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WormBase Tree Display for Gene: WBGene00015135

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Name Class

WBGene00015135SMapS_parentSequenceB0304
IdentityVersion2
NameCGC_namecyp-23A1
Sequence_nameB0304.3
Molecular_nameB0304.3
B0304.3.1
CE27050
Other_nameCELE_B0304.3Accession_evidenceNDBBX284602
Public_namecyp-23A1
DB_infoDatabaseAceViewgene2E805
WormQTLgeneWBGene00015135
WormFluxgeneWBGene00015135
NDBlocus_tagCELE_B0304.3
PanthergeneCAEEL|WormBase=WBGene00015135|UniProtKB=Q27465
familyPTHR24300
NCBIgene173787
RefSeqproteinNM_062396.7
TrEMBLUniProtAccQ27465
UniProt_GCRPUniProtAccQ27465
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:30:55WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
221 Sep 2004 09:38:16WBPerson1971Name_changeCGC_namecyp-23A1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcyp
Allele (55)
StrainWBStrain00035808
RNASeq_FPKM (74)
GO_annotation (15)
Ortholog (57)
Paralog (44)
Structured_descriptionConcise_descriptioncyp-23A1 encodes a cytochrome P450 homologous to the human gene CYP7B1, which when mutated leads to giant cell hepatitis (OMIM:231100); as a cytochrome P450, CYP-23A1 is predicted to function as a membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyzes the oxidative metabolism of a variety of exogenous compounds and endogenous substrates.Paper_evidenceWBPaper00004637
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated20 Nov 2008 00:00:00
Automated_descriptionPredicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in end stage renal disease and renal hypertension. Is an ortholog of human CYP2C8 (cytochrome P450 family 2 subfamily C member 8).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:783Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2622)
DOID:1073Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2622)
Molecular_infoCorresponding_CDSB0304.3
Corresponding_transcriptB0304.3.1
Other_sequence (11)
Associated_feature (15)
Experimental_infoRNAi_resultWBRNAi00103146Inferred_automaticallyRNAi_primary
WBRNAi00038912Inferred_automaticallyRNAi_primary
WBRNAi00092638Inferred_automaticallyRNAi_primary
WBRNAi00078391Inferred_automaticallyRNAi_primary
WBRNAi00009688Inferred_automaticallyRNAi_primary
Expr_patternExpr1028987
Expr1036472
Expr1143092
Expr2010695
Expr2028934
Drives_constructWBCnstr00029059
Construct_productWBCnstr00029059
Microarray_results (19)
Expression_cluster (131)
InteractionWBInteraction000050741
WBInteraction000557101
Map_infoMapIIPosition-4.29115Error0.046
PositivePositive_cloneB0304Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5366
Pseudo_map_position
ReferenceWBPaper00027704
WBPaper00038491
WBPaper00049383
WBPaper00055090
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene