WormBase Tree Display for Gene: WBGene00011734
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| WBGene00011734 | SMap | S_parent | Sequence | T12D8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mlc-5 | Paper_evidence | WBPaper00035085 | |||||
| Person_evidence | WBPerson21 | ||||||||
| Sequence_name | T12D8.6 | ||||||||
| Molecular_name | T12D8.6 | ||||||||
| T12D8.6.1 | |||||||||
| CE16403 | |||||||||
| Other_name | CELE_T12D8.6 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | mlc-5 | ||||||||
| DB_info | Database | AceView | gene | 3O713 | |||||
| WormQTL | gene | WBGene00011734 | |||||||
| WormFlux | gene | WBGene00011734 | |||||||
| NDB | locus_tag | CELE_T12D8.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00011734|UniProtKB=Q9XVI9 | |||||||
| family | PTHR23048 | ||||||||
| NCBI | gene | 176796 | |||||||
| RefSeq | protein | NM_067412.10 | |||||||
| SwissProt | UniProtAcc | Q9XVI9 | |||||||
| UniProt_GCRP | UniProtAcc | Q9XVI9 | |||||||
| OMIM | gene | 160770 | |||||||
| 160780 | |||||||||
| 160790 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:52 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 26 Jul 2011 11:53:04 | WBPerson2970 | Name_change | CGC_name | mlc-5 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mlc | ||||||||
| Allele (23) | |||||||||
| Strain | WBStrain00003504 | ||||||||
| WBStrain00049410 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Contained_in_operon | CEOP3816 | ||||||||
| Ortholog (61) | |||||||||
| Paralog | WBGene00003371 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00009585 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00010554 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00023451 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mlc-5 encodes a protein containing two EF-hand domains that is the C. elegans myosin II essential light chain ortholog; MLC-5 activity is required for cytokinesis and for epithelial morphogenesis during embryonic elongation; a GFP::MLC-5 fusion protein is expressed during embryogenesis in the lateral hypodermal seam cells as well as in the dorsal and ventral hypodermal cells where it exhibits co-localization with actin bundles; MLC-5 subcellular localization depends upon activity of MLC-4, a myosin regulatory light chain; in turn, MLC-5 activity is required for proper localization of MLC-4 and the non-muscle myosin II NMY-2. | Paper_evidence | WBPaper00035085 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 06 Sep 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable calcium ion binding activity. Involved in mitotic cytokinesis. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in congenital myopathy 14; familial atrial fibrillation; and hypertrophic cardiomyopathy 8. Is an ortholog of human MYL4 (myosin light chain 4); MYL6 (myosin light chain 6); and MYL6B (myosin light chain 6B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0081346 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7582) | ||||
| DOID:0050650 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7585) | ||||||
| DOID:0050700 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7585) | ||||||
| DOID:0110314 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7584) | ||||||
| Molecular_info | Corresponding_CDS | T12D8.6 | |||||||
| Corresponding_transcript | T12D8.6.1 | ||||||||
| Other_sequence (97) | |||||||||
| Associated_feature | WBsf645723 | ||||||||
| WBsf645724 | |||||||||
| WBsf654994 | |||||||||
| WBsf226038 | |||||||||
| WBsf226039 | |||||||||
| WBsf226040 | |||||||||
| WBsf226041 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Chronogram448 | ||||||||
| Expr6682 | |||||||||
| Expr1017597 | |||||||||
| Expr1035159 | |||||||||
| Expr1156796 | |||||||||
| Expr2013593 | |||||||||
| Expr2031826 | |||||||||
| Drives_construct | WBCnstr00003962 | ||||||||
| WBCnstr00030430 | |||||||||
| Construct_product | WBCnstr00030430 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (110) | |||||||||
| Interaction (28) | |||||||||
| Map_info | Map | III | Position | 21.2981 | Error | 0.001406 | |||
| Positive | Positive_clone | T12D8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00024200 | ||||||||
| WBPaper00035085 | |||||||||
| WBPaper00035228 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040157 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
