WormBase Tree Display for Gene: WBGene00010659

WBGene00010659 SMap: S_parent: Sequence: K08D8
  Identity: Version: 1
    Name: Sequence_name: K08D8.5
      Molecular_name: K08D8.5
        K08D8.5.1
        CE06144
      Other_name: CELE_K08D8.5 Accession_evidence: NDB BX284604
      Public_name: K08D8.5
    DB_info: Database: AceView gene 4N676
        WormQTL gene WBGene00010659
        WormFlux gene WBGene00010659
        NDB locus_tag CELE_K08D8.5
        Panther gene CAEEL|WormBase=WBGene00010659|UniProtKB=Q21327
          family PTHR47919
        NCBI gene 178243
        RefSeq protein NM_070061.5
        TREEFAM TREEFAM_ID TF316078
        TrEMBL UniProtAcc Q21327
        UniProt_GCRP UniProtAcc Q21327
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
    Status: Live
  Gene_info: Biotype: SO:0001217
    Allele: WBVar01500079
      WBVar01954302
      WBVar01498996
      WBVar01570523
      WBVar01499925
      WBVar00261719
      WBVar00192873
      WBVar00192874
      WBVar01804152
      WBVar01804153
      WBVar01804154
      WBVar01804155
      WBVar00438724
      WBVar00438725
      WBVar00438726
      WBVar00438727
      WBVar00438728
      WBVar00091023
      WBVar00951179
      WBVar00951180
      WBVar00951181
      WBVar01499492
      WBVar00951182
      WBVar00951183
      WBVar01499493
      WBVar00951184
      WBVar00951185
      WBVar00951186
      WBVar00951187
      WBVar00951188
      WBVar00951189
      WBVar01500245
    RNASeq_FPKM (74)
    GO_annotation: 00071299
      00071300
    Ortholog (33)
    Paralog (35)
    Structured_description: Concise_description: K08D8.5 encodes a CUB-like domain-containing protein; K08D8.5 is involved in the transcriptional, innate immune response towards several different bacterial pathogens; K08D8.5 expression is also induced in response to stressors such as ionizing radiation. Paper_evidence: WBPaper00028482
            WBPaper00032454
            WBPaper00041211
          Curator_confirmed: WBPerson1843
          Date_last_updated: 19 Feb 2014 00:00:00
      Automated_description: Involved in innate immune response and response to gamma radiation. Expressed in head neurons; intestine; and rectal gland cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: K08D8.5
    Corresponding_transcript: K08D8.5.1
    Associated_feature: WBsf231067
  Experimental_info: RNAi_result: WBRNAi00098166 Inferred_automatically: RNAi_primary
      WBRNAi00075961 Inferred_automatically: RNAi_primary
      WBRNAi00095215 Inferred_automatically: RNAi_primary
      WBRNAi00050273 Inferred_automatically: RNAi_primary
      WBRNAi00016798 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4730
      Expr1022623
      Expr1153972
      Expr2004915
      Expr2023137
    Drives_construct: WBCnstr00012207
      WBCnstr00015894
      WBCnstr00031247
    Construct_product: WBCnstr00012207
      WBCnstr00031247
    Microarray_results (23)
    Expression_cluster: WBPaper00024375:Up_N2_vs_vhl-1
      WBPaper00027339:daf-12(rh273)_downregulated
      WBPaper00031040:Cluster_4
      WBPaper00032022:X-Ray_upregulated
      WBPaper00032454:IR_upregulated
      WBPaper00036291:ung-1_regulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00040412:germline-regulated_daf-16_target
      WBPaper00042215:wdr-23(tm1817)_downregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_2.0uM_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00045401:N.parisii_40h_downregulated
      WBPaper00045401:N.parisii_64h_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:lin-35(n745)_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048530:fshr-1(ok778)_PA14_upregulated
      WBPaper00048952:glucose_repressed
      WBPaper00049217:TCER-1_upregulated
      WBPaper00049266:NaAsO2-Stress_regulated_N2
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049484:elt-2(RNAi)_downregulated_L4
      WBPaper00049498:npr-1(ur89)_regulated_5
      WBPaper00049920:hyl-2(tm2031)_upregulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050096:P.aeruginosa_upregulated
      WBPaper00050121:mir-60(n4947)_downregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050193:met-2(n4256)set-25(n5021)_downregulated_L1
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:ash-2(RNAi)_regulated_intestine
      WBPaper00051039:intestine_enriched
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054758:alg-1(gk204)_downregulated
      WBPaper00054810:deoxynivalenol_upregulated
      WBPaper00054872:egl-9(sa307)_upregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055060:flr-1(RNAi)_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055386:daf-2(e1370)_downregulated
      WBPaper00055386:eat-2(ad465)_upregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055648:male-vas-deferens_expressed
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056034:pals-25(jy9)_downregulated
      WBPaper00056039:ptl-1(ok621)_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_adult
      WBPaper00056169:rrf-3(pk1426)_upregulated_L3
      WBPaper00056169:rrf-3(pk1426)_upregulated_L4
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056586:kri-1(ok1251);mpk-2(ok219)_downregulated
      WBPaper00056586:kri-1(ok1251)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated
      WBPaper00057265:metaformin_downregulated_OP50
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059253:stearic-acid_upregulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059426:SiO2-nanoparticles_downregulated
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059735:glucose_downregulated_N2
      WBPaper00059739:hira-1(gk835598)_upregulated_L1
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:CoCl2_6hr_upregulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060634:fhod-1(tm2363)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060703:nas-38(ok3407)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:HB115_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061081:E.faecalis_downregulated_N2
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061319:pnp-1(jy90)_upregulated
      WBPaper00061319:pnp-1(jy121)_upregulated
      WBPaper00061340:AVD
      WBPaper00061340:Z1_Z4
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061466:nath-10(icb102)_upregulated
      WBPaper00061527:C17H12.6-swt-6
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061800:miR-85(n4117)_downregulated_20C
      WBPaper00061823:mex-3(spr9)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062440:crh-1(syb385)_upregulated
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064532:pals-22(jy3)_downregulated
      WBPaper00064632:daf-2(e1370)_downregulated_intestine
      WBPaper00064661:lpd-3(ok2138)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064728:cpl-1(W32AY35A)_upregulated
      WBPaper00064762:freezing-thaw_regulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065005:sams-3(RNAi)_upregulated
      WBPaper00065005:sams-4(RNAi)_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065392:Lb.delbrueckii_downregulated
      WBPaper00065392:Lb.gasseri_downregulated
      WBPaper00065392:Lb.plantarum_downregulated
      WBPaper00065392:Lb.reuteri_downregulated
      WBPaper00065392:Lb.rhamnosus_downregulated
      WBPaper00065392:P.pentosaceus_downregulated
      WBPaper00065581:hpk-1(pk1393)_downregulated
      WBPaper00065746:eat-2(ad1113)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065823:pmk-1(km25)_downregulated
      WBPaper00065835:Day5_vs_Day1_upregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:3_1
      WBPaper00065841:3_2
      WBPaper00065841:3_5
      WBPaper00065841:30_3
      WBPaper00065841:57_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066004:ceh-14(ch3)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4489_group_11
      WBPaper00005475:Aging-regulated
      WBPaper00025099:MA_specific
      WBPaper00028482:PA14_upregulated
      WBPaper00028789:PA14_vs_gacA_upregulated_4hr
      WBPaper00028789:PA14_vs_OP50_upregulated_4hr
      WBPaper00028789:PA14_vs_OP50_upregulated_8hr
      WBPaper00028789:pmk-1_upregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00029437:rde-4_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031850:mdt-15(RNAi)_upregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00035892:KIM5_vs_OP50_Up
      WBPaper00035892:Y.pestis_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_D
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00038462:aging_downregulated
      WBPaper00039851:HK_C_albicans_vs_HK_OP50
      WBPaper00039851:Live_C_albicans_vs_HK_OP50
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.5
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041211:RPW-24_Up
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00042128:gei-8(ok1671)_upregulated
      WBPaper00042204:Comamonas_DA1877_upregulated
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00042258:DA1877_upregulated_YoungAdult
      WBPaper00042258:HT115_upregulated_YoungAdult
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00047070:DAF-16-dependent_UV_response
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048929:ethosuximide_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00050515:pmk-1(km25)_downregulated
      WBPaper00050767:Octopamine_induced
      WBPaper00053550:daf-19(m86)_downregulated_AdultDay2
      WBPaper00055899:2,4-Dinitroanisole_regulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5976]:class_2
      [cgc6390]:male_sex-enriched
    Interaction (16)
  Map_info: Positive: Positive_clone: K08D8 Inferred_automatically: From sequence, transcript, pseudogene data
    Interpolated_map_position: IV 6.46043
  Reference: WBPaper00028789
    WBPaper00029438
    WBPaper00032331
    WBPaper00032454
    WBPaper00035891
    WBPaper00041211
    WBPaper00047109
    WBPaper00061133
    WBPaper00065625
    WBPaper00066012
  Method: Gene