WormBase Tree Display for Gene: WBGene00010890
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| WBGene00010890 | SMap | S_parent | Sequence | M18 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ddb-1 | Person_evidence | WBPerson322 | |||||
| Sequence_name | M18.5 | ||||||||
| Molecular_name | M18.5 | ||||||||
| M18.5.1 | |||||||||
| CE23880 | |||||||||
| Other_name | CELE_M18.5 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | ddb-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:51 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 02 Feb 2006 09:28:57 | WBPerson2970 | Name_change | CGC_name | ddb-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ddb | ||||||||
| Allele (75) | |||||||||
| Possibly_affected_by | WBVar02152930 | ||||||||
| Strain | WBStrain00007247 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00019323 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00022301 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ddb-1 encodes a protein orthologous to human DNA damage-binding protein 1 (DDB1); ddb-1 is part of a ubiquitin ligase E3 complex, CUL-4/DDB-1, and targets the replication licensing factor, cdt-1, for ubiquitin-mediated proteolysis; ddb-1 interacts physically with CUL-4/Cullin and CDT-1; the CUL-4/DDB-1 complex also regulates SKN-1 transcription factor activity, and LET-23/EGFR signalling in vulval precursor cells. | Paper_evidence | WBPaper00028868 | |||||
| WBPaper00037735 | |||||||||
| WBPaper00032980 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 07 May 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm; nucleus; and site of double-strand break. Expressed in several structures, including P1.p; P2.p; P5.ppp; P7.paa; and rectum. Used to study xeroderma pigmentosum. Is an ortholog of human DDB1 (damage specific DNA binding protein 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0050427 | Homo sapiens | Paper_evidence | WBPaper00028868 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 13 Mar 2023 00:00:00 | ||||||||
| Potential_model | DOID:2033 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2717) | |||||
| Disease_relevance | The human DNA damage-binding protein 1 (DDB1; orthologous to elegans ddb-1) is required for ultraviolet light-damaged DNA repair and binds to DDB2 to form a DNA-binding protein complex (the UV-DDB complex); mutations in DDB1 have been linked to Xeroderma pigmentosum. | Homo sapiens | Accession_evidence | OMIM | 600045 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 07 May 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000174 | ||||||||
| Molecular_info | Corresponding_CDS | M18.5 | |||||||
| Corresponding_transcript | M18.5.1 | ||||||||
| Other_sequence (25) | |||||||||
| Associated_feature | WBsf652277 | ||||||||
| WBsf668398 | |||||||||
| WBsf998029 | |||||||||
| WBsf1018324 | |||||||||
| WBsf1018325 | |||||||||
| WBsf230968 | |||||||||
| WBsf230969 | |||||||||
| WBsf230970 | |||||||||
| Experimental_info | RNAi_result (20) | ||||||||
| Expr_pattern | Expr8280 | ||||||||
| Expr14902 | |||||||||
| Expr1022821 | |||||||||
| Expr1034774 | |||||||||
| Expr1154715 | |||||||||
| Expr2010823 | |||||||||
| Expr2029061 | |||||||||
| Drives_construct | WBCnstr00013235 | ||||||||
| WBCnstr00031076 | |||||||||
| Construct_product | WBCnstr00013235 | ||||||||
| WBCnstr00031076 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (108) | |||||||||
| Interaction (106) | |||||||||
| Map_info | Map | IV | Position | 5.7211 | Error | 0.003923 | |||
| Positive | Positive_clone | M18 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
