WormBase Tree Display for Gene: WBGene00008546
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| WBGene00008546 | SMap | S_parent | Sequence | F07A11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gfat-1 | Paper_evidence | WBPaper00045007 | |||||
| Person_evidence | WBPerson759 | ||||||||
| Sequence_name | F07A11.2 | ||||||||
| Molecular_name | F07A11.2a | ||||||||
| F07A11.2a.1 | |||||||||
| CE03144 | |||||||||
| F07A11.2b | |||||||||
| CE27915 | |||||||||
| F07A11.2a.2 | |||||||||
| F07A11.2b.1 | |||||||||
| Other_name | CELE_F07A11.2 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | gfat-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 28 Apr 2014 09:19:20 | WBPerson2970 | Name_change | CGC_name | gfat-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gfat | ||||||||
| Allele (46) | |||||||||
| Strain | WBStrain00003539 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Contained_in_operon | CEOP2718 | ||||||||
| Ortholog (45) | |||||||||
| Paralog | WBGene00009035 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | gfat-1 encodes two isoforms of glucosamine--fructose-6-phosphate aminotransferase (EC:2.6.1.16, also known as glutamine-fructose-6-phosphate transaminase), paralogous to GFAT-2; GFAT-1 is predicted to catalyze the first, and rate-limiting, step of the hexosamine pathway in which glucosamine-6-phosphate is synthesized from L-glutamine and fructose-6-phosphate and ultimately converted to UDP-N-acetylglucosamine (UDP-GlcNAc); gfat-1 gain-of-function mutations result in resistance to endoplasmic reticulum stress and increased longevity as a result of increased UDP-Hex-NAc levels accompanied by increased activity of protein quality control mechanisms such as ER-associated protein degradation (ERAD), proteasomal activity, and autophagy; gfat-1 is expressed in many larval and adult tissues, most prominently in epidermal seam cells and the pharynx, and gfat-1 transcripts are somewhat enriched during oogenesis; gfat-1(RNAi) animals have an osmotically-sensitive embryonic lethal phenotype, presumably because of defects in chitin and eggshell synthesis. | Paper_evidence | WBPaper00006390 | |||||
| WBPaper00006525 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00028588 | |||||||||
| WBPaper00045007 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 09 May 2014 00:00:00 | ||||||||
| Automated_description | Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Involved in IRE1-mediated unfolded protein response. Expressed in tail. Used to study Machado-Joseph disease. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12; obesity; and type 2 diabetes mellitus. Is an ortholog of human GFPT1 (glutamine--fructose-6-phosphate transaminase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1440 | Homo sapiens | Paper_evidence | WBPaper00059351 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 03 Jun 2021 00:00:00 | ||||||||
| Potential_model | DOID:0110660 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4241) | |||||
| DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4241) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4241,HGNC:4242) | ||||||
| Models_disease_asserted | WBDOannot00000921 | ||||||||
| Molecular_info | Corresponding_CDS | F07A11.2a | |||||||
| F07A11.2b | |||||||||
| Corresponding_transcript | F07A11.2a.1 | ||||||||
| F07A11.2a.2 | |||||||||
| F07A11.2b.1 | |||||||||
| Other_sequence (92) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00025011 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00085584 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00008604 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094861 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00043841 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030589 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022653 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00008075 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram1061 | ||||||||
| Expr5667 | |||||||||
| Expr11670 | |||||||||
| Expr1019553 | |||||||||
| Expr1033724 | |||||||||
| Expr1147818 | |||||||||
| Expr2012025 | |||||||||
| Expr2030261 | |||||||||
| Drives_construct | WBCnstr00003993 | ||||||||
| WBCnstr00019261 | |||||||||
| WBCnstr00032882 | |||||||||
| Construct_product | WBCnstr00019261 | ||||||||
| WBCnstr00032882 | |||||||||
| Microarray_results (32) | |||||||||
| Expression_cluster (208) | |||||||||
| Interaction (148) | |||||||||
| Map_info | Map | II | Position | 3.78428 | |||||
| Positive | Positive_clone | F07A11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
