WormBase Tree Display for Gene: WBGene00015135
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WBGene00015135 | SMap | S_parent | Sequence | B0304 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | cyp-23A1 | |||||||
Sequence_name | B0304.3 | ||||||||
Molecular_name | B0304.3 | ||||||||
B0304.3.1 | |||||||||
CE27050 | |||||||||
Other_name | CELE_B0304.3 | Accession_evidence | NDB | BX284602 | |||||
Public_name | cyp-23A1 | ||||||||
DB_info | Database | AceView | gene | 2E805 | |||||
WormQTL | gene | WBGene00015135 | |||||||
WormFlux | gene | WBGene00015135 | |||||||
NDB | locus_tag | CELE_B0304.3 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00015135|UniProtKB=Q27465 | |||||||
family | PTHR24300 | ||||||||
NCBI | gene | 173787 | |||||||
RefSeq | protein | NM_062396.7 | |||||||
TrEMBL | UniProtAcc | Q27465 | |||||||
UniProt_GCRP | UniProtAcc | Q27465 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:30:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 21 Sep 2004 09:38:16 | WBPerson1971 | Name_change | CGC_name | cyp-23A1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | cyp | ||||||||
Allele (55) | |||||||||
Strain | WBStrain00035808 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (15) | |||||||||
Ortholog (57) | |||||||||
Paralog (44) | |||||||||
Structured_description | Concise_description | cyp-23A1 encodes a cytochrome P450 homologous to the human gene CYP7B1, which when mutated leads to giant cell hepatitis (OMIM:231100); as a cytochrome P450, CYP-23A1 is predicted to function as a membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyzes the oxidative metabolism of a variety of exogenous compounds and endogenous substrates. | Paper_evidence | WBPaper00004637 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 20 Nov 2008 00:00:00 | ||||||||
Automated_description | Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in end stage renal disease and renal hypertension. Is an ortholog of human CYP2C8 (cytochrome P450 family 2 subfamily C member 8). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:783 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2622) | ||||
DOID:1073 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2622) | ||||||
Molecular_info | Corresponding_CDS | B0304.3 | |||||||
Corresponding_transcript | B0304.3.1 | ||||||||
Other_sequence (11) | |||||||||
Associated_feature (15) | |||||||||
Experimental_info | RNAi_result | WBRNAi00103146 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00038912 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092638 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00078391 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00009688 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr1028987 | ||||||||
Expr1036472 | |||||||||
Expr1143092 | |||||||||
Expr2010695 | |||||||||
Expr2028934 | |||||||||
Drives_construct | WBCnstr00029059 | ||||||||
Construct_product | WBCnstr00029059 | ||||||||
Microarray_results (19) | |||||||||
Expression_cluster (131) | |||||||||
Interaction | WBInteraction000050741 | ||||||||
WBInteraction000557101 | |||||||||
Map_info | Map | II | Position | -4.29115 | Error | 0.046 | |||
Positive | Positive_clone | B0304 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 5366 | |||||||
Pseudo_map_position | |||||||||
Reference | WBPaper00027704 | ||||||||
WBPaper00038491 | |||||||||
WBPaper00049383 | |||||||||
WBPaper00055090 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |