WormBase Tree Display for Gene: WBGene00004945
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| WBGene00004945 | Evidence | Person_evidence | WBPerson160 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_II | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | sop-2 | Person_evidence | WBPerson160 | |||||
| Sequence_name | C50E10.4 | ||||||||
| Molecular_name | C50E10.4a | ||||||||
| C50E10.4a.1 | |||||||||
| CE32334 | |||||||||
| C50E10.4b | |||||||||
| CE47166 | |||||||||
| C50E10.4c | |||||||||
| CE47133 | |||||||||
| C50E10.4b.1 | |||||||||
| C50E10.4c.1 | |||||||||
| Other_name | CELE_C50E10.4 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | sop-2 | ||||||||
| DB_info | Database | AceView | gene | 2M633 | |||||
| WormQTL | gene | WBGene00004945 | |||||||
| WormFlux | gene | WBGene00004945 | |||||||
| NDB | locus_tag | CELE_C50E10.4 | |||||||
| NCBI | gene | 174874 | |||||||
| RefSeq | protein | NM_001267413.3 | |||||||
| NM_001267412.2 | |||||||||
| NM_001267411.2 | |||||||||
| SwissProt | UniProtAcc | Q965H3 | |||||||
| TrEMBL | UniProtAcc | H8P172 | |||||||
| H8P173 | |||||||||
| UniProt_GCRP | UniProtAcc | Q965H3 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sop | ||||||||
| Allele (141) | |||||||||
| Strain | WBStrain00036186 | ||||||||
| WBStrain00007188 | |||||||||
| WBStrain00008579 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog | WBGene00070774 | Caenorhabditis remanei | From_analysis | OMA | |||||
| WBGene00060128 | Caenorhabditis remanei | From_analysis | Inparanoid_8 | ||||||
| Sp34_20051800 | Caenorhabditis inopinata | From_analysis | WormBase-Compara | ||||||
| chrII_pilon.g6141 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00125506 | Caenorhabditis japonica | From_analysis | WormBase-Compara | ||||||
| Paralog | WBGene00010552 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sop-2 encodes a SAM domain-containing protein that is related to, but not orthologous with, Polycomb group proteins and ETS transcription factors; during development, SOP-2 activity is required for the proper integration of sexual, spatial, and temporal information during cell fate specification; specifically, SOP-2 is required for maintaining a restricted pattern of Hox gene expression, such as that of mab-5 and egl-5, to specific cells and tissues such as the serotonergic and dopaminergic male tail neurons and the ventral nerve cord; in addition, SOP-2 is required for the proper sexual and temporal specification of the hypodermal seam cells; in regulating temporal fate specification, genetic analyses indicate that sop-2 acts upstream of lin-29 in the heterochronic pathway and interacts with other members of the heterochronic pathway, such as lin-4, let-7, and hbl-1, to integrate temporal information and cell fate specification; sop-2 mutations also result in an increase in ALG-1-containing P bodies in hypodermal seam cells; in regulating neurotransmitter phenotype, sop-2 functions together with sor-3, which also encodes a Polycomb group protein, and members of the TGF-beta signaling pathway; sop-2 and sor-3 also function together to regulate progression through larval development; a SOP-2::GFP reporter fusion is expressed in the nuclei of all somatic cells beginning at the 50-cell stage of embryogenesis; SOP-2::GFP expression is initially diffuse, but by the 200-cell stage is visible in distinct nuclear bodies, the size and number of which may correlate with DNA content. | Paper_evidence | WBPaper00005924 | |||||
| WBPaper00024202 | |||||||||
| WBPaper00028988 | |||||||||
| WBPaper00031488 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 08 Aug 2008 00:00:00 | ||||||||
| Automated_description | Enables RNA binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of cytoplasmic mRNA processing body assembly; neuron differentiation; and regulation of gene expression. Located in nuclear speck. Expressed widely. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C50E10.4a | |||||||
| C50E10.4b | |||||||||
| C50E10.4c | |||||||||
| Corresponding_CDS_history | C50E10.4:wp89 | ||||||||
| Corresponding_transcript | C50E10.4a.1 | ||||||||
| C50E10.4b.1 | |||||||||
| C50E10.4c.1 | |||||||||
| Associated_feature | WBsf981311 | ||||||||
| WBsf990051 | |||||||||
| WBsf990052 | |||||||||
| WBsf990053 | |||||||||
| WBsf1013409 | |||||||||
| WBsf1013410 | |||||||||
| WBsf1013411 | |||||||||
| WBsf222260 | |||||||||
| WBsf222261 | |||||||||
| Transcription_factor | WBTranscriptionFactor000203 | ||||||||
| Experimental_info | RNAi_result (21) | ||||||||
| Expr_pattern | Expr2597 | ||||||||
| Expr12241 | |||||||||
| Expr1025868 | |||||||||
| Expr1032460 | |||||||||
| Expr1146873 | |||||||||
| Expr2016005 | |||||||||
| Expr2034240 | |||||||||
| Drives_construct | WBCnstr00000173 | ||||||||
| WBCnstr00000174 | |||||||||
| WBCnstr00035311 | |||||||||
| Construct_product | WBCnstr00035311 | ||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (128) | |||||||||
| Interaction (55) | |||||||||
| Map_info | Map | II | Position | 8.55189 | Error | 0.18042 | |||
| Positive | Positive_clone | C50E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4624 | |||||||
| 4686 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (28) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
