cbd-1 encodes a large (1319-residue) protein with 12 chitin-binding peritrophin-A domains; cbd-1(RNAi) animals have an osmotically-sensitive embryonic lethal phenotype due to defects in eggshell synthesis; CBD-1's multiple peritrophin-A domains might enable mechanical cross-linking of chitin; the N-terminal region of CBD-1 forms a complex with PERM-2 and PERM-4 to promote structural integrity of the outer vitelline layer of the eggshell; other regions of CBD-1 interact with EGG-1/2 and CHS-1 to promote assembly of a functionally distinct complex involved in fertilization and the oocyte-to-embryo transition.
Predicted to enable chitin binding activity. Involved in eggshell formation; positive regulation of protein localization to cell cortex; and positive regulation of protein localization to plasma membrane. Located in cell periphery. Expressed in germ line and oocyte.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.