WormBase Tree Display for Gene: WBGene00010272

WBGene00010272 SMap: S_parent: Sequence: F58G6
  Identity: Version: 2
    Name: CGC_name: amph-1 Person_evidence: WBPerson217
      Sequence_name: F58G6.1
      Molecular_name: F58G6.1
        F58G6.1.1
        CE03428
        F58G6.1.2
      Other_name: CELE_F58G6.1 Accession_evidence: NDB BX284604
      Public_name: amph-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 02 Feb 2007 10:20:45 WBPerson2970 Name_change: CGC_name: amph-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: amph
    Allele (61)
    Strain: WBStrain00033163
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (43)
    Structured_description: Automated_description: Predicted to enable phospholipid binding activity. Involved in lipid tube assembly involved in organelle fission; nucleus localization; and nucleus organization. Located in nuclear envelope; perinuclear region of cytoplasm; and recycling endosome. Expressed in several structures, including coelomocyte; gonadal sheath cell; hypodermis; intestinal cell; and pharynx. Human ortholog(s) of this gene implicated in breast carcinoma; centronuclear myopathy 2; and prostate adenocarcinoma. Is an ortholog of human BIN1 (bridging integrator 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111220 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1052)
      DOID:3459 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1052)
      DOID:2526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1052)
  Molecular_info: Corresponding_CDS: F58G6.1
    Corresponding_transcript: F58G6.1.1
      F58G6.1.2
    Other_sequence (36)
    Associated_feature: WBsf652075
      WBsf652076
      WBsf997456
      WBsf1017985
      WBsf230598
      WBsf230599
  Experimental_info: RNAi_result: WBRNAi00106485 Inferred_automatically: RNAi_primary
      WBRNAi00016018 Inferred_automatically: RNAi_primary
      WBRNAi00114392 Inferred_automatically: RNAi_primary
      WBRNAi00098502 Inferred_automatically: RNAi_primary
      WBRNAi00065623 Inferred_automatically: RNAi_primary
      WBRNAi00033134 Inferred_automatically: RNAi_primary
      WBRNAi00049056 Inferred_automatically: RNAi_primary
      WBRNAi00084418 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr6257
      Expr8854
      Expr8855
      Expr12540
      Expr1018776
      Expr1034481
      Expr1152797
      Expr2009324
      Expr2027560
    Drives_construct: WBCnstr00002089
      WBCnstr00013564
      WBCnstr00031539
    Construct_product: WBCnstr00005951
      WBCnstr00013564
      WBCnstr00021614
      WBCnstr00031539
    Antibody: WBAntibody00002062
    Microarray_results (24)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Oogenic
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051311:VGLN-1-interacting
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:clk-1(qm30)_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055969:electromagnetic-field_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:F49E2.5_8378-anc-1_2769
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064992:Eugenol_upregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00025032:cluster_25
      WBPaper00025032:cluster_39
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00030985:Serratia_marcesens_upregulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_I
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      [cgc5767]:cluster_4
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(122_min)
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SET
      [cgc5767]:expression_class_SE_pi(83_min)
    Interaction (78)
  Map_info: Map: IV Position: 4.34538 Error: 0.000519
    Positive: Positive_clone: F58G6 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00035466
    WBPaper00036494
    WBPaper00038491
    WBPaper00042727
    WBPaper00048576
    WBPaper00048715
    WBPaper00051840
    WBPaper00055090
    WBPaper00061063
    WBPaper00064699
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene