| WBGene00009004 | SMap | S_parent | Sequence | F21C3 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | pfd-6 | Person_evidence | WBPerson3663 |
| | | | | | WBPerson2136 |
| | | Sequence_name | F21C3.5 |
| | | Molecular_name | F21C3.5 |
| | | | F21C3.5.1 |
| | | | CE05680 |
| | | Other_name | CELE_F21C3.5 | Accession_evidence | NDB | BX284601 |
| | | Public_name | pfd-6 |
| | DB_info | Database | AceView | gene | 1H860 |
| | | | WormQTL | gene | WBGene00009004 |
| | | | WormFlux | gene | WBGene00009004 |
| | | | NDB | locus_tag | CELE_F21C3.5 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00009004|UniProtKB=P52554 |
| | | | | family | PTHR21431 |
| | | | NCBI | gene | 172474 |
| | | | RefSeq | protein | NM_059657.6 |
| | | | SwissProt | UniProtAcc | P52554 |
| | | | TREEFAM | TREEFAM_ID | TF315166 |
| | | | UniProt_GCRP | UniProtAcc | P52554 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 02 Aug 2006 11:39:27 | WBPerson2970 | Name_change | CGC_name | pfd-6 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | pfd |
| | Allele (15) |
| | Strain | WBStrain00027642 |
| | | WBStrain00037185 |
| | | WBStrain00037512 |
| | RNASeq_FPKM (74) |
| | GO_annotation (11) |
| | Contained_in_operon | CEOP1384 |
| | Ortholog (35) |
| | Structured_description | Concise_description | pfd-6 encodes a putative prefoldin 6 subunit, orthologous to human PFDN6 (OMIM:605660), required for normal microtubule growth and distal tip cell migration; PFD-6 is expressed cytoplasmically in most, if not all, tissues, including the germline; in mass RNAi assays, PFD-6 is required for normal mitotic spindle position, embryonic and larval viability, fertility, body shape, vulval development, and locomotion, and for normally rapid growth; pfd-6(RNAi) embryos show a reduced microtubule growth rate. | Paper_evidence | WBPaper00004402 |
| | | | | | WBPaper00006395 |
| | | | | | WBPaper00025054 |
| | | | | | WBPaper00028783 |
| | | | | | WBPaper00031309 |
| | | | | | WBPaper00031362 |
| | | | | | WBPaper00031363 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 14 Jan 2008 00:00:00 |
| | | Automated_description | Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and protein folding. Located in cytoplasm. Expressed in body wall musculature; hypodermal cell; intestinal cell; and non-striated muscle. Is an ortholog of human PFDN6 (prefoldin subunit 6). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F21C3.5 |
| | Corresponding_transcript | F21C3.5.1 |
| | Other_sequence (31) |
| | Associated_feature | WBsf649304 |
| | | WBsf664429 |
| | | WBsf219731 |
| | | WBsf219732 |
| Experimental_info | RNAi_result (11) |
| | Expr_pattern | Expr7841 |
| | | Expr14586 |
| | | Expr1020376 |
| | | Expr1033920 |
| | | Expr1149123 |
| | | Expr2014846 |
| | | Expr2033081 |
| | Drives_construct | WBCnstr00001361 |
| | | WBCnstr00032533 |
| | | WBCnstr00041173 |
| | Construct_product | WBCnstr00032533 |
| | | WBCnstr00041173 |
| | Regulate_expr_cluster | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055827:pfd-6(gk493446)_upregulated |
| | Antibody | WBAntibody00001342 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:isp-1-1(qm150)_upregulated |
| | | WBPaper00033070:Elbe_downregulated |
| | | WBPaper00035211:age-1_vs_age-1_downregulated |
| | | WBPaper00035211:age-1_vs_N2_downregulated |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_downregulated |
| | | WBPaper00038118:stress_downregulated_N2 |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(gk119)_upregulated |
| | | WBPaper00045316:prg-1_downregulated_L2 |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00048971:daf-16(mgDf50)_downregulated_L1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_6 |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00049920:hyl-2(tm2031)_downregulated |
| | | WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050225:flp-6(RNAi)_downregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:downregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053388:dauer_regulated_Cluster6 |
| | | WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00054493:hpl-2(tm1489)_downregulated |
| | | WBPaper00055049:S.gordonii_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00055827:pfd-6(gk493446)_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_downregulated_N2 |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00057288:Cold_downregulated_protein |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058691:WDR-5.1_interacting_protein |
| | | WBPaper00059254:PRG-1_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_protein |
| | | WBPaper00060100:SiNP_downregulated_mRNA |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:Y39B6A.3-pfd-6 |
| | | WBPaper00061651:CAN_enriched |
| | | WBPaper00061651:Germline_enriched |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064156:lbp-3(overexpress)_downregulated |
| | | WBPaper00064315:mes-4(bn73)_downregulated_EGCs |
| | | WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066038:mip-1(how5)_downregulated |
| | | WBPaper00066085:hda-3(ok1991)_downregulated |
| | | WBPaper00066085:sin-3(syb2172)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_2 |
| | | WBPaper00025032:cluster_38 |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00027342:alpha-Synuclein(WT)_upregulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00038231:Cry5B_1.5-fold_downregulated |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00053236:daf-16(mgDF50)_regulated_Starved |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_50 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(41_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_MD |
| | | [cgc5767]:expression_class_MD_pd(53_min) |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (152) |
| Map_info | Map | I | Position | 1.87364 | Error | 0.000337 |
| | Positive | Positive_clone | F21C3 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00031309 |
| | WBPaper00038491 |
| | WBPaper00051688 |
| | WBPaper00055090 |
| | WBPaper00055827 |
| | WBPaper00057394 |
| | WBPaper00064339 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
