name: C09F5.2a
        C09F5.2a.1
        CE42990
        C09F5.2b
        CE01774
        C09F5.2a.2
        C09F5.2b.1
      Other_name: CELE_C09F5.2 Accession_evidence: NDB BX284603
      Public_name: orai-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:56 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 18 Jul 2006 14:35:12 WBPerson2970 Name_change: CGC_name: orai-1
        3 03 Nov 2008 13:42:45 WBPerson1867 Event: Acquires_merge: WBGene00021065
      Acquires_merge: WBGene00021065
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: orai
    Allele: WBVar01951133
      WBVar01951134
      WBVar02069490
      WBVar01951135
      WBVar01951136
      WBVar01500082
      WBVar00005816
      WBVar00005821
      WBVar00251377
      WBVar00005826
      WBVar00005831
      WBVar00005836
      WBVar01254846
      WBVar01254847
      WBVar01254848
      WBVar01254849
      WBVar00255260
      WBVar01254852
      WBVar01443163
      WBVar01443166
      WBVar01700397
      WBVar01443167
      WBVar01903309
      WBVar01903310
      WBVar01903311
      WBVar02108864
      WBVar01903312
      WBVar00798426
      WBVar00798427
      WBVar01903313
      WBVar01903314
      WBVar00798428
      WBVar02030124
      WBVar00798429
      WBVar01903315
      WBVar02030125
      WBVar01903316
      WBVar00798430
      WBVar02030126
      WBVar01903317
      WBVar00798431
      WBVar01903318
      WBVar01498832
      WBVar00798432
      WBVar01903319
      WBVar00798433
      WBVar00798434
      WBVar01903320
      WBVar00798435
      WBVar00798436
      WBVar00798437
      WBVar00798438
      WBVar00798439
      WBVar01769029
      WBVar00798440
      WBVar01769030
      WBVar00798441
      WBVar00798442
      WBVar01769031
      WBVar01769032
      WBVar00798443
      WBVar00798444
      WBVar01769033
      WBVar00798445
      WBVar01769034
      WBVar01769035
      WBVar00798446
      WBVar00798447
      WBVar01564174
      WBVar01564175
      WBVar00798448
      WBVar01564176
      WBVar00798449
      WBVar01655583
      WBVar01564177
      WBVar00798450
      WBVar01564178
      WBVar00798451
      WBVar01917682
      WBVar01495171
      WBVar00798452
      WBVar01564179
      WBVar01564180
      WBVar01917683
      WBVar00798453
      WBVar01564181
      WBVar00798454
      WBVar02012615
      WBVar01564182
      WBVar00798455
      WBVar02012616
      WBVar01564183
      WBVar00798456
      WBVar01983496
      WBVar00798457
      WBVar01564184
      WBVar01389307
      WBVar00798458
      WBVar00798459
      WBVar00798460
      WBVar00798461
      WBVar00798462
      WBVar00798463
      WBVar00798464
      WBVar00798465
      WBVar00798466
      WBVar00798467
      WBVar02045644
      WBVar00798468
      WBVar00798469
      WBVar02131385
      WBVar00798470
      WBVar02131386
      WBVar00798471
      WBVar01499792
      WBVar00798472
      WBVar00798473
      WBVar01499793
      WBVar00798474
      WBVar00798475
      WBVar00798476
      WBVar00798477
      WBVar00798478
      WBVar00798479
      WBVar00798480
      WBVar00798481
      WBVar00798482
      WBVar00798483
      WBVar00798484
      WBVar00798485
      WBVar01479019
      WBVar01479020
      WBVar01479021
      WBVar01479022
      WBVar00388297
      WBVar01271807
      WBVar00388298
      WBVar00030783
      WBVar00388299
      WBVar00388300
      WBVar00388301
      WBVar00030788
      WBVar01271818
      WBVar00388302
      WBVar00388303
      WBVar00388304
      WBVar00030793
      WBVar00388305
      WBVar00388306
      WBVar00388307
      WBVar00388308
      WBVar00030803
      WBVar01271829
      WBVar00388309
      WBVar00388310
      WBVar00030808
      WBVar00030813
      WBVar01271840
      WBVar00030818
      WBVar00030828
      WBVar00030833
      WBVar00030838
      WBVar01400244
      WBVar00095402
      WBVar00095403
      WBVar02106761
      WBVar01401084
      WBVar02106762
      WBVar00030843
      WBVar00030848
      WBVar01400255
      WBVar00030858
      WBVar01395629
      WBVar00030863
      WBVar00246650
      WBVar01400267
      WBVar01951129
      WBVar00263327
      WBVar01951131
    Strain: WBStrain00002066
    RNASeq_FPKM (74)
    GO_annotation (16)
    Contained_in_operon: CEOP3859
    Ortholog (46)
    Structured_description: Concise_description: orai-1 encodes a calcium release activated calcium (CRAC) channel orthologous to the vertebrate ORAI family of proteins; ORAI-1 activity is required for normal levels of fertility and for store-operated calcium channel (SOCC) activity in intestinal epithelial cells; co-expression of ORAI-1 and STIM-1 in HEK293 cells results in large inwardly rectifying cation currents activated by endoplasmic reticulum calcium depletion; ORAI-1 is expressed in the gonad and in the intestine; in the intestine, ORAI-1 appears to localize to the apical and basal plasma membrane; in the spermatheca, ORAI-1 expression is consistent with localization to the basal plasma membrane. Paper_evidence: WBPaper00028994
          Curator_confirmed: WBPerson1843
          Date_last_updated: 21 May 2014 00:00:00
      Automated_description: Enables store-operated calcium channel activity. Involved in ovulation and store-operated calcium entry. Located in apical plasma membrane and basolateral plasma membrane. Part of voltage-gated calcium channel complex. Expressed in gonadal sheath cell; head; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Is an ortholog of human ORAI2 (ORAI calcium release-activated calcium modulator 2) and ORAI3 (ORAI calcium release-activated calcium modulator 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080686 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:25896)
      DOID:0111976 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:25896)
  Molecular_info: Corresponding_CDS: C09F5.2a
      C09F5.2b
    Corresponding_CDS_history: C09F5.2:wp194
    Corresponding_transcript: C09F5.2a.1
      C09F5.2a.2
      C09F5.2b.1
    Other_sequence (41)
    Associated_feature (13)
  Experimental_info: RNAi_result: WBRNAi00090597 Inferred_automatically: RNAi_primary
      WBRNAi00028729 Inferred_automatically: RNAi_primary
      WBRNAi00010525 Inferred_automatically: RNAi_primary
      WBRNAi00085731 Inferred_automatically: RNAi_primary
      WBRNAi00001126 Inferred_automatically: RNAi_primary
      WBRNAi00054897 Inferred_automatically: RNAi_primary
      WBRNAi00040207 Inferred_automatically: RNAi_primary
      WBRNAi00006596 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram2030
      Expr4783
      Expr5220
      Expr5221
      Expr1013330
      Expr1036702
      Expr1144278
      Expr2014632
      Expr2032865
    Drives_construct: WBCnstr00002229
      WBCnstr00004260
      WBCnstr00008590
      WBCnstr00012242
      WBCnstr00028687
    Construct_product: WBCnstr00008590
      WBCnstr00012242
      WBCnstr00028687
    Microarray_results (31)
    Expression_cluster (107)
    Interaction: WBInteraction000556188
      WBInteraction000556189
      WBInteraction000556190
      WBInteraction000556191
  Map_info: Map: III Position: -26.3293 Error: 0.015704
    Positive: Positive_clone: C09F5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00028994
    WBPaper00030263
    WBPaper00038491
    WBPaper00047380
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene