WormBase Tree Display for Gene: WBGene00010890
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WBGene00010890 | SMap | S_parent | Sequence | M18 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ddb | ||||||
Allele (75) | |||||||
Possibly_affected_by | WBVar02152930 | ||||||
Strain | WBStrain00007247 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (21) | |||||||
Ortholog (38) | |||||||
Paralog | WBGene00019323 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00022301 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | ddb-1 encodes a protein orthologous to human DNA damage-binding protein 1 (DDB1); ddb-1 is part of a ubiquitin ligase E3 complex, CUL-4/DDB-1, and targets the replication licensing factor, cdt-1, for ubiquitin-mediated proteolysis; ddb-1 interacts physically with CUL-4/Cullin and CDT-1; the CUL-4/DDB-1 complex also regulates SKN-1 transcription factor activity, and LET-23/EGFR signalling in vulval precursor cells. | Paper_evidence | WBPaper00028868 | |||
WBPaper00037735 | |||||||
WBPaper00032980 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson324 | |||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 07 May 2013 00:00:00 | ||||||
Automated_description | Predicted to enable DNA binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm; nucleus; and site of double-strand break. Expressed in several structures, including P1.p; P2.p; P5.ppp; P7.paa; and rectum. Used to study xeroderma pigmentosum. Is an ortholog of human DDB1 (damage specific DNA binding protein 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:0050427 | Homo sapiens | Paper_evidence | WBPaper00028868 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 13 Mar 2023 00:00:00 | ||||||
Potential_model | DOID:2033 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2717) | |||
Disease_relevance | The human DNA damage-binding protein 1 (DDB1; orthologous to elegans ddb-1) is required for ultraviolet light-damaged DNA repair and binds to DDB2 to form a DNA-binding protein complex (the UV-DDB complex); mutations in DDB1 have been linked to Xeroderma pigmentosum. | Homo sapiens | Accession_evidence | OMIM | 600045 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 07 May 2013 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000174 | ||||||
Molecular_info | Corresponding_CDS | M18.5 | |||||
Corresponding_transcript | M18.5.1 | ||||||
Other_sequence (25) | |||||||
Associated_feature | WBsf652277 | ||||||
WBsf668398 | |||||||
WBsf998029 | |||||||
WBsf1018324 | |||||||
WBsf1018325 | |||||||
WBsf230968 | |||||||
WBsf230969 | |||||||
WBsf230970 | |||||||
Experimental_info | RNAi_result (20) | ||||||
Expr_pattern | Expr8280 | ||||||
Expr14902 | |||||||
Expr1022821 | |||||||
Expr1034774 | |||||||
Expr1154715 | |||||||
Expr2010823 | |||||||
Expr2029061 | |||||||
Drives_construct | WBCnstr00013235 | ||||||
WBCnstr00031076 | |||||||
Construct_product | WBCnstr00013235 | ||||||
WBCnstr00031076 | |||||||
Microarray_results (18) | |||||||
Expression_cluster (108) | |||||||
Interaction (106) | |||||||
Map_info | Map | IV | Position | 5.7211 | Error | 0.003923 | |
Positive | Positive_clone | M18 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (20) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |