WormBase Tree Display for Gene: WBGene00004945
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WBGene00004945 | Evidence | Person_evidence | WBPerson160 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_II | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | sop | ||||||
Allele (141) | |||||||
Strain | WBStrain00036186 | ||||||
WBStrain00007188 | |||||||
WBStrain00008579 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (32) | |||||||
Ortholog | WBGene00070774 | Caenorhabditis remanei | From_analysis | OMA | |||
WBGene00060128 | Caenorhabditis remanei | From_analysis | Inparanoid_8 | ||||
Sp34_20051800 | Caenorhabditis inopinata | From_analysis | WormBase-Compara | ||||
chrII_pilon.g6141 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00125506 | Caenorhabditis japonica | From_analysis | WormBase-Compara | ||||
Paralog | WBGene00010552 | Caenorhabditis elegans | From_analysis | TreeFam | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | sop-2 encodes a SAM domain-containing protein that is related to, but not orthologous with, Polycomb group proteins and ETS transcription factors; during development, SOP-2 activity is required for the proper integration of sexual, spatial, and temporal information during cell fate specification; specifically, SOP-2 is required for maintaining a restricted pattern of Hox gene expression, such as that of mab-5 and egl-5, to specific cells and tissues such as the serotonergic and dopaminergic male tail neurons and the ventral nerve cord; in addition, SOP-2 is required for the proper sexual and temporal specification of the hypodermal seam cells; in regulating temporal fate specification, genetic analyses indicate that sop-2 acts upstream of lin-29 in the heterochronic pathway and interacts with other members of the heterochronic pathway, such as lin-4, let-7, and hbl-1, to integrate temporal information and cell fate specification; sop-2 mutations also result in an increase in ALG-1-containing P bodies in hypodermal seam cells; in regulating neurotransmitter phenotype, sop-2 functions together with sor-3, which also encodes a Polycomb group protein, and members of the TGF-beta signaling pathway; sop-2 and sor-3 also function together to regulate progression through larval development; a SOP-2::GFP reporter fusion is expressed in the nuclei of all somatic cells beginning at the 50-cell stage of embryogenesis; SOP-2::GFP expression is initially diffuse, but by the 200-cell stage is visible in distinct nuclear bodies, the size and number of which may correlate with DNA content. | Paper_evidence | WBPaper00005924 | |||
WBPaper00024202 | |||||||
WBPaper00028988 | |||||||
WBPaper00031488 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 08 Aug 2008 00:00:00 | ||||||
Automated_description | Enables RNA binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of cytoplasmic mRNA processing body assembly; neuron differentiation; and regulation of gene expression. Located in nuclear speck. Expressed widely. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C50E10.4a | |||||
C50E10.4b | |||||||
C50E10.4c | |||||||
Corresponding_CDS_history | C50E10.4:wp89 | ||||||
Corresponding_transcript | C50E10.4a.1 | ||||||
C50E10.4b.1 | |||||||
C50E10.4c.1 | |||||||
Associated_feature | WBsf981311 | ||||||
WBsf990051 | |||||||
WBsf990052 | |||||||
WBsf990053 | |||||||
WBsf1013409 | |||||||
WBsf1013410 | |||||||
WBsf1013411 | |||||||
WBsf222260 | |||||||
WBsf222261 | |||||||
Transcription_factor | WBTranscriptionFactor000203 | ||||||
Experimental_info | RNAi_result (21) | ||||||
Expr_pattern | Expr2597 | ||||||
Expr12241 | |||||||
Expr1025868 | |||||||
Expr1032460 | |||||||
Expr1146873 | |||||||
Expr2016005 | |||||||
Expr2034240 | |||||||
Drives_construct | WBCnstr00000173 | ||||||
WBCnstr00000174 | |||||||
WBCnstr00035311 | |||||||
Construct_product | WBCnstr00035311 | ||||||
Microarray_results (29) | |||||||
Expression_cluster (128) | |||||||
Interaction (55) | |||||||
Map_info | Map | II | Position | 8.55189 | Error | 0.18042 | |
Positive | Positive_clone | C50E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4624 | |||||
4686 | |||||||
Pseudo_map_position | |||||||
Reference (28) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |