WormBase Tree Display for Gene: WBGene00014092

WBGene00014092 SMap: S_parent: Sequence: ZK822
  Identity: Version: 2
    Name: CGC_name: slc-5A12 Author_evidence: WBPerson555
      Sequence_name: ZK822.5
      Molecular_name: ZK822.5
        ZK822.5.1
        CE18466
      Other_name: CELE_ZK822.5 Accession_evidence: NDB BX284604
      Public_name: slc-5A12
    DB_info: Database: AceView gene 4M703
        WormQTL gene WBGene00014092
        WormFlux gene WBGene00014092
        NDB locus_tag CELE_ZK822.5
        Panther gene CAEEL|WormBase=WBGene00014092|UniProtKB=Q23616
          family PTHR42985
        NCBI gene 178127
        RefSeq protein NM_001047602.6
        TrEMBL UniProtAcc Q23616
        UniProt_GCRP UniProtAcc Q23616
        OMIM gene 601843
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:55 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 10 Jul 2023 23:47:10 WBPerson51134 Name_change: CGC_name: slc-5A12
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: slc
    Allele (41)
    Strain: WBStrain00001221
      WBStrain00032464
    RNASeq_FPKM (74)
    GO_annotation: 00057527
      00057528
      00057529
      00057530
      00057531
      00057532
      00120820
      00120821
      00120822
    Ortholog (65)
    Paralog: WBGene00018716 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000501 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Expressed in several structures, including intestine; nervous system; non-striated muscle; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 1. Is an ortholog of human SLC5A12 (solute carrier family 5 member 12) and SLC5A8 (solute carrier family 5 member 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0112185 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11040)
      DOID:0050328 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11040)
  Molecular_info: Corresponding_CDS: ZK822.5
    Corresponding_CDS_history: ZK822.5b:wp288
    Corresponding_transcript: ZK822.5.1
    Other_sequence (23)
    Associated_feature: WBsf646436
      WBsf660772
      WBsf997993
      WBsf229223
  Experimental_info: RNAi_result: WBRNAi00081182 Inferred_automatically: RNAi_primary
      WBRNAi00022181 Inferred_automatically: RNAi_primary
      WBRNAi00059746 Inferred_automatically: RNAi_primary
      WBRNAi00038452 Inferred_automatically: RNAi_primary
      WBRNAi00059745 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1396
      Expr7257
      Expr7258
      Expr1019115
      Expr1036312
      Expr1163169
      Expr2008982
      Expr2027218
    Drives_construct: WBCnstr00002114
      WBCnstr00004223
      WBCnstr00029316
    Construct_product: WBCnstr00029316
    Microarray_results (27)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00037950:bodywall-muscle_embryo_enriched
      WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Spermatogenic
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00046499:AMPK_regulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048923:Aging_regulated
      WBPaper00048952:glucose_induced
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049905:Age_variant_expression
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:lin-15B(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055364:uaf-1(n4588)_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055897:heat-shock_downregulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00057158:mdt-15(tm2182)_dependent_15C_upregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059598:HeatShock_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059895:wounding_downregulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00060921:tdc-1(n3419)_downregulated
      WBPaper00061007:HB115_downregulated
      WBPaper00061007:M.braciatum_downregulated
      WBPaper00061040:eat-2(ad1116)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:nhr-107_19485-nhr-109_3743
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064502:nhr-23(kry61);spe-44(fx110)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065288:mdt-15(tm2182)_downregulated
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:4_0
      WBPaper00065841:4_1
      WBPaper00065841:4_2
      WBPaper00065841:38_2
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      cgc4489_group_17
      cgc4489_group_25
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00034739:N2moreDR1350
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_C
      WBPaper00040210:Chlorpyrifos_16C_regulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00049311:AgNO3_regulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc6390]:male_soma-enriched
    Interaction (15)
  Map_info: Map: IV Position: 5.43389
    Positive: Positive_clone: ZK822 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00034662
    WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene