| WBGene00015399 | SMap | S_parent | Sequence | C03G6 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | cyp-35A1 |
| | | Sequence_name | C03G6.14 |
| | | Molecular_name | C03G6.14 |
| | | | C03G6.14.1 |
| | | | CE52081 |
| | | Other_name | CELE_C03G6.14 | Accession_evidence | NDB | BX284605 |
| | | Public_name | cyp-35A1 |
| | DB_info | Database | AceView | gene | 5H838 |
| | | | WormQTL | gene | WBGene00015399 |
| | | | WormFlux | gene | WBGene00015399 |
| | | | NDB | locus_tag | CELE_C03G6.14 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00015399|UniProtKB=O02627 |
| | | | | family | PTHR24300 |
| | | | NCBI | gene | 182176 |
| | | | RefSeq | protein | NM_001356694.2 |
| | | | TrEMBL | UniProtAcc | O02627 |
| | | | UniProt_GCRP | UniProtAcc | O02627 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 |
| | | | 2 | 21 Sep 2004 09:38:16 | WBPerson1971 | Name_change | CGC_name | cyp-35A1 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | cyp |
| | Allele (40) |
| | Strain | WBStrain00032479 |
| | | WBStrain00036139 |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Ortholog (129) |
| | Paralog (44) |
| | Structured_description | Concise_description | cyp-35A1 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; RT-PCR experiments indicate that cyp-35A1 mRNA is upregulated in response to treatment with xenobiotics, such as PCBs (polychlorinated biphenyls) or PAHs (polycyclic aromatic hydrocarbons); loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds; inaddition, cyp-35A(RNAi) also results in a reduction of fat content. | Paper_evidence | WBPaper00005655 |
| | | | | | WBPaper00025207 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 26 Feb 2009 00:00:00 |
| | | Automated_description | Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2D6 (cytochrome P450 family 2 subfamily D member 6); and CYP2E1 (cytochrome P450 family 2 subfamily E member 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (42) |
| Molecular_info | Corresponding_CDS | C03G6.14 |
| | Corresponding_CDS_history | C03G6.14:wp125 |
| | | C03G6.14:wp185 |
| | | C03G6.14:wp261 |
| | Corresponding_transcript | C03G6.14.1 |
| | Other_sequence | Dviv_isotig14097 |
| | | Dviv_isotig14098 |
| | | AM743893.1 |
| | | Oden_isotig18384 |
| Experimental_info | RNAi_result | WBRNAi00078473 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00078474 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00039542 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00010067 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00114817 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00092681 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1017756 |
| | | Expr1143646 |
| | | Expr2010734 |
| | Drives_construct | WBCnstr00028874 |
| | Construct_product | WBCnstr00028874 |
| | Microarray_results (15) |
| | Expression_cluster | WBPaper00004966:beta-Naphthoflavone_induced |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042194:nhr-114(RNAi)_downregulated |
| | | WBPaper00042194:Tryptophan_upregulated |
| | | WBPaper00045390:ubc-9(RNAi)_upregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048926:miaserin_upregulated_adult-day3 |
| | | WBPaper00048926:miaserin_upregulated_adult-day5 |
| | | WBPaper00048926:miaserin_upregulated_adult-day10 |
| | | WBPaper00049334:CE_intestine_enriched |
| | | WBPaper00049368:daf-2(e1370)_downregulated |
| | | WBPaper00049498:npr-1(ur89)_regulated_7 |
| | | WBPaper00050096:P.aeruginosa_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050561:indole_0.1mM-indole_upregulated |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00051021:4-bromodiphenyl-ether_upregulated |
| | | WBPaper00053295:lin-22(icb38)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053402:cco-1(RNAi)_downregulated |
| | | WBPaper00053771:up_at_3h-NaCl |
| | | WBPaper00053888:drh-3(rrr2)_upregulated |
| | | WBPaper00055013:hmg-3(bar24)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00056073:NHR-86_interacting_promoter |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056167:Cry5B_downregulated |
| | | WBPaper00056218:daf-16(mu86)_downregulated_Day7 |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1 |
| | | WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4 |
| | | WBPaper00057068:numr-1(RNAi)_upregulated |
| | | WBPaper00057068:numr-1(RNAi)_upregulated_Cadmium |
| | | WBPaper00058599:benzimidazoles_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00059191:hsp-16.2p-LIN-29_downregulated |
| | | WBPaper00059378:cec-4(ok3124);lmn-1(Y59C)_vs_lmn-1(Y59C)_upregulated |
| | | WBPaper00059604:fluvastatin_downregulated_dlk-1(km12) |
| | | WBPaper00059604:fluvastatin_downregulated_N2 |
| | | WBPaper00059754:C.neoformans_H99_upregulated |
| | | WBPaper00059754:E.faecalis_OG1RF_upregulated |
| | | WBPaper00060852:Benzo[a]pyrene_upregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640) |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061527:cyp-33C6-cyp-35B2 |
| | | WBPaper00061530:nhr-49(e2144)_downregulated |
| | | WBPaper00061590:CGP37157_upregulated |
| | | WBPaper00061636:atracurium_upregulated |
| | | WBPaper00061753:csr-1(tor159)_downregulated_20C |
| | | WBPaper00062156:jmjd-1.2(zr1010)_upregulated |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00064107:lin-35(n745)_upregulated |
| | | WBPaper00064539:nhr-114(gk849)_upregulated |
| | | WBPaper00064788:ketamine_upregulated |
| | | WBPaper00064992:Capsaicin_upregulated |
| | | WBPaper00064992:Eugenol_upregulated |
| | | WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal |
| | | WBPaper00065225:nhr-42(tm1375)_downregulated_S.aureus-infected |
| | | WBPaper00065288:mdt-15(tm2182)_downregulated |
| | | WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | WBPaper00066232:ash-2(RNAi)_upregulated_WT |
| | | WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2 |
| | | WBPaper00066232:hsf-1(RNAi)_upregulated_WT |
| | | cgc4489_group_4 |
| | | WBPaper00006465:II_ethanol_late_induction |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00041211:RPW-24_Up |
| | | WBPaper00041939:control_vs_EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00046083:oga-1(ok1207)_OP50_downregulated |
| | | WBPaper00046083:ogt-1(ok1474)_OP50_downregulated |
| | | WBPaper00046083:pmk-1(km25)_OP50_downregulated |
| | | WBPaper00046548:dafachronic-acid_upregulated |
| | | WBPaper00047021:MWCNT_upregulated |
| | | WBPaper00055899:2,4-Dinitroanisole_regulated |
| | | [cgc6390]:herm_soma-enriched |
| | Interaction (28) |
| Map_info | Map | V | Position | 0.708623 | Error | 0.002847 |
| | Positive | Positive_clone | C03G6 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5576 |
| | Pseudo_map_position |
| Reference (11) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
