WormBase Tree Display for Gene: WBGene00015399

WBGene00015399 SMap: S_parent: Sequence: C03G6
  Identity: Version: 2
    Name: CGC_name: cyp-35A1
      Sequence_name: C03G6.14
      Molecular_name: C03G6.14
        C03G6.14.1
        CE52081
      Other_name: CELE_C03G6.14 Accession_evidence: NDB BX284605
      Public_name: cyp-35A1
    DB_info: Database: AceView gene 5H838
        WormQTL gene WBGene00015399
        WormFlux gene WBGene00015399
        NDB locus_tag CELE_C03G6.14
        Panther gene CAEEL|WormBase=WBGene00015399|UniProtKB=O02627
          family PTHR24300
        NCBI gene 182176
        RefSeq protein NM_001356694.2
        TrEMBL UniProtAcc O02627
        UniProt_GCRP UniProtAcc O02627
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:56 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-35A1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (40)
    Strain: WBStrain00032479
      WBStrain00036139
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (129)
    Paralog (44)
    Structured_description: Concise_description: cyp-35A1 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; RT-PCR experiments indicate that cyp-35A1 mRNA is upregulated in response to treatment with xenobiotics, such as PCBs (polychlorinated biphenyls) or PAHs (polycyclic aromatic hydrocarbons); loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds; inaddition, cyp-35A(RNAi) also results in a reduction of fat content. Paper_evidence: WBPaper00005655
            WBPaper00025207
          Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Feb 2009 00:00:00
      Automated_description: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2D6 (cytochrome P450 family 2 subfamily D member 6); and CYP2E1 (cytochrome P450 family 2 subfamily E member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (42)
  Molecular_info: Corresponding_CDS: C03G6.14
    Corresponding_CDS_history: C03G6.14:wp125
      C03G6.14:wp185
      C03G6.14:wp261
    Corresponding_transcript: C03G6.14.1
    Other_sequence: Dviv_isotig14097
      Dviv_isotig14098
      AM743893.1
      Oden_isotig18384
  Experimental_info: RNAi_result: WBRNAi00078473 Inferred_automatically: RNAi_primary
      WBRNAi00078474 Inferred_automatically: RNAi_primary
      WBRNAi00039542 Inferred_automatically: RNAi_primary
      WBRNAi00010067 Inferred_automatically: RNAi_primary
      WBRNAi00114817 Inferred_automatically: RNAi_primary
      WBRNAi00092681 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1017756
      Expr1143646
      Expr2010734
    Drives_construct: WBCnstr00028874
    Construct_product: WBCnstr00028874
    Microarray_results (15)
    Expression_cluster (111)
    Interaction (28)
  Map_info: Map: V Position: 0.708623 Error: 0.002847
    Positive: Positive_clone: C03G6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5576
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene