WormBase Tree Display for Gene: WBGene00015399
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| WBGene00015399 | SMap | S_parent | Sequence | C03G6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cyp-35A1 | |||||||
| Sequence_name | C03G6.14 | ||||||||
| Molecular_name | C03G6.14 | ||||||||
| C03G6.14.1 | |||||||||
| CE52081 | |||||||||
| Other_name | CELE_C03G6.14 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | cyp-35A1 | ||||||||
| DB_info | Database | AceView | gene | 5H838 | |||||
| WormQTL | gene | WBGene00015399 | |||||||
| WormFlux | gene | WBGene00015399 | |||||||
| NDB | locus_tag | CELE_C03G6.14 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00015399|UniProtKB=O02627 | |||||||
| family | PTHR24300 | ||||||||
| NCBI | gene | 182176 | |||||||
| RefSeq | protein | NM_001356694.2 | |||||||
| TrEMBL | UniProtAcc | O02627 | |||||||
| UniProt_GCRP | UniProtAcc | O02627 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 21 Sep 2004 09:38:16 | WBPerson1971 | Name_change | CGC_name | cyp-35A1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyp | ||||||||
| Allele (40) | |||||||||
| Strain | WBStrain00032479 | ||||||||
| WBStrain00036139 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (129) | |||||||||
| Paralog (44) | |||||||||
| Structured_description | Concise_description | cyp-35A1 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; RT-PCR experiments indicate that cyp-35A1 mRNA is upregulated in response to treatment with xenobiotics, such as PCBs (polychlorinated biphenyls) or PAHs (polycyclic aromatic hydrocarbons); loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds; inaddition, cyp-35A(RNAi) also results in a reduction of fat content. | Paper_evidence | WBPaper00005655 | |||||
| WBPaper00025207 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 26 Feb 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2D6 (cytochrome P450 family 2 subfamily D member 6); and CYP2E1 (cytochrome P450 family 2 subfamily E member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (42) | ||||||||
| Molecular_info | Corresponding_CDS | C03G6.14 | |||||||
| Corresponding_CDS_history | C03G6.14:wp125 | ||||||||
| C03G6.14:wp185 | |||||||||
| C03G6.14:wp261 | |||||||||
| Corresponding_transcript | C03G6.14.1 | ||||||||
| Other_sequence | Dviv_isotig14097 | ||||||||
| Dviv_isotig14098 | |||||||||
| AM743893.1 | |||||||||
| Oden_isotig18384 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00078473 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00078474 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039542 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010067 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114817 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092681 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1017756 | ||||||||
| Expr1143646 | |||||||||
| Expr2010734 | |||||||||
| Drives_construct | WBCnstr00028874 | ||||||||
| Construct_product | WBCnstr00028874 | ||||||||
| Microarray_results (15) | |||||||||
| Expression_cluster (111) | |||||||||
| Interaction | WBInteraction000050752 | ||||||||
| WBInteraction000229386 | |||||||||
| WBInteraction000251744 | |||||||||
| WBInteraction000504567 | |||||||||
| WBInteraction000543107 | |||||||||
| WBInteraction000543110 | |||||||||
| WBInteraction000543111 | |||||||||
| WBInteraction000543113 | |||||||||
| WBInteraction000543115 | |||||||||
| WBInteraction000557186 | |||||||||
| WBInteraction000557195 | |||||||||
| WBInteraction000557204 | |||||||||
| WBInteraction000557264 | |||||||||
| WBInteraction000557273 | |||||||||
| WBInteraction000557282 | |||||||||
| WBInteraction000557291 | |||||||||
| WBInteraction000557300 | |||||||||
| WBInteraction000557309 | |||||||||
| WBInteraction000557318 | |||||||||
| WBInteraction000557327 | |||||||||
| WBInteraction000557336 | |||||||||
| WBInteraction000557345 | |||||||||
| WBInteraction000557354 | |||||||||
| WBInteraction000557363 | |||||||||
| WBInteraction000557374 | |||||||||
| WBInteraction000557383 | |||||||||
| WBInteraction000557392 | |||||||||
| WBInteraction000557437 | |||||||||
| Map_info | Map | V | Position | 0.708623 | Error | 0.002847 | |||
| Positive | Positive_clone | C03G6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5576 | |||||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
