WormBase Tree Display for Gene: WBGene00010705

WBGene00010705 SMap: S_parent: Sequence: K09A11
  Identity: Version: 2
    Name: CGC_name: cyp-14A1
      Sequence_name: K09A11.2
      Molecular_name: K09A11.2
        K09A11.2.1
        CE03473
      Other_name: CELE_K09A11.2 Accession_evidence: NDB BX284606
      Public_name: cyp-14A1
    DB_info: Database: AceView gene XN884
        WormQTL gene WBGene00010705
        WormFlux gene WBGene00010705
        NDB locus_tag CELE_K09A11.2
        Panther gene CAEEL|WormBase=WBGene00010705|UniProtKB=Q27506
          family PTHR24284
        NCBI gene 187183
        RefSeq protein NM_077802.5
        TrEMBL UniProtAcc Q27506
        UniProt_GCRP UniProtAcc Q27506
        OMIM gene 610670
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-14A1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (45)
    RNASeq_FPKM (74)
    GO_annotation: 00079911
      00079912
      00079913
      00079914
      00118047
      00118048
      00118049
      00118050
    Ortholog (55)
    Paralog (42)
    Structured_description: Concise_description: cyp-14A1 encodes one of ~80 C. elegans cytochrome P450s: membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyze the oxidative metabolism of a variety of exogenous compounds and endogenous substrates. Curator_confirmed: WBPerson1843
          Date_last_updated: 20 Nov 2008 00:00:00
      Automated_description: Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; hematologic cancer (multiple); and hereditary spastic paraplegia 56. Is an ortholog of several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); and CYP2W1 (cytochrome P450 family 2 subfamily W member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (12)
  Molecular_info: Corresponding_CDS: K09A11.2
    Corresponding_transcript: K09A11.2.1
    Other_sequence: EY468469.1
      PPC09763_1
    Associated_feature: WBsf982263
      WBsf238117
  Experimental_info: RNAi_result: WBRNAi00050360 Inferred_automatically: RNAi_primary
      WBRNAi00034174 Inferred_automatically: RNAi_primary
      WBRNAi00092632 Inferred_automatically: RNAi_primary
      WBRNAi00116299 Inferred_automatically: RNAi_primary
      WBRNAi00016859 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1015287
      Expr1154065
      Expr2010691
      Expr2028930
    Drives_construct: WBCnstr00031204
    Construct_product: WBCnstr00031204
    Microarray_results (18)
    Expression_cluster (188)
    Interaction: WBInteraction000155640
      WBInteraction000156224
  Map_info: Map: X Position: 11.0455
    Positive: Positive_clone: K09A11 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00063971
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene