WormBase Tree Display for Gene: WBGene00011734
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WBGene00011734 | SMap | S_parent | Sequence | T12D8 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | mlc | ||||||
Allele (23) | |||||||
Strain | WBStrain00003504 | ||||||
WBStrain00049410 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (11) | |||||||
Contained_in_operon | CEOP3816 | ||||||
Ortholog (61) | |||||||
Paralog | WBGene00003371 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00009585 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00010554 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00023451 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | mlc-5 encodes a protein containing two EF-hand domains that is the C. elegans myosin II essential light chain ortholog; MLC-5 activity is required for cytokinesis and for epithelial morphogenesis during embryonic elongation; a GFP::MLC-5 fusion protein is expressed during embryogenesis in the lateral hypodermal seam cells as well as in the dorsal and ventral hypodermal cells where it exhibits co-localization with actin bundles; MLC-5 subcellular localization depends upon activity of MLC-4, a myosin regulatory light chain; in turn, MLC-5 activity is required for proper localization of MLC-4 and the non-muscle myosin II NMY-2. | Paper_evidence | WBPaper00035085 | |||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 06 Sep 2011 00:00:00 | ||||||
Automated_description | Predicted to enable calcium ion binding activity. Involved in mitotic cytokinesis. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in congenital myopathy 14; familial atrial fibrillation; and hypertrophic cardiomyopathy 8. Is an ortholog of human MYL4 (myosin light chain 4); MYL6 (myosin light chain 6); and MYL6B (myosin light chain 6B). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0081346 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7582) | ||
DOID:0050650 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7585) | ||||
DOID:0050700 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7585) | ||||
DOID:0110314 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7584) | ||||
Molecular_info | Corresponding_CDS | T12D8.6 | |||||
Corresponding_transcript | T12D8.6.1 | ||||||
Other_sequence (97) | |||||||
Associated_feature | WBsf645723 | ||||||
WBsf645724 | |||||||
WBsf654994 | |||||||
WBsf226038 | |||||||
WBsf226039 | |||||||
WBsf226040 | |||||||
WBsf226041 | |||||||
Experimental_info | RNAi_result (11) | ||||||
Expr_pattern | Chronogram448 | ||||||
Expr6682 | |||||||
Expr1017597 | |||||||
Expr1035159 | |||||||
Expr1156796 | |||||||
Expr2013593 | |||||||
Expr2031826 | |||||||
Drives_construct | WBCnstr00003962 | ||||||
WBCnstr00030430 | |||||||
Construct_product | WBCnstr00030430 | ||||||
Microarray_results (21) | |||||||
Expression_cluster (110) | |||||||
Interaction (28) | |||||||
Map_info | Map | III | Position | 21.2981 | Error | 0.001406 | |
Positive | Positive_clone | T12D8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00024200 | ||||||
WBPaper00035085 | |||||||
WBPaper00035228 | |||||||
WBPaper00038491 | |||||||
WBPaper00040157 | |||||||
WBPaper00055090 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |