K04C1.2 encodes a protein most closely related to the C. elegans SOP-2 Polycomb group protein; the product of K04C1.2 contains, at its C terminus, a region that has similarity to the SAM (sterile alpha motif) domain, an evolutionarily conserved protein-protein interaction domain of approximately 70 amino acids; although the similarity between SOP-2 and K04C1.2 extends through the SAM domain, replacement of the SOP-2 SAM domain with that of K04C1.2 leads to aberrant localization of the chimeric protein, illustrating that the two SAM domains are not functionally conserved.
Enriched in several structures, including ABalaaaarl; ABalaaaarr; ABplpaaaap; PVR; and mechanosensory neurons based on microarray; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-2; sir-2.1; and pgl-1 based on microarray and RNA-seq studies. Is affected by four chemicals including Zidovudine; paraquat; and Chlorpyrifos based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domain: Sterile alpha motif/pointed domain superfamily.