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WormBase Tree Display for Gene: WBGene00015135

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WBGene00015135	SMap	S_parent	Sequence	B0304
	Identity	Version	2
		Name	CGC_name	cyp-23A1
			Sequence_name	B0304.3
			Molecular_name	B0304.3
				B0304.3.1
				CE27050
			Other_name	CELE_B0304.3	Accession_evidence	NDB	BX284602
			Public_name	cyp-23A1
		DB_info	Database	AceView	gene	2E805
				WormQTL	gene	WBGene00015135
				WormFlux	gene	WBGene00015135
				NDB	locus_tag	CELE_B0304.3
				Panther	gene	CAEEL\|WormBase=WBGene00015135\|UniProtKB=Q27465
					family	PTHR24300
				NCBI	gene	173787
				RefSeq	protein	NM_062396.7
				TrEMBL	UniProtAcc	Q27465
				UniProt_GCRP	UniProtAcc	Q27465
		Species	Caenorhabditis elegans
		History	Version_change	1	28 May 2004 13:30:55	WBPerson1971	Event	Imported	Initial conversion from CDS class of stlace from WS125
				2	21 Sep 2004 09:38:16	WBPerson1971	Name_change	CGC_name	cyp-23A1
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	cyp
		Allele (55)
		Strain	WBStrain00035808
		RNASeq_FPKM (74)
		GO_annotation (15)
		Ortholog	WBGene00065121	Caenorhabditis remanei	From_analysis	OMA
						TreeFam
						WormBase-Compara
			WBGene00034232	Caenorhabditis briggsae	From_analysis	Hillier-set
						OrthoMCL
						OMA
						WormBase-Compara
			WBGene00154947	Caenorhabditis brenneri	From_analysis	OMA
						TreeFam
						WormBase-Compara
			WBGene00100943	Pristionchus pacificus	From_analysis	OMA
			WBGene00138489	Caenorhabditis japonica	From_analysis	TreeFam
						WormBase-Compara
			WBGene00222012	Brugia malayi	From_analysis	WormBase-Compara
			CBOVI.g7047	Caenorhabditis bovis	From_analysis	WormBase-Compara
			CSP21.g1653	Caenorhabditis parvicauda	From_analysis	WormBase-Compara
			CSP26.g7861	Caenorhabditis zanzibari	From_analysis	WormBase-Compara
			CSP28.g366	Caenorhabditis panamensis	From_analysis	WormBase-Compara
			CSP29.g12711	Caenorhabditis becei	From_analysis	WormBase-Compara
			CSP31.g27470	Caenorhabditis uteleia	From_analysis	WormBase-Compara
			CSP32.g15660	Caenorhabditis sulstoni	From_analysis	WormBase-Compara
			CSP38.g14034	Caenorhabditis quiockensis	From_analysis	WormBase-Compara
			CSP39.g6964	Caenorhabditis waitukubuli	From_analysis	WormBase-Compara
			CSP40.g10147	Caenorhabditis tribulationis	From_analysis	WormBase-Compara
			CSP40.g10148	Caenorhabditis tribulationis	From_analysis	WormBase-Compara
			Cang_2012_03_13_00006.g519	Caenorhabditis angaria	From_analysis	WormBase-Compara
			Cang_2012_03_13_15264.g24981	Caenorhabditis angaria	From_analysis	WormBase-Compara
			Cni-cyp-23A1	Caenorhabditis nigoni	From_analysis	WormBase-Compara
			Csp11.Scaffold570.g4226	Caenorhabditis tropicalis	From_analysis	WormBase-Compara
			Csp5_scaffold_03602.g30703	Caenorhabditis sinica	From_analysis	WormBase-Compara
			FL83_06736	Caenorhabditis latens	From_analysis	WormBase-Compara
			GCK72_004495	Caenorhabditis remanei	From_analysis	WormBase-Compara
			OTIPU.nOt.2.0.1.g02278	Oscheius tipulae	From_analysis	WormBase-Compara
			Pan_g10208	Panagrellus redivivus	From_analysis	WormBase-Compara
			Sp34_20230600	Caenorhabditis inopinata	From_analysis	WormBase-Compara
			chrII_pilon.g4257	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00247570	Onchocerca volvulus	From_analysis	WormBase-Compara
			WBGene00097800	Pristionchus pacificus	From_analysis	WormBase-Compara
			WBGene00265884	Strongyloides ratti	From_analysis	WormBase-Compara
			FB:FBgn0004959	Drosophila melanogaster	From_analysis	Hieranoid
						OrthoFinder
						PhylomeDB
			ZFIN:ZDB-GENE-040426-822	Danio rerio	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
			ZFIN:ZDB-GENE-040426-1571	Danio rerio	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
			HGNC:2622	Homo sapiens	From_analysis	Hieranoid
						OrthoInspector
						Panther
			MGI:105055	Mus musculus	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
						SonicParanoid
			MGI:88596	Mus musculus	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
						SonicParanoid
			MGI:88597	Mus musculus	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
						SonicParanoid
			MGI:88598	Mus musculus	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
						SonicParanoid
			MGI:88599	Mus musculus	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
						SonicParanoid
			MGI:107303	Mus musculus	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
						SonicParanoid
			MGI:88600	Mus musculus	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
						SonicParanoid
			MGI:88602	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OMA
						Panther
						SonicParanoid
			MGI:88606	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OMA
						Panther
						SonicParanoid
			MGI:88608	Mus musculus	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
						SonicParanoid
			MGI:1929474	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OMA
						Panther
						SonicParanoid
			MGI:1923529	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OMA
						Panther
						SonicParanoid
			MGI:2385022	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OMA
						Panther
						SonicParanoid
			MGI:3648316	Mus musculus	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
						SonicParanoid
			MGI:3717097	Mus musculus	From_analysis	Hieranoid
						OMA
						OrthoInspector
						Panther
						SonicParanoid
			MGI:3646735	Mus musculus	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
						SonicParanoid
			MGI:88604	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OMA
						Panther
						SonicParanoid
			MGI:2686296	Mus musculus	From_analysis	Hieranoid
						OMA
						Panther
						PhylomeDB
						SonicParanoid
			MGI:88603	Mus musculus	From_analysis	Hieranoid
						Inparanoid
						OMA
						Panther
						SonicParanoid
			RGD:2472	Rattus norvegicus	From_analysis	Hieranoid
						Inparanoid
						OMA
						OrthoInspector
						Panther
						SonicParanoid
			RGD:2471	Rattus norvegicus	From_analysis	Hieranoid
						Inparanoid
						OMA
						Panther
						SonicParanoid
			RGD:708427	Rattus norvegicus	From_analysis	Hieranoid
						Inparanoid
						OMA
						Panther
						SonicParanoid
		Paralog (44)
		Structured_description	Concise_description	cyp-23A1 encodes a cytochrome P450 homologous to the human gene CYP7B1, which when mutated leads to giant cell hepatitis (OMIM:231100); as a cytochrome P450, CYP-23A1 is predicted to function as a membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyzes the oxidative metabolism of a variety of exogenous compounds and endogenous substrates.	Paper_evidence	WBPaper00004637
					Curator_confirmed	WBPerson1843
						WBPerson567
					Date_last_updated	20 Nov 2008 00:00:00
			Automated_description	Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in end stage renal disease and renal hypertension. Is an ortholog of human CYP2C8 (cytochrome P450 family 2 subfamily C member 8).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:783	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2622)
			DOID:1073	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:2622)
	Molecular_info	Corresponding_CDS	B0304.3
		Corresponding_transcript	B0304.3.1
		Other_sequence (11)
		Associated_feature (15)
	Experimental_info	RNAi_result	WBRNAi00103146	Inferred_automatically	RNAi_primary
			WBRNAi00038912	Inferred_automatically	RNAi_primary
			WBRNAi00092638	Inferred_automatically	RNAi_primary
			WBRNAi00078391	Inferred_automatically	RNAi_primary
			WBRNAi00009688	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr1028987
			Expr1036472
			Expr1143092
			Expr2010695
			Expr2028934
		Drives_construct	WBCnstr00029059
		Construct_product	WBCnstr00029059
		Microarray_results (19)
		Expression_cluster (131)
		Interaction	WBInteraction000050741
			WBInteraction000557101
	Map_info	Map	II	Position	-4.29115	Error	0.046
		Positive	Positive_clone	B0304	Inferred_automatically	From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	5366
		Pseudo_map_position
	Reference	WBPaper00027704
		WBPaper00038491
		WBPaper00049383
		WBPaper00055090
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene